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Science 6 June 2003:
Vol. 300. no. 5625, pp. 1529 - 1530
DOI: 10.1126/science.1085259
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Wnt Signaling, Ca2+, and Cyclic GMP: Visualizing Frizzled Functions

Hsien-yu Wang1 and Craig C. Malbon2*

Wnts control the specification of cell fate, cell adhesion, migration, polarity, and proliferation. Their roles in development have been probed in fruit flies, nematodes, zebrafish, frogs, and mice. Some Wnts inhibit the degradation of ß-catenin, which can regulate transcription of specific genes. Other Wnts exert their influences in other ways, such as increasing intracellular concentrations of Ca2+ and decreasing intracellular concentrations of cyclic guanosine monophosphate (cGMP). Heterotrimeric guanine nucleotide–binding proteins (G proteins) and RGS proteins have been implicated in Wnt signaling. Wnt regulation of intracellular Ca2+ and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway.

1 Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794–8661, USA.
2 Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794–8651, USA.

* To whom correspondence should be addressed. E-mail: craig{at}pharm.sunysb.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)