Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 November 2003:
Vol. 302. no. 5647, pp. 1049 - 1053
DOI: 10.1126/science.1082971
Prev | Table of Contents | Next

Reports

Enhanced Fitness Conferred by Naturally Occurring Variation in the Circadian Clock

Todd P. Michael,1 Patrice A. Salomé,1 Hannah J. Yu,1 Taylor R. Spencer,1 Emily L. Sharp,1 Mark A. McPeek,1 José M. Alonso,2* Joseph R. Ecker,2 C. Robertson McClung1{dagger}

Natural variation in clock parameters is necessary for the circadian clock to contribute to organismal fitness over a broad geographic range. Considerable variation is evident in the period, phase, and amplitude of 150 Arabidopsis accessions, and the period length is correlated with the day length at the latitude of origin, implying the adaptive significance of correctly regulated circadian timing. Quantitative trait loci analysis of recombinant inbred lines indicates that multiple loci interact to determine period, phase, and amplitude. The loss-of-function analysis of each member of the ARABIDOPSIS PSEUDO-RESPONSE REGULATOR family suggests that they are candidates for clock quantitative trait loci.

1 Dartmouth College, Department of Biological Sciences, Hanover, NH 03755, USA.
2 Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.


* Present address: Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695, USA.

{dagger} To whom correspondence should be addressed. E-mail: mcclung{at}dartmouth.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Circadian Timekeeping during Early Arabidopsis Development.
P. A. Salome, Q. Xie, and C. R. McClung (2008)
Plant Physiology 147, 1110-1125
   Abstract »    Full Text »    PDF »
Disruption of the Arabidopsis Circadian Clock Is Responsible for Extensive Variation in the Cold-Responsive Transcriptome.
Z. Bieniawska, C. Espinoza, A. Schlereth, R. Sulpice, D. K. Hincha, and M. A. Hannah (2008)
Plant Physiology 147, 263-279
   Abstract »    Full Text »    PDF »
Quantitative Trait Loci for the Circadian Clock in Neurospora crassa.
T.-S. Kim, B. A. Logsdon, S. Park, J. G. Mezey, and K. Lee (2007)
Genetics 177, 2335-2347
   Abstract »    Full Text »    PDF »
Distinct Light and Clock Modulation of Cytosolic Free Ca2+ Oscillations and Rhythmic CHLOROPHYLL A/B BINDING PROTEIN2 Promoter Activity in Arabidopsis.
X. Xu, C. T. Hotta, A. N. Dodd, J. Love, R. Sharrock, Y. W. Lee, Q. Xie, C. H. Johnson, and A. A.R. Webb (2007)
PLANT CELL 19, 3474-3490
   Abstract »    Full Text »    PDF »
Differential Expression of Genes Important for Adaptation in Capsella bursa-pastoris (Brassicaceae).
T. Slotte, K. Holm, L. M. McIntyre, U. Lagercrantz, and M. Lascoux (2007)
Plant Physiology 145, 160-173
   Abstract »    Full Text »    PDF »
Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana.
T. Kiba, R. Henriques, H. Sakakibara, and N.-H. Chua (2007)
PLANT CELL 19, 2516-2530
   Abstract »    Full Text »    PDF »
Genetic Linkages Between Circadian Clock-Associated Components and Phytochrome-Dependent Red Light Signal Transduction in Arabidopsis thaliana.
S. Ito, N. Nakamichi, Y. Nakamura, Y. Niwa, T. Kato, M. Murakami, M. Kita, T. Mizoguchi, K. Niinuma, T. Yamashino, et al. (2007)
Plant Cell Physiol. 48, 971-983
