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Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders
Steven T. DeKosky1* and
Kenneth Marek2
Early detection of neurodegenerative disorders would provideclues to the underlying pathobiology of these diseases and wouldenable more effective diagnosis and treatment of patients. Recentadvances in molecular neuroscience have begun to provide thetools to detect diseases like Alzheimer's disease, Parkinson'sdisease, and others early in their course and potentially evenbefore the development of clinical manifestations of disease.These genetic, imaging, clinical, and biochemical tools arebeing validated in a number of studies. Early detection of theseslowly progressive diseases offers the promise of presymptomaticdiagnosis and, ultimately, of disease-modifying medicationsfor use early in disease and during the presymptomatic period.
1 Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 2 Institute for Neurodegenerative Disorders, New Haven, CT, USA.
* To whom correspondence should be addressed. E-mail: DeKoskyST{at}upmc.edu
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