Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 30 May 2003:
Vol. 300. no. 5624, pp. 1439 - 1443
DOI: 10.1126/science.1083516
Prev | Table of Contents

Reports

Characterization of Mammalian Selenoproteomes

Gregory V. Kryukov,1 Sergi Castellano,2 Sergey V. Novoselov,1 Alexey V. Lobanov,1 Omid Zehtab,1 Roderic Guigó,2 Vadim N. Gladyshev1*

In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.

1 Department of Biochemistry, University of Nebraska, Lincoln, NE 68588–0664, USA.
2 Grup de Recerca en Informàtica Biomèdica, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain.

* To whom correspondence should be addressed. E-mail: vgladyshev1{at}unl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Consequences of Genetic Variations in the Glutathione Peroxidase 1 Selenoenzyme.
P. Zhuo, M. Goldberg, L. Herman, B.-S. Lee, H. Wang, R. L. Brown, C. B. Foster, U. Peters, and A. M. Diamond (2009)
Cancer Res. 69, 8183-8190
   Abstract »    Full Text »    PDF »
Crystal structure of human selenocysteine tRNA.
Y. Itoh, S. Chiba, S.-i. Sekine, and S. Yokoyama (2009)
Nucleic Acids Res. 37, 6259-6268
   Abstract »    Full Text »    PDF »
Novel structural determinants in human SECIS elements modulate the translational recoding of UGA as selenocysteine.
L. Latreche, O. Jean-Jean, D. M. Driscoll, and L. Chavatte (2009)
Nucleic Acids Res. 37, 5868-5880
   Abstract »    Full Text »    PDF »
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
M. Schneider, H. Forster, A. Boersma, A. Seiler, H. Wehnes, F. Sinowatz, C. Neumuller, M. J. Deutsch, A. Walch, M. Hrabe de Angelis, et al. (2009)
FASEB J 23, 3233-3242
   Abstract »    Full Text »    PDF »
Low Exchangeability of Selenocysteine, the 21st Amino Acid, in Vertebrate Proteins.
S. Castellano, A. M. Andres, E. Bosch, M. Bayes, R. Guigo, and A. G. Clark (2009)
Mol. Biol. Evol. 26, 2031-2040
   Abstract »    Full Text »    PDF »
Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.
J. Lu, L. Zhong, M. E. Lonn, R. F. Burk, K. E. Hill, and A. Holmgren (2009)
FASEB J 23, 2394-2402
   Abstract »    Full Text »    PDF »
The Human SepSecS-tRNASec Complex Reveals the Mechanism of Selenocysteine Formation.
S. Palioura, R. L. Sherrer, T. A. Steitz, D. Soll, and M. Simonovic (2009)
Science 325, 321-325
   Abstract »    Full Text »    PDF »
Selenoprotein S/SEPS1 Modifies Endoplasmic Reticulum Stress in Z Variant {alpha}1-Antitrypsin Deficiency.
E. Kelly, C. M. Greene, T. P. Carroll, N. G. McElvaney, and S. J. O'Neill (2009)
J. Biol. Chem. 284, 16891-16897
   Abstract »    Full Text »    PDF »
Methods of assessment of selenium status in humans: a systematic review.
K. Ashton, L. Hooper, L. J Harvey, R. Hurst, A. Casgrain, and S. J Fairweather-Tait (2009)
Am. J. Clinical Nutrition 89, 2025S-2039S
   Abstract »    Full Text »    PDF »
Selenoprotein Gene Expression in Thyroid and Pituitary of Young Pigs Is Not Affected by Dietary Selenium Deficiency or Excess.
J.-C. Zhou, H. Zhao, J.-G. Li, X.-J. Xia, K.-N. Wang, Y.-J. Zhang, Y. Liu, Y. Zhao, and X. G. Lei (2009)
J. Nutr. 139, 1061-1066
   Abstract »    Full Text »    PDF »
Selenium Requirements Are Higher for Glutathione Peroxidase-1 mRNA than Gpx1 Activity in Rat Testis.