   Abstract »    Full Text »    PDF »
A Functional Link between Rhythmic Changes in Chromatin Structure and the Arabidopsis Biological Clock.
M. Perales and P. Mas (2007)
PLANT CELL 19, 2111-2123
   Abstract »    Full Text »    PDF »
TIME FOR COFFEE Encodes a Nuclear Regulator in the Arabidopsis thaliana Circadian Clock.
Z. Ding, A. J. Millar, A. M. Davis, and S. J. Davis (2007)
PLANT CELL 19, 1522-1536
   Abstract »    Full Text »    PDF »
Control of flowering time in temperate cereals: genes, domestication, and sustainable productivity.
J. Cockram, H. Jones, F. J. Leigh, D. O'Sullivan, W. Powell, D. A. Laurie, and A. J. Greenland (2007)
J. Exp. Bot.
   Abstract »    Full Text »    PDF »
Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci.
J. J. B. Keurentjes, J. Fu, I. R. Terpstra, J. M. Garcia, G. van den Ackerveken, L. B. Snoek, A. J. M. Peeters, D. Vreugdenhil, M. Koornneef, and R. C. Jansen (2007)
PNAS 104, 1708-1713
   Abstract »    Full Text »    PDF »
GIGANTEA Acts in Blue Light Signaling and Has Biochemically Separable Roles in Circadian Clock and Flowering Time Regulation.
E. L. Martin-Tryon, J. A. Kreps, and S. L. Harmer (2007)
Plant Physiology 143, 473-486
   Abstract »    Full Text »    PDF »
Natural Genetic Variation of Freezing Tolerance in Arabidopsis.
M. A. Hannah, D. Wiese, S. Freund, O. Fiehn, A. G. Heyer, and D. K. Hincha (2006)
Plant Physiology 142, 98-112
   Abstract »    Full Text »    PDF »
Conserved Expression Profiles of Circadian Clock-related Genes in Two Lemna Species Showing Long-day and Short-day Photoperiodic Flowering Responses.
K. Miwa, M. Serikawa, S. Suzuki, T. Kondo, and T. Oyama (2006)
Plant Cell Physiol. 47, 601-612
   Abstract »    Full Text »    PDF »
Plant circadian rhythms..
C. R. McClung (2006)
PLANT CELL 18, 792-803
   Full Text »    PDF »
Analysis of Phase of LUCIFERASE Expression Reveals Novel Circadian Quantitative Trait Loci in Arabidopsis.
C. Darrah, B. L. Taylor, K. D. Edwards, P. E. Brown, A. Hall, and H. G. McWatters (2006)
Plant Physiology 140, 1464-1474
   Abstract »    Full Text »    PDF »
FLOWERING LOCUS C Mediates Natural Variation in the High-Temperature Response of the Arabidopsis Circadian Clock.
K. D. Edwards, P. E. Anderson, A. Hall, N. S. Salathia, J. C.W. Locke, J. R. Lynn, M. Straume, J. Q. Smith, and A. J. Millar (2006)
PLANT CELL 18, 639-650
   Abstract »    Full Text »    PDF »
Evolution of a Length Polymorphism in the Human PER3 Gene, a Component of the Circadian System.
N. A. Nadkarni, M. E. Weale, M. von Schantz, and M. G. Thomas (2005)
J Biol Rhythms 20, 490-499
   Abstract »    PDF »
The Pseudo-Response Regulator Ppd-H1 Provides Adaptation to Photoperiod in Barley.
A. Turner, J. Beales, S. Faure, R. P. Dunford, and D. A. Laurie (2005)
Science 310, 1031-1034
   Abstract »    Full Text »    PDF »
Vernalization sensitivity in Arabidopsis thaliana (Brassicaceae): the effects of latitude and FLC variation.
J. R. Stinchcombe, A. L. Caicedo, R. Hopkins, C. Mays, E. W. Boyd, M. D. Purugganan, and J. Schmitt (2005)
Am. J. Botany 92, 1701-1707
   Abstract »    Full Text »    PDF »
Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage.
A. N. Dodd, N. Salathia, A. Hall, E. Kevei, R. Toth, F. Nagy, J. M. Hibberd, A. J. Millar, and A. A. R. Webb (2005)
