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Science 30 May 2003: Vol. 300. no. 5624, pp. 1439 - 1443 DOI: 10.1126/science.1083516
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Reports
Characterization of Mammalian Selenoproteomes
Gregory V. Kryukov,1
Sergi Castellano,2
Sergey V. Novoselov,1
Alexey V. Lobanov,1
Omid Zehtab,1
Roderic Guigó,2
Vadim N. Gladyshev1*
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.
1 Department of Biochemistry, University of Nebraska, Lincoln, NE 685880664, USA.
2 Grup de Recerca en Informàtica Biomèdica, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain.
* To whom correspondence should be addressed. E-mail: vgladyshev1{at}unl.edu
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| Abstract »
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| Full Text »
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| PDF »
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| Abstract »
| Full Text »
| PDF »
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Ann. N.Y. Acad. Sci.
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- M. Bauer-Marinovic, S. Florian, K. Muller-Schmehl, H. Glatt, and G. Jacobasch (2006)
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- A. A. Sayed, S. K. Cook, and D. L. Williams (2006)
J. Biol. Chem.
281, 17001-17010
| Abstract »
| Full Text »
| PDF »
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- V. Diwadkar-Navsariwala, G. S. Prins, S. M. Swanson, L. A. Birch, V. H. Ray, S. Hedayat, D. L. Lantvit, and A. M. Diamond (2006)
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103, 8179-8184
| Abstract »
| Full Text »
| PDF »
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- M.-H. Yoo, X.-M. Xu, B. A. Carlson, V. N. Gladyshev, and D. L. Hatfield (2006)
J. Biol. Chem.
281, 13005-13008
| Abstract »
| Full Text »
| PDF »
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- R. Irons, B. A. Carlson, D. L. Hatfield, and C. D. Davis (2006)
J. Nutr.
136, 1311-1317
| Abstract »
| Full Text »
| PDF »
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- A. L. Sabichi, J. J. Lee, R. J. Taylor, I. M. Thompson, B. J. Miles, C. M. Tangen, L. M. Minasian, L. L. Pisters, J. R. Caton, J. W. Basler, et al. (2006)
Clin. Cancer Res.
12, 2178-2184
| Abstract »
| Full Text »
| PDF »
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- L. Schomburg, C. Riese, M. Michaelis, E. Griebert, M. O. Klein, R. Sapin, U. Schweizer, and J. Kohrle (2006)
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147, 1306-1313
| Abstract »
| Full Text »
| PDF »
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- A. D. Ferguson, V. M. Labunskyy, D. E. Fomenko, D. Arac, Y. Chelliah, C. A. Amezcua, J. Rizo, V. N. Gladyshev, and J. Deisenhofer (2006)
J. Biol. Chem.
281, 3536-3543
| Abstract »
| Full Text »
| PDF »
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- A. V. Lobanov, C. Delgado, S. Rahlfs, S. V. Novoselov, G. V. Kryukov, S. Gromer, D. L. Hatfield, K. Becker, and V. N. Gladyshev (2006)
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34, 496-505
| Abstract »
| Full Text »
| PDF »
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- S. A. Shabalina, A. Y. Ogurtsov, and N. A. Spiridonov (2006)
Nucleic Acids Res.
34, 2428-2437
| Abstract »
| Full Text »
| PDF »
- Sequence-based heuristics for faster annotation of non-coding RNA families.
- Z. Weinberg and W. L. Ruzzo (2006)
Bioinformatics
22, 35-39
| Abstract »
| Full Text »
| PDF »
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- X.-M. Xu, H. Mix, B. A. Carlson, P. J. Grabowski, V. N. Gladyshev, M. J. Berry, and D. L. Hatfield (2005)
J. Biol. Chem.
280, 41568-41575
| Abstract »
| Full Text »
| PDF »
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- J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont (2005)
Endocr. Rev.