S. C. Schriever, K. M. Barnes, J. K. Evenson, A. M. Raines, and R. A. Sunde (2009)
Experimental Biology and Medicine 234, 513-521
   Abstract »    Full Text »    PDF »
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
E. Aeby, S. Palioura, M. Pusnik, J. Marazzi, A. Lieberman, E. Ullu, D. Soll, and A. Schneider (2009)
PNAS 106, 5088-5092
   Abstract »    Full Text »    PDF »
SECISaln, a web-based tool for the creation of structure-based alignments of eukaryotic SECIS elements.
C. E. Chapple, R. Guigo, and A. Krol (2009)
Bioinformatics 25, 674-675
   Abstract »    Full Text »    PDF »
Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1.
Q. Cheng, T. Sandalova, Y. Lindqvist, and E. S. J. Arner (2009)
J. Biol. Chem. 284, 3998-4008
   Abstract »    Full Text »    PDF »
The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) Reveals the Need for Better Understanding of Selenium Biology.
D. L. Hatfield and V. N. Gladyshev (2009)
Mol. Interv. 9, 18-21
   Abstract »    Full Text »    PDF »
Transcript Analysis of the Selenoproteome Indicates That Dietary Selenium Requirements of Rats Based on Selenium-Regulated Selenoprotein mRNA Levels Are Uniformly Less Than Those Based on Glutathione Peroxidase Activity.
K. M. Barnes, J. K. Evenson, A. M. Raines, and R. A. Sunde (2009)
J. Nutr. 139, 199-206
   Abstract »    Full Text »    PDF »
Selenoproteins.
J. Lu and A. Holmgren (2009)
J. Biol. Chem. 284, 723-727
   Abstract »    Full Text »    PDF »
Glutathione Peroxidase 3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor {gamma} in Human Skeletal Muscle Cells.
S. S. Chung, M. Kim, B.-S. Youn, N. S. Lee, J. W. Park, I. K. Lee, Y. S. Lee, J. B. Kim, Y. M. Cho, H. K. Lee, et al. (2009)
Mol. Cell. Biol. 29, 20-30
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Selenoprotein, Thioredoxin Reductase, in a Unicellular Marine Haptophyte Alga, Emiliania huxleyi.
H. Araie, I. Suzuki, and Y. Shiraiwa (2008)
J. Biol. Chem. 283, 35329-35336
   Abstract »    Full Text »    PDF »
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling.
B. Gereben, A. M. Zavacki, S. Ribich, B. W. Kim, S. A. Huang, W. S. Simonides, A. Zeold, and A. C. Bianco (2008)
Endocr. Rev. 29, 898-938
   Abstract »    Full Text »    PDF »
Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice.
A. Banning, A. Kipp, S. Schmitmeier, M. Lowinger, S. Florian, S. Krehl, S. Thalmann, R. Thierbach, P. Steinberg, and R. Brigelius-Flohe (2008)
Cancer Res. 68, 9746-9753
   Abstract »    Full Text »    PDF »
Functional characterization of alternatively spliced human SECISBP2 transcript variants.
L. V. Papp, J. Wang, D. Kennedy, D. Boucher, Y. Zhang, V. N. Gladyshev, R. N. Singh, and K. K. Khanna (2008)
Nucleic Acids Res. 36, 7192-7206
   Abstract »    Full Text »    PDF »
Radical-free biology of oxidative stress.
D. P. Jones (2008)
Am J Physiol Cell Physiol 295, C849-C868
   Abstract »    Full Text »    PDF »
Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes.
I. Ahrens, C. Ellwanger, B. K. Smith, N. Bassler, Y. C. Chen, I. Neudorfer, A. Ludwig, C. Bode, and K. Peter (2008)
J. Leukoc. Biol. 83, 1388-1395
   Abstract »    Full Text »    PDF »
Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.