Science 309, 630-633
   Abstract »    Full Text »    PDF »
Positive and Negative Factors Confer Phase-Specific Circadian Regulation of Transcription in Arabidopsis.
S. L. Harmer and S. A. Kay (2005)
PLANT CELL 17, 1926-1940
   Abstract »    Full Text »    PDF »
FRIGIDA-Independent Variation in Flowering Time of Natural Arabidopsis thaliana Accessions.
J. D. Werner, J. O. Borevitz, N. H. Uhlenhaut, J. R. Ecker, J. Chory, and D. Weigel (2005)
Genetics 170, 1197-1207
   Abstract »    Full Text »    PDF »
Natural Allelic Variation in the Temperature-Compensation Mechanisms of the Arabidopsis thaliana Circadian Clock.
K. D. Edwards, J. R. Lynn, P. Gyula, F. Nagy, and A. J. Millar (2005)
Genetics 170, 387-400
   Abstract »    Full Text »    PDF »
Pseudo-Response Regulators (PRRs) or True Oscillator Components (TOCs).
T. Mizuno and N. Nakamichi (2005)
Plant Cell Physiol. 46, 677-685
   Abstract »    Full Text »    PDF »
PSEUDO-RESPONSE REGULATORS, PRR9, PRR7 and PRR5, Together Play Essential Roles Close to the Circadian Clock of Arabidopsis thaliana.
N. Nakamichi, M. Kita, S. Ito, T. Yamashino, and T. Mizuno (2005)
Plant Cell Physiol. 46, 686-698
   Abstract »    Full Text »    PDF »
The Arabidopsis Pseudo-response Regulators, PRR5 and PRR7, Coordinately Play Essential Roles for Circadian Clock Function.
N. Nakamichi, M. Kita, S. Ito, E. Sato, T. Yamashino, and T. Mizuno (2005)
Plant Cell Physiol. 46, 609-619
   Abstract »    Full Text »    PDF »
PSEUDO-RESPONSE REGULATOR 7 and 9 Are Partially Redundant Genes Essential for the Temperature Responsiveness of the Arabidopsis Circadian Clock.
P. A. Salome and C. R. McClung (2005)
PLANT CELL 17, 791-803
   Abstract »    Full Text »    PDF »
New insights into plant development in New England.
L. Dolan and J. A. Langdale (2004)
Development 131, 5215-5220
   Abstract »    Full Text »    PDF »
The Arabidopsis thaliana Clock.
P. A. Salome and C. R. McClung (2004)
J Biol Rhythms 19, 425-435
   Abstract »    PDF »
Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.
M. Yasuhara, S. Mitsui, H. Hirano, R. Takanabe, Y. Tokioka, N. Ihara, A. Komatsu, M. Seki, K. Shinozaki, and T. Kiyosue (2004)
J. Exp. Bot. 55, 2015-2027
   Abstract »    Full Text »    PDF »
Circadian-Controlled Basic/Helix-Loop-Helix Factor, PIL6, Implicated in Light-Signal Transduction in Arabidopsis thaliana.
T. Fujimori, T. Yamashino, T. Kato, and T. Mizuno (2004)
Plant Cell Physiol. 45, 1078-1086
   Abstract »    Full Text »    PDF »
Characterization of Circadian-Associated APRR3 Pseudo-Response Regulator Belonging to the APRR1/TOC1 Quintet in Arabidopsis thaliana.
M. Murakami, T. Yamashino, and T. Mizuno (2004)
Plant Cell Physiol. 45, 645-650
   Abstract »    Full Text »    PDF »
Photoperiodism in Neurospora Crassa.
Y. Tan, M. Merrow, and T. Roenneberg (2004)
J Biol Rhythms 19, 135-143
   Abstract »    PDF »
CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis.
X. Daniel, S. Sugano, and E. M. Tobin (2004)
PNAS 101, 3292-3297
   Abstract »    Full Text »    PDF »
Input signals to the plant circadian clock.
A. J. Millar (2004)
J. Exp. Bot. 55, 277-283
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)