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Science 26 September 2003:
Vol. 301. no. 5641, pp. 1882 - 1884
DOI: 10.1126/science.1089389
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Reports

DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires

Hao Yan,1* Sung Ha Park,1,2 Gleb Finkelstein,2 John H. Reif,1 Thomas H. LaBean1*

A DNA nanostructure consisting of four four-arm junctions oriented with a square aspect ratio was designed and constructed. Programmable self-assembly of 4 x 4 tiles resulted in two distinct lattice morphologies: uniform-width nanoribbons and two-dimensional nanogrids, which both display periodic square cavities. Periodic protein arrays were achieved by templated self-assembly of streptavidin onto the DNA nanogrids containing biotinylated oligonucleotides. On the basis of a two-step metallization procedure, the 4 x 4 nanoribbons acted as an excellent scaffold for the production of highly conductive, uniform-width, silver nanowires.

1 Department of Computer Science, Duke University, Durham, NC 27708, USA.
2 Department of Physics, Duke University, Durham, NC 27708, USA.

* To whom correspondence should be addressed. E-mail: thl{at}cs.duke.edu (T.H.L); hy1{at}cs.duke.edu (H.Y.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)