L. Grumolato, H. Ghzili, M. Montero-Hadjadje, S. Gasman, J. Lesage, Y. Tanguy, L. Galas, D. Ait-Ali, J. Leprince, N. C. Guerineau, et al. (2008)
FASEB J 22, 1756-1768
   Abstract »    Full Text »    PDF »
Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma.
U. Peters, N. Chatterjee, R. B. Hayes, R. E. Schoen, Y. Wang, S. J. Chanock, and C. B. Foster (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 1144-1154
   Abstract »    Full Text »    PDF »
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
K. Sheppard, J. Yuan, M. J. Hohn, B. Jester, K. M. Devine, and D. Soll (2008)
Nucleic Acids Res. 36, 1813-1825
   Abstract »    Full Text »    PDF »
Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells.
G. E. Olson, V. P. Winfrey, K. E. Hill, and R. F. Burk (2008)
J. Biol. Chem. 283, 6854-6860
   Abstract »    Full Text »    PDF »
Proteogenomics: needs and roles to be filled by proteomics in genome annotation.
C. Ansong, S. O. Purvine, J. N. Adkins, M. S. Lipton, and R. D. Smith (2008)
Brief Funct Genomic Proteomic
   Abstract »    Full Text »    PDF »
Factors and Selenocysteine Insertion Sequence Requirements for the Synthesis of Selenoproteins from a Gram-Positive Anaerobe in Escherichia coli.
T. Gursinsky, D. Grobe, A. Schierhorn, J. Jager, J. R. Andreesen, and B. Sohling (2008)
Appl. Envir. Microbiol. 74, 1385-1393
   Abstract »    Full Text »    PDF »
Structure and Catalytic Mechanism of Eukaryotic Selenocysteine Synthase.
O. M. Ganichkin, X.-M. Xu, B. A. Carlson, H. Mix, D. L. Hatfield, V. N. Gladyshev, and M. C. Wahl (2008)
J. Biol. Chem. 283, 5849-5865
   Abstract »    Full Text »    PDF »
Brazil nuts: an effective way to improve selenium status.
C. D Thomson, A. Chisholm, S. K McLachlan, and J. M Campbell (2008)
Am. J. Clinical Nutrition 87, 379-384
   Abstract »    Full Text »    PDF »
Comparative Analysis of Selenocysteine Machinery and Selenoproteome Gene Expression in Mouse Brain Identifies Neurons as Key Functional Sites of Selenium in Mammals.
Y. Zhang, Y. Zhou, U. Schweizer, N. E. Savaskan, D. Hua, J. Kipnis, D. L. Hatfield, and V. N. Gladyshev (2008)
J. Biol. Chem. 283, 2427-2438
   Abstract »    Full Text »    PDF »
Deletion of the Selenocysteine tRNA Gene in Macrophages and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by Nrf2.
T. Suzuki, V. P. Kelly, H. Motohashi, O. Nakajima, S. Takahashi, S. Nishimura, and M. Yamamoto (2008)
J. Biol. Chem. 283, 2021-2030
   Abstract »    Full Text »    PDF »
SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.
S. Castellano, V. N. Gladyshev, R. Guigo, and M. J. Berry (2008)
Nucleic Acids Res. 36, D332-D338
   Abstract »    Full Text »    PDF »
Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes.
V. Pagmantidis, C. Meplan, E. M van Schothorst, J. Keijer, and J. E Hesketh (2008)
Am. J. Clinical Nutrition 87, 181-189
   Abstract »    Full Text »    PDF »
Solution Structure of Selenoprotein W and NMR Analysis of Its Interaction with 14-3-3 Proteins.
F. L. Aachmann, D. E. Fomenko, A. Soragni, V. N. Gladyshev, and A. Dikiy (2007)
J. Biol. Chem. 282, 37036-37044
   Abstract »    Full Text »    PDF »
miRRim: A novel system to find conserved miRNAs with high sensitivity and specificity.
