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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Seiji Tadokoro,1Sanford J. Shattil,1Koji Eto,1Vera Tai,1Robert C. Liddington,2José M. de Pereda,2Mark H. Ginsberg,1*David A. Calderwood1
Control of integrin affinity for ligands (integrin activation)is essential for normal cell adhesion, migration, and assemblyof an extracellular matrix. Integrin activation is usually mediatedthrough the integrin ß subunit cytoplasmic tail andcan be regulated by many different biochemical signaling pathways.We report that specific binding of the cytoskeletal proteintalin to integrin ß subunit cytoplasmic tails leadsto the conformational rearrangements of integrin extracellulardomains that increase their affinity. Thus, regulated bindingof talin to integrin ß tails is a final common elementof cellular signaling cascades that control integrin activation.
1 Department of Cell Biology, The Scripps Research Institute, The Burnham Institute, La Jolla, CA 92037, USA. 2 Program in Cell Adhesion, The Burnham Institute, La Jolla, CA 92037, USA.
* To whom correspondence should be addressed. E-mail: ginsberg{at}scripps.edu
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