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Science 6 June 2003:
Vol. 300. no. 5625, pp. 1569 - 1574
DOI: 10.1126/science.1084671
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Reports

Equatorial Retention of the Contractile Actin Ring by Microtubules During Cytokinesis

Mercedes Pardo* and Paul Nurse

In most eukaryotes cytokinesis is brought about by a contractile actin ring located at the division plane. Here, in fission yeast the actin ring was found to be required to generate late-mitotic microtubular structures located at the division plane, and these in turn maintained the medial position of the actin ring. When these microtubular structures were disrupted, the actin ring migrated away from the cell middle in a membrane traffic–dependent manner, resulting in asymmetrical cell divisions that led to genomic instability. We propose that these microtubular structures contribute to a checkpoint control that retains the equatorial position of the ring when progression through cytokinesis is delayed.

Cell Cycle Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

* To whom correspondence should be addressed. E-mail: mercedes.pardo{at}cancer.org.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)