G. Terai, T. Komori, K. Asai, and T. Kin (2007)
RNA 13, 2081-2090
   Abstract »    Full Text »    PDF »
Selective Restoration of the Selenoprotein Population in a Mouse Hepatocyte Selenoproteinless Background with Different Mutant Selenocysteine tRNAs Lacking Um34.
B. A. Carlson, M. E. Moustafa, A. Sengupta, U. Schweizer, R. Shrimali, M. Rao, N. Zhong, S. Wang, L. Feigenbaum, B. J. Lee, et al. (2007)
J. Biol. Chem. 282, 32591-32602
   Abstract »    Full Text »    PDF »
A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation.
P. R. Hoffmann, C. Jourdan-Le Saux, F. W. Hoffmann, P. S. Chang, O. Bollt, Q. He, E. K. Tam, and M. J. Berry (2007)
J. Immunol. 179, 3258-3267
   Abstract »    Full Text »    PDF »
Selenium status alters tumour differentiation but not incidence or latency of pancreatic adenocarcinomas in Ela-TGF-{alpha} p53+/ mice.
M. Aichler, H. Algul, D. Behne, G. Holzlwimmer, B. Michalke, L. Quintanilla-Martinez, J. Schmidt, R. M. Schmid, and M. Brielmeier (2007)
Carcinogenesis 28, 2002-2007
   Abstract »    Full Text »    PDF »
Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif.
V. A. Shchedrina, S. V. Novoselov, M. Yu. Malinouski, and V. N. Gladyshev (2007)
PNAS 104, 13919-13924
   Abstract »    Full Text »    PDF »
Selenoprotein H Is a Redox-sensing High Mobility Group Family DNA-binding Protein That Up-regulates Genes Involved in Glutathione Synthesis and Phase II Detoxification.
J. Panee, Z. R. Stoytcheva, W. Liu, and M. J. Berry (2007)
J. Biol. Chem. 282, 23759-23765
   Abstract »    Full Text »    PDF »
High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis.
Y. Zhang and V. N. Gladyshev (2007)
Nucleic Acids Res. 35, 4952-4963
   Abstract »    Full Text »    PDF »
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.
J. Lu, E.-H. Chew, and A. Holmgren (2007)
PNAS 104, 12288-12293
   Abstract »    Full Text »    PDF »
The Anti-inflammatory Effects of Selenium Are Mediated through 15-Deoxy-{Delta}12,14-prostaglandin J2 in Macrophages.
H. Vunta, F. Davis, U. D. Palempalli, D. Bhat, R. J. Arner, J. T. Thompson, D. G. Peterson, C. C. Reddy, and K. S. Prabhu (2007)
J. Biol. Chem. 282, 17964-17973
   Abstract »    Full Text »    PDF »
The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.
P. R. Hoffmann, S. C. Hoge, P.-A. Li, F. W. Hoffmann, A. C. Hashimoto, and M. J. Berry (2007)
Nucleic Acids Res. 35, 3963-3973
   Abstract »    Full Text »    PDF »
Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed.
R. F. Burk, K. E. Hill, G. E. Olson, E. J. Weeber, A. K. Motley, V. P. Winfrey, and L. M. Austin (2007)
J. Neurosci. 27, 6207-6211
   Abstract »    Full Text »    PDF »
A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.
M.-H. Yoo, X.-M. Xu, A. A. Turanov, B. A. Carlson, V. N. Gladyshev, and D. L. Hatfield (2007)
RNA 13, 921-929
   Abstract »    Full Text »    PDF »
A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells.
S. V. Novoselov, A. V. Lobanov, D. Hua, M. V. Kasaikina, D. L. Hatfield, and V. N. Gladyshev (2007)
PNAS 104, 7857-7862
   Abstract »    Full Text »    PDF »
Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis.
