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Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
David McDonald,1Li Wu,2Stacy M. Bohks,3Vineet N. KewalRamani,2Derya Unutmaz,3Thomas J. Hope1*
Monocyte-derived dendritic cells (MDDCs) can efficiently bindand transfer HIV infectivity without themselves becoming infected.Using live-cell microscopy, we found that HIV was recruitedto sites of cell contact in MDDCs. Analysis of conjugates betweenMDDCs and T cells revealed that, in the absence of antigen-specificsignaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cellwere recruited to the interface while the MDDCs concentratedHIV to the same region. We propose that contact between dendriticcells and T cells facilitates transmission of HIV by locallyconcentrating virus, receptor, and coreceptor during the formationof an infectious synapse.
1 Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA. 2 HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA. 3 Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
* To whom correspondence should be addressed. E-mail: thope{at}uic.edu
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells.
C. Muratori, E. Ruggiero, A. Sistigu, R. Bona, and M. Federico (2009)
J. Gen. Virol.
90, 2777-2787
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse.
G. Vasiliver-Shamis, M. W. Cho, C. E. Hioe, and M. L. Dustin (2009)
J. Virol.
83, 11341-11355
|Abstract »|Full Text »|PDF »
HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase.
A. N. Harman, M. Kraus, C. R. Bye, K. Byth, S. G. Turville, O. Tang, S. K. Mercier, N. Nasr, J. L. Stern, B. Slobedman, et al. (2009)
Blood
114, 85-94
|Abstract »|Full Text »|PDF »
The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells.
M. Aubert, M. Yoon, D. D. Sloan, P. G. Spear, and K. R. Jerome (2009)
J. Virol.
83, 6171-6183
|Abstract »|Full Text »|PDF »
Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses.
D. Rudnicka, J. Feldmann, F. Porrot, S. Wietgrefe, S. Guadagnini, M.-C. Prevost, J. Estaquier, A. T. Haase, N. Sol-Foulon, and O. Schwartz (2009)
J. Virol.
83, 6234-6246
|Abstract »|Full Text »|PDF »
Intercellular Adhesion Molecule 1 (ICAM-1), but Not ICAM-2 and -3, Is Important for Dendritic Cell-Mediated Human Immunodeficiency Virus Type 1 Transmission.
Oligomerization of the Macrophage Mannose Receptor Enhances gp120-mediated Binding of HIV-1.
J. Lai, O. K. Bernhard, S. G. Turville, A. N. Harman, J. Wilkinson, and A. L. Cunningham (2009)
J. Biol. Chem.
284, 11027-11038
|Abstract »|Full Text »|PDF »
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses.
W. Hubner, G. P. McNerney, P. Chen, B. M. Dale, R. E. Gordon, F. Y. S. Chuang, X.-D. Li, D. M. Asmuth, T. Huser, and B. K. Chen (2009)
Science
323, 1743-1747
|Abstract »|Full Text »|PDF »
Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway.
N. Izquierdo-Useros, M. Naranjo-Gomez, J. Archer, S. C. Hatch, I. Erkizia, J. Blanco, F. E. Borras, M. C. Puertas, J. H. Connor, M. T. Fernandez-Figueras, et al. (2009)
Blood
113, 2732-2741
|Abstract »|Full Text »|PDF »
Efficient Replication of Human Immunodeficiency Virus Type 1 in Resting CD4+ T Lymphocytes Is Induced by Coculture with Autologous Dendritic Cells in the Absence of Foreign Antigens.
Plasminogen Activator Pla of Yersinia pestis Utilizes Murine DEC-205 (CD205) as a Receptor to Promote Dissemination.
S.-s. Zhang, C. G. Park, P. Zhang, S. S. Bartra, G. V. Plano, J. D. Klena, M. Skurnik, B. J. Hinnebusch, and T. Chen (2008)
J. Biol. Chem.
283, 31511-31521
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Envelope gp120 Induces a Stop Signal and Virological Synapse Formation in Noninfected CD4+ T Cells.
G. Vasiliver-Shamis, M. Tuen, T. W. Wu, T. Starr, T. O. Cameron, R. Thomson, G. Kaur, J. Liu, M. L. Visciano, H. Li, et al. (2008)
J. Virol.
82, 9445-9457
|Abstract »|Full Text »|PDF »
The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection.
I. B. Hogue, S. H. Bajaria, B. A. Fallert, S. Qin, T. A. Reinhart, and D. E. Kirschner (2008)
J. Gen. Virol.
89, 2228-2239
|Abstract »|Full Text »|PDF »
Virological Consequences of Early Events following Cell-Cell Contact between Human Immunodeficiency Virus Type 1-Infected and Uninfected CD4+ Cells.
E. Ruggiero, R. Bona, C. Muratori, and M. Federico (2008)
J. Virol.
82, 7773-7789
|Abstract »|Full Text »|PDF »
Dendritic Cells Preferentially Transfer CXCR4-Using Human Immunodeficiency Virus Type 1 Variants to CD4+ T Lymphocytes in trans.
T. van Montfort, A. A. M. Thomas, G. Pollakis, and W. A. Paxton (2008)
J. Virol.
82, 7886-7896
|Abstract »|Full Text »|PDF »
A Fusion Inhibitor Prevents Spread of Immunodeficiency Viruses, but Not Activation of Virus-Specific T Cells, by Dendritic Cells.
I. Frank, H. Stossel, A. Gettie, S. G. Turville, J. W. Bess Jr., J. D. Lifson, I. Sivin, N. Romani, and M. Robbiani (2008)
J. Virol.
82, 5329-5339
|Abstract »|Full Text »|PDF »
Human Dendritic Cell-Specific Intercellular Adhesion Molecule-Grabbing Nonintegrin (CD209) Is a Receptor for Yersinia pestis That Promotes Phagocytosis by Dendritic Cells.
P. Zhang, M. Skurnik, S.-S. Zhang, O. Schwartz, R. Kalyanasundaram, S. Bulgheresi, J. J. He, J. D. Klena, B. J. Hinnebusch, and T. Chen (2008)
Infect. Immun.
76, 2070-2079
|Abstract »|Full Text »|PDF »
Inhibitory Effect of PRO 2000, a Candidate Microbicide, on Dendritic Cell-Mediated Human Immunodeficiency Virus Transfer.
N. Teleshova, T. Chang, A. Profy, and M. E. Klotman (2008)
Antimicrob. Agents Chemother.
52, 1751-1758
|Abstract »|Full Text »|PDF »
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus.
M. D. Bobardt, G. Cheng, L. de Witte, S. Selvarajah, U. Chatterji, B. E. Sanders-Beer, T. B. H. Geijtenbeek, F. V. Chisari, and P. A. Gallay (2008)
PNAS
105, 5525-5530
|Abstract »|Full Text »|PDF »
The function of coreceptor as a basis for the kinetic dissection of HIV type 1 envelope protein-mediated cell fusion.
Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes.
N. Runkler, E. Dietzel, M. Moll, H.-D. Klenk, and A. Maisner (2008)
J. Gen. Virol.
89, 687-696
|Abstract »|Full Text »|PDF »
Feline immunodeficiency virus dendritic cell infection and transfer.
W. S. Sprague, M. Robbiani, P. R. Avery, K. P. O'Halloran, and E. A. Hoover (2