Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 October 2003:
Vol. 302. no. 5645, pp. 605 - 608
DOI: 10.1126/science.1090585
Prev | Table of Contents | Next

Viewpoint

Molecular Imaging: Looking at Problems, Seeing Solutions

Harvey R. Herschman

Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With continued improvements in instrumentation, identification of better imaging targets by genome-based approaches, and design of better imaging probes by innovative chemistry, these technologies promise to play increasingly important roles in disease diagnosis and therapy.

Department of Biological Chemistry and Department of Molecular/Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, 341 Boyer Hall, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

E-mail: hherschman{at}mednet.ucla.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos (2008)
PNAS 105, 19126-19131
   Abstract »    Full Text »    PDF »
An Official ATS Conference Proceedings: Advances in Small-Animal Imaging Application to Lung Pathophysiology.
R. H. Brown, C. G. Irvin, G. B. Allen III, S. D. Shapiro, W. J. Martin, M. R. J. Kolb, D. M. Hyde, G. F. Nieman, D. D. Cody, M. Ishii, et al. (2008)
Proceedings of the ATS 5, 591-600
   Full Text »    PDF »
Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging.
S. B. Lee, M. Hassan, R. Fisher, O. Chertov, V. Chernomordik, G. Kramer-Marek, A. Gandjbakhche, and J. Capala (2008)
Clin. Cancer Res. 14, 3840-3849
   Abstract »    Full Text »    PDF »
Imaging of Gene Expression in Live Pancreatic Islet Cell Lines Using Dual-Isotope SPECT.
J. H. Tai, B. Nguyen, R. G. Wells, M. S. Kovacs, R. McGirr, F. S. Prato, T. G. Morgan, and S. Dhanvantari (2008)
J. Nucl. Med. 49, 94-102
   Abstract »    Full Text »    PDF »
Molecular Imaging of Cardiovascular Disease.
F. A. Jaffer, P. Libby, and R. Weissleder (2007)
Circulation 116, 1052-1061
   Full Text »    PDF »
The Carnegie Protein Trap Library: A Versatile Tool for Drosophila Developmental Studies.
M. Buszczak, S. Paterno, D. Lighthouse, J. Bachman, J. Planck, S. Owen, A. D. Skora, T. G. Nystul, B. Ohlstein, A. Allen, et al. (2007)
Genetics 175, 1505-1531
   Abstract »    Full Text »    PDF »
Modern Imaging Technologies in Toxicologic Pathology: An Overview.
X. Ying and T. M. Monticello (2006)
Toxicol Pathol 34, 815-826
   Abstract »    Full Text »    PDF »
Molecular imaging in cancer..
R. Weissleder (2006)
Science 312, 1168-1171
   Abstract »    Full Text »    PDF »
Molecular and Cellular Imaging of Atherosclerosis: Emerging Applications.
F. A. Jaffer, P. Libby, and R. Weissleder (2006)
J. Am. Coll. Cardiol. 47, 1328-1338
   Abstract »    Full Text »    PDF »
Monitoring the Antitumor Response of Naive and Memory CD8 T Cells in RAG1-/- Mice by Positron-Emission Tomography.
H. Su, D. S. Chang, S. S. Gambhir, and J. Braun (2006)
J. Immunol. 176, 4459-4467
   Abstract »    Full Text »    PDF »
Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter..
K. Hasegawa, L. Pham, M. K. O'Connor, M. J. Federspiel, S. J. Russell, and K.-W. Peng (2006)
Clin. Cancer Res. 12, 1868-1875
   Abstract »    Full Text »    PDF »
Report of a Summit on Molecular Imaging.
M. Thakur and B. C. Lentle (2006)
Am. J. Roentgenol. 186, 297-299
   Full Text »    PDF »
Screening phage display libraries for organ-specific vascular immunotargeting in vivo.
P. Valadon, J. D. Garnett, J. E. Testa, M. Bauerle, P. Oh, and J. E. Schnitzer (2006)
PNAS 103, 407-412
   Abstract »    Full Text »    PDF »
Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model.
R. Ilagan, L. J. Zhang, J. Pottratz, K. Le, S. Salas, M. Iyer, L. Wu, S. S. Gambhir, and M. Carey (2005)
Mol. Cancer Ther. 4, 1662-1669
   Abstract »    Full Text »    PDF »
Molecular imaging: novel tools in visualizing rheumatoid arthritis.
A. Wunder, R. H. Straub, S. Gay, J. Funk, and U. Muller-Ladner (2005)
Rheumatology 44, 1341-1349
   Abstract »    Full Text »    PDF »
Report of a Summit on Molecular Imaging.
M. Thakur and B. C. Lentle (2005)
Radiology 236, 753-755
   Full Text »    PDF »
From the Cover: Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-{beta}-D-arabinofuranosyl)-5-iodouracil.
C. Bettegowda, C. A. Foss, I. Cheong, Y. Wang, L. Diaz, N. Agrawal, J. Fox, J. Dick, L. H. Dang, S. Zhou, et al. (2005)
PNAS 102, 1145-1150
   Abstract »    Full Text »    PDF »
Systems Biology and New Technologies Enable Predictive and Preventative Medicine.
L. Hood, J. R. Heath, M. E. Phelps, and B. Lin (2004)
Science 306, 640-643
   Abstract »    Full Text »    PDF »
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov Jr., L. Josephson, and R. Weissleder (2004)
PNAS 101, 12294-12299
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)