G. E. Olson, V. P. Winfrey, S. K. NagDas, K. E. Hill, and R. F. Burk (2007)
J. Biol. Chem. 282, 12290-12297
   Abstract »    Full Text »    PDF »
Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern.
S. V. Novoselov, G. V. Kryukov, X.-M. Xu, B. A. Carlson, D. L. Hatfield, and V. N. Gladyshev (2007)
J. Biol. Chem. 282, 11960-11968
   Abstract »    Full Text »    PDF »
Extracellular Production of Hydrogen Selenide Accounts for Thiol-assisted Toxicity of Selenite against Saccharomyces cerevisiae.
A. Tarze, M. Dauplais, I. Grigoras, M. Lazard, N.-T. Ha-Duong, F. Barbier, S. Blanquet, and P. Plateau (2007)
J. Biol. Chem. 282, 8759-8767
   Abstract »    Full Text »    PDF »
An improved definition of the RNA-binding specificity of SECIS-binding protein 2, an essential component of the selenocysteine incorporation machinery.
A. Clery, V. Bourguignon-Igel, C. Allmang, A. Krol, and C. Branlant (2007)
Nucleic Acids Res. 35, 1868-1884
   Abstract »    Full Text »    PDF »
Identification and characterization of human ethanolaminephosphotransferase1.
Y. Horibata and Y. Hirabayashi (2007)
J. Lipid Res. 48, 503-508
   Abstract »    Full Text »    PDF »
Occurrence of Selenoprotein Enzyme Activities and mRNA in Bovine Mammary Tissue.
K. Bruzelius, T. Hoac, R. Sundler, G. Onning, and B. Akesson (2007)
J Dairy Sci 90, 918-927
   Abstract »    Full Text »    PDF »
SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.
H. Mix, A. V. Lobanov, and V. N. Gladyshev (2007)
Nucleic Acids Res. 35, 414-423
   Abstract »    Full Text »    PDF »
High-Throughput Identification of Catalytic Redox-Active Cysteine Residues.
D. E. Fomenko, W. Xing, B. M. Adair, D. J. Thomas, and V. N. Gladyshev (2007)
Science 315, 387-389
   Abstract »    Full Text »    PDF »
Serum selenium and risk of prostate cancer--a nested case-control study.
U. Peters, C. B Foster, N. Chatterjee, A. Schatzkin, D. Reding, G. L Andriole, E D. Crawford, S. Sturup, S. J Chanock, and R. B Hayes (2007)
Am. J. Clinical Nutrition 85, 209-217
   Abstract »    Full Text »    PDF »
The Biological Revolution: Understanding the Impact of SNPs on Diet-Cancer Interrelationships.
J. C. Mathers and J. E. Hesketh (2007)
J. Nutr. 137, 253S-258S
   Abstract »    Full Text »    PDF »
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.
J. Yuan, S. Palioura, J. C. Salazar, D. Su, P. O'Donoghue, M. J. Hohn, A. M. Cardoso, W. B. Whitman, and D. Soll (2006)
PNAS 103, 18923-18927
   Abstract »    Full Text »    PDF »
Selenium-Dependent Pre- and Posttranscriptional Mechanisms Are Responsible for Sexual Dimorphic Expression of Selenoproteins in Murine Tissues.
C. Riese, M. Michaelis, B. Mentrup, F. Gotz, J. Kohrle, U. Schweizer, and L. Schomburg (2006)
Endocrinology 147, 5883-5892
   Abstract »    Full Text »    PDF »
C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer..
E. E. Evans, A. D. Henn, A. Jonason, M. J. Paris, L. M. Schiffhauer, M. A. Borrello, E. S. Smith, D. M. Sahasrabudhe, and M. Zauderer (2006)
Mol. Cancer Ther. 5, 2919-2930
   Abstract »    Full Text »    PDF »
Selenoproteins and Their Impact on Human Health Through Diverse Physiological Pathways..
