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Science 13 June 2003:
Vol. 300. no. 5626, pp. 1742 - 1745
DOI: 10.1126/science.1085881
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Reports

Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome

José M. Ranz, Cristian I. Castillo-Davis, Colin D. Meiklejohn, Daniel L. Hartl*

Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ~83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

* To whom correspondence should be addressed. E-mail: dhartl{at}oeb.harvard.edu

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