26, 944-984
| Abstract »
| Full Text »
| PDF »
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- P. H. M. Klaren, R. Haasdijk, J. R. Metz, L. M. C. Nitsch, V. M. Darras, S. Van der Geyten, and G. Flik (2005)
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| Abstract »
| Full Text »
| PDF »
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- A. N. Uddin, F. J. Burns, and T. G. Rossman (2005)
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| Abstract »
| Full Text »
| PDF »
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- Y. Hu, R. V. Benya, R. E. Carroll, and A. M. Diamond (2005)
J. Nutr.
135, 3021S-3024S
| Abstract »
| Full Text »
| PDF »
- A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase.
- V. M. Labunskyy, A. D. Ferguson, D. E. Fomenko, Y. Chelliah, D. L. Hatfield, and V. N. Gladyshev (2005)
J. Biol. Chem.
280, 37839-37845
| Abstract »
| Full Text »
| PDF »
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- S. Castellano, A. V. Lobanov, C. Chapple, S. V. Novoselov, M. Albrecht, D. Hua, A. Lescure, T. Lengauer, A. Krol, V. N. Gladyshev, et al. (2005)
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102, 16188-16193
| Abstract »
| Full Text »
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- N. T. Akbaraly, J. Arnaud, I. Hininger-Favier, V. Gourlet, A.-M. Roussel, and C. Berr (2005)
Clin. Chem.
51, 2117-2123
| Abstract »
| Full Text »
| PDF »
- Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
- B. N. Lilley and H. L. Ploegh (2005)
PNAS
102, 14296-14301
| Abstract »
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| PDF »
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- W. M. Valentine, K. E. Hill, L. M. Austin, H. L. Valentine, D. Goldowitz, and R. F. Burk (2005)
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| Abstract »
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| Abstract »
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- A. Banning, S. Deubel, D. Kluth, Z. Zhou, and R. Brigelius-Flohe (2005)
Mol. Cell. Biol.
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| Abstract »
| Full Text »
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- Y. Zhang and V. N. Gladyshev (2005)
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| Abstract »
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- Y. Zhang, P. V. Baranov, J. F. Atkins, and V. N. Gladyshev (2005)
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| Abstract »
| Full Text »
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- D. Su, Y. Li, and V. N. Gladyshev (2005)
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| PDF »
- Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?.
- K. Taskov, C. Chapple, G. V. Kryukov, S. Castellano, A. V. Lobanov, K. V. Korotkov, R. Guigo, and V. N. Gladyshev (2005)
Nucleic Acids Res.
33, 2227-2238
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- Effectiveness of selenium supplements in a low-selenium area of China.
- Y. Xia, K. E Hill, D. W Byrne, J. Xu, and R. F Burk (2005)
Am. J. Clinical Nutrition
81, 829-834
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- Epithelium-Specific Glutathione Peroxidase, Gpx2, Is Involved in the Prevention of Intestinal Inflammation in Selenium-Deficient Mice.
- R. S. Esworthy, L. Yang, P. H. Frankel, and F.-F. Chu (2005)
J. Nutr.
135, 740-745
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- Expression of Gastrointestinal Glutathione Peroxidase Is Inversely Correlated to the Presence of Hepatitis C Virus Subgenomic RNA in Human Liver Cells.
- M. Morbitzer and T. Herget (2005)
J. Biol. Chem.
280, 8831-8841
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- Selenium and endocrine systems.
- G. J Beckett and J. R Arthur (2005)
J. Endocrinol.
184, 455-465
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- Selenoproteins and the Metabolic Features of the Archaeal Ancestor of Eukaryotes.
- C. B. Foster (2005)
Mol. Biol. Evol.
22, 383-386
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- Selective Rescue of Selenoprotein Expression in Mice Lacking a Highly Specialized Methyl Group in Selenocysteine tRNA.
- B. A. Carlson, X.-M. Xu, V. N. Gladyshev, and D. L. Hatfield (2005)
J. Biol. Chem.
280, 5542-5548
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- A selenocysteine tRNA and SECIS element in Plasmodium falciparum.
- T. MOURIER, A. PAIN, B. BARRELL, and S. GRIFFITHS-JONES (2005)
RNA
11, 119-122
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