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Science 6 June 2003:
Vol. 300. no. 5625, pp. 1574 - 1577
DOI: 10.1126/science.1079817
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Reports

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Keyong Du,1* Stephan Herzig,1* Rohit N. Kulkarni,2 Marc Montminy1{dagger}

Insulin resistance is a major hallmark in the development of type II diabetes, which is characterized by the failure of insulin to promote glucose uptake in muscle and to suppress glucose production in liver. The serine-threonine kinase Akt (PKB) is a principal target of insulin signaling that inhibits hepatic glucose output when glucose is available from food. Here we show that TRB3, a mammalian homolog of Drosophila tribbles, functions as a negative modulator of Akt. TRB3 expression is induced in liver under fasting conditions, and TRB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase. Amounts of TRB3 RNA and protein were increased in livers of db/db diabetic mice compared with those in wild-type mice. Hepatic overexpression of TRB3 in amounts comparable to those in db/db mice promoted hyperglycemia and glucose intolerance. Our results suggest that, by interfering with Akt activation, TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes.

1 Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037—1002, USA.
2 Joslin Diabetes Center, Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.



* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: montminy{at}salk.edu

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   Abstract »    Full Text »    PDF »
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