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Interleukin-4 and Interleukin-13 Signaling Connections Maps
Ann E. Kelly-Welch,1Erica M. Hanson,1Mark R. Boothby,2Achsah D. Keegan1*
Cytokines are inflammatory mediators important in respondingto pathogens and other foreign challenges. Interleukin-4 (IL-4)and IL-13 are two cytokines produced by T helper type 2 cells,mast cells, and basophils. In addition to their physiologicalroles, these cytokines are also implicated in pathological conditionssuch as asthma and allergy. IL-4 can stimulate two receptors,type I and type II, whereas IL-13 signaling is mediated onlyby the type II receptor (see the STKE Connections Maps). Thesecytokines activate the Janus kinase/signal transducer and activatorof transcription (JAK/STAT) signaling cascades, which may contributeto allergic responses. In addition, stimulation of the phosphatidylinositol3-kinase (PI3K) pathway through recruitment of members of theinsulin receptor substrate family may contribute to survivaland proliferation.
1 Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, and the Institute for Biomedical Sciences, George Washington Medical Center, Washington, DC 20037, USA. 2 Department of Microbiology, Vanderbilt University, Nashville, TN 37232, USA.
* To whom correspondence should be addressed. E-mail: keegana{at}usa.redcross.org
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DATABASE OF CELL SIGNALING
Interleukin 13 (IL-13) Pathway
Ann E. Kelly-Welch, Erica M. Hanson and Achsah D. Keegan Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7786 |Canonical Pathway »
DATABASE OF CELL SIGNALING
Interleukin 4 (IL-4) Pathway
Ann E. Kelly-Welch, Erica M. Hanson and Achsah D. Keegan Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7740 |Canonical Pathway »
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