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Science 22 August 2003:
Vol. 301. no. 5636, pp. 1102 - 1104
DOI: 10.1126/science.1086881
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Reports

Stability of Retrieved Memory: Inverse Correlation with Trace Dominance

Mark Eisenberg, Tali Kobilo, Diego E. Berman,* Yadin Dudai{dagger}

In memory consolidation, the memory trace stabilizes and becomes resistant to certain amnesic agents. The textbook account is that for any memorized item, consolidation starts and ends just once. However, evidence has accumulated that upon activation in retrieval, the trace may reconsolidate. Whereas some authors reported transient renewed susceptibility of retrieved memories to consolidation blockers, others could not detect it. Here, we report that in both conditioned taste aversion in the rat and fear conditioning in the medaka fish, the stability of retrieved memory is inversely correlated with the control of behavior by that memory. This result may explain some conflicting findings on reconsolidation of activated memories.

Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.



* Present address: Center for Neurobiology & Behavior, Columbia University, New York, NY 10032, USA.

{dagger} To whom correspondence should be addressed. E-mail: yadin.dudai{at}weizmann.ac.il

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Science. ISSN 0036-8075 (print), 1095-9203 (online)