B. Moghadaszadeh and A. H. Beggs (2006)
Physiology 21, 307-315
   Abstract »    Full Text »    PDF »
Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.
A. V. Lobanov, S. Gromer, G. Salinas, and V. N. Gladyshev (2006)
Nucleic Acids Res. 34, 4012-4024
   Abstract »    Full Text »    PDF »
Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon.
M. Bauer-Marinovic, S. Florian, K. Muller-Schmehl, H. Glatt, and G. Jacobasch (2006)
Carcinogenesis 27, 1849-1859
   Abstract »    Full Text »    PDF »
Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner.
S. Abe-Dohmae, K. H. Kato, Y. Kumon, W. Hu, H. Ishigami, N. Iwamoto, M. Okazaki, C.-A. Wu, M. Tsujita, K. Ueda, et al. (2006)
J. Lipid Res. 47, 1542-1550
   Abstract »    Full Text »    PDF »
Characterization of Recombinant Xenopus laevis Type I Iodothyronine Deiodinase: Substitution of a Proline Residue in the Catalytic Center by Serine (Pro132Ser) Restores Sensitivity to 6-Propyl-2-Thiouracil.
G. G. J. M. Kuiper, W. Klootwijk, G. Morvan Dubois, O. Destree, V. M. Darras, S. Van der Geyten, B. Demeneix, and T. J. Visser (2006)
Endocrinology 147, 3519-3529
   Abstract »    Full Text »    PDF »
Redox Balance Mechanisms in Schistosoma mansoni Rely on Peroxiredoxins and Albumin and Implicate Peroxiredoxins as Novel Drug Targets.
A. A. Sayed, S. K. Cook, and D. L. Williams (2006)
J. Biol. Chem. 281, 17001-17010
   Abstract »    Full Text »    PDF »
Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model.
V. Diwadkar-Navsariwala, G. S. Prins, S. M. Swanson, L. A. Birch, V. H. Ray, S. Hedayat, D. L. Lantvit, and A. M. Diamond (2006)
PNAS 103, 8179-8184
   Abstract »    Full Text »    PDF »
Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells.
M.-H. Yoo, X.-M. Xu, B. A. Carlson, V. N. Gladyshev, and D. L. Hatfield (2006)
J. Biol. Chem. 281, 13005-13008
   Abstract »    Full Text »    PDF »
Both Selenoproteins and Low Molecular Weight Selenocompounds Reduce Colon Cancer Risk in Mice with Genetically Impaired Selenoprotein Expression.
R. Irons, B. A. Carlson, D. L. Hatfield, and C. D. Davis (2006)
J. Nutr. 136, 1311-1317
   Abstract »    Full Text »    PDF »
Selenium accumulation in prostate tissue during a randomized, controlled short-term trial of l-selenomethionine: a Southwest Oncology Group Study..
A. L. Sabichi, J. J. Lee, R. J. Taylor, I. M. Thompson, B. J. Miles, C. M. Tangen, L. M. Minasian, L. L. Pisters, J. R. Caton, J. W. Basler, et al. (2006)
Clin. Cancer Res. 12, 2178-2184
   Abstract »    Full Text »    PDF »
Synthesis and Metabolism of Thyroid Hormones Is Preferentially Maintained in Selenium-Deficient Transgenic Mice.
L. Schomburg, C. Riese, M. Michaelis, E. Griebert, M. O. Klein, R. Sapin, U. Schweizer, and J. Kohrle (2006)
Endocrinology 147, 1306-1313
   Abstract »    Full Text »    PDF »
NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family.
A. D. Ferguson, V. M. Labunskyy, D. E. Fomenko, D. Arac, Y. Chelliah, C. A. Amezcua, J. Rizo, V. N. Gladyshev, and J. Deisenhofer (2006)
J. Biol. Chem. 281, 3536-3543
   Abstract »    Full Text »    PDF »
The Plasmodium selenoproteome.
