Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 September 2003:
Vol. 301. no. 5640, pp. 1731 - 1733
DOI: 10.1126/science.1086016
Prev | Table of Contents | Next

Reports

Demography of Dietary Restriction and Death in Drosophila

William Mair,1 Patrick Goymer,1,2 Scott D. Pletcher,1* Linda Partridge1{dagger}

Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.

1 Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
2 Natural Environment Research Council (NERC) Centre for Population Biology, Imperial College, London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK.


* Present address: Department of Molecular and Human Genetics and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

{dagger} To whom correspondence should be addressed. E-mail: l.partridge{at}ucl.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Motif module map reveals enforcement of aging by continual NF-{kappa}B activity.
A. S. Adler, S. Sinha, T. L.A. Kawahara, J. Y. Zhang, E. Segal, and H. Y. Chang (2007)
Genes & Dev. 21, 3244-3257
   Abstract »    Full Text »    PDF »
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals.
A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer (2007)
Physiol Rev 87, 1175-1213
   Abstract »    Full Text »    PDF »
Adult-Limited Dietary Restriction Slows Gompertzian Aging in Caenorhabditis elegans.
I. LENAERTS, S. V. EYGEN, and J. V. FLETEREN (2007)
Ann. N.Y. Acad. Sci. 1100, 442-448
   Abstract »    Full Text »    PDF »
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors.
S. Libert, J. Zwiener, X. Chu, W. VanVoorhies, G. Roman, and S. D. Pletcher (2007)
Science 315, 1133-1137
   Abstract »    Full Text »    PDF »
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
C. Selman, N. D. Kerrison, A. Cooray, M. D. W. Piper, S. J. Lingard, R. H. Barton, E. F. Schuster, E. Blanc, D. Gems, J. K. Nicholson, et al. (2006)
Physiol Genomics 27, 187-200
   Abstract »    Full Text »    PDF »
Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span.
B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, et al. (2006)
Science 314, 825-828
   Abstract »    Full Text »    PDF »
Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane Fatty Acid composition..
S. C. Faulks, N. Turner, P. L. Else, and A. J. Hulbert (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 781-794
   Abstract »    Full Text »    PDF »
Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction..
J. M. Dhahbi, T. Tsuchiya, H.-J. Kim, P. L. Mote, and S. R. Spindler (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 218-231
   Abstract »    Full Text »    PDF »
Flight activity, mortality rates, and lipoxidative damage in Drosophila..
T. Magwere, R. Pamplona, S. Miwa, P. Martinez-Diaz, M. Portero-Otin, M. D. Brand, and L. Partridge (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 136-145
   Abstract »    Full Text »    PDF »
Caloric Restriction and Aging: Controversial Issues.
E. J. Masoro (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 14-19
   Abstract »    Full Text »    PDF »
Aging as a Mitochondria-Mediated Atavistic Program: Can Aging Be Switched Off?.
V. P. SKULACHEV and V. D. LONGO (2005)
Ann. N.Y. Acad. Sci. 1057, 145-164
   Abstract »    Full Text »    PDF »
The Myth and Reality of Reversal of Aging by Hormesis.
J. S. SONNEBORN (2005)
Ann. N.Y. Acad. Sci. 1057, 165-176
   Abstract »    Full Text »    PDF »
Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction.
M. D. W. Piper, W. Mair, and L. Partridge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 549-555
   Abstract »    Full Text »    PDF »
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
S. J. Broughton, M. D. W. Piper, T. Ikeya, T. M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D. J. Withers, S. J. Leevers, et al. (2005)
PNAS 102, 3105-3110
   Abstract »    Full Text »    PDF »
Advances in measuring lifespan in the yeast Saccharomyces cerevisiae.
N. Minois, M. Frajnt, C. Wilson, and J. W. Vaupel (2005)
PNAS 102, 402-406
   Abstract »    Full Text »    PDF »
Aging-Related Research in the "-omics" Age.
M. Kaeberlein (2004)
Sci. Aging Knowl. Environ. 2004, pe39
   Abstract »    Full Text »
The Future of Aging Interventions: The Human Life Span Is Not That Limited: The Effect of Multiple Longevity Phenotypes.
R. Arking, V. Novoseltsev, and J. Novoseltseva (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B697-B704
   Abstract »    Full Text »    PDF »
Temporal linkage between the phenotypic and genomic responses to caloric restriction.
J. M. Dhahbi, H.-J. Kim, P. L. Mote, R. J. Beaver, and S. R. Spindler (2004)
PNAS 101, 5524-5529
   Abstract »    Full Text »    PDF »
Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster.
T. Magwere, T. Chapman, and L. Partridge (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B3-9
   Abstract »    Full Text »    PDF »
The control of growth.
H. F. Nijhout (2003)
Development 130, 5863-5867
   Abstract »    Full Text »    PDF »
Linking Development and Aging.
B. J. Zwaan (2003)
Sci. Aging Knowl. Environ. 2003, pe32-32
   Abstract »    Full Text »
Second Chance.
M. Beckman (2003)
Sci. Aging Knowl. Environ. 2003, nw133-133
   Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)