A. V. Lobanov, C. Delgado, S. Rahlfs, S. V. Novoselov, G. V. Kryukov, S. Gromer, D. L. Hatfield, K. Becker, and V. N. Gladyshev (2006)
Nucleic Acids Res. 34, 496-505
   Abstract »    Full Text »    PDF »
A periodic pattern of mRNA secondary structure created by the genetic code..
S. A. Shabalina, A. Y. Ogurtsov, and N. A. Spiridonov (2006)
Nucleic Acids Res. 34, 2428-2437
   Abstract »    Full Text »    PDF »
Sequence-based heuristics for faster annotation of non-coding RNA families.
Z. Weinberg and W. L. Ruzzo (2006)
Bioinformatics 22, 35-39
   Abstract »    Full Text »    PDF »
Evidence for Direct Roles of Two Additional Factors, SECp43 and Soluble Liver Antigen, in the Selenoprotein Synthesis Machinery.
X.-M. Xu, H. Mix, B. A. Carlson, P. J. Grabowski, V. N. Gladyshev, M. J. Berry, and D. L. Hatfield (2005)
J. Biol. Chem. 280, 41568-41575
   Abstract »    Full Text »    PDF »
Selenium, the Thyroid, and the Endocrine System.
J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont (2005)
Endocr. Rev. 26, 944-984
   Abstract »    Full Text »    PDF »
Characterization of an Iodothyronine 5'-Deiodinase in Gilthead Seabream (Sparus auratus) that Is Inhibited by Dithiothreitol.
P. H. M. Klaren, R. Haasdijk, J. R. Metz, L. M. C. Nitsch, V. M. Darras, S. Van der Geyten, and G. Flik (2005)
Endocrinology 146, 5621-5630
   Abstract »    Full Text »    PDF »
Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin.
A. N. Uddin, F. J. Burns, and T. G. Rossman (2005)
Carcinogenesis 26, 2179-2186
   Abstract »    Full Text »    PDF »
Allelic Loss of the Gene for the GPX1 Selenium-Containing Protein Is a Common Event in Cancer.
Y. Hu, R. V. Benya, R. E. Carroll, and A. M. Diamond (2005)
J. Nutr. 135, 3021S-3024S
   Abstract »    Full Text »    PDF »
A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase.
V. M. Labunskyy, A. D. Ferguson, D. E. Fomenko, Y. Chelliah, D. L. Hatfield, and V. N. Gladyshev (2005)
J. Biol. Chem. 280, 37839-37845
   Abstract »    Full Text »    PDF »
From the Cover: Diversity and functional plasticity of eukaryotic selenoproteins: Identification and characterization of the SelJ family.
S. Castellano, A. V. Lobanov, C. Chapple, S. V. Novoselov, M. Albrecht, D. Hua, A. Lescure, T. Lengauer, A. Krol, V. N. Gladyshev, et al. (2005)
PNAS 102, 16188-16193
   Abstract »    Full Text »    PDF »
Selenium and Mortality in the Elderly: Results from the EVA Study.
N. T. Akbaraly, J. Arnaud, I. Hininger-Favier, V. Gourlet, A.-M. Roussel, and C. Berr (2005)
Clin. Chem. 51, 2117-2123
   Abstract »    Full Text »    PDF »
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
B. N. Lilley and H. L. Ploegh (2005)
PNAS 102, 14296-14301
   Abstract »    Full Text »    PDF »
Brainstem Axonal Degeneration in Mice with Deletion of Selenoprotein P.
W. M. Valentine, K. E. Hill, L. M. Austin, H. L. Valentine, D. Goldowitz, and R. F. Burk (2005)
Toxicol Pathol 33, 570-576
   Abstract »    Full Text »    PDF »
Selenoprotein P Is Required for Mouse Sperm Development.
G. E. Olson, V. P. Winfrey, S. K. NagDas, K. E. Hill, and R. F. Burk (2005)
Biol Reprod 73, 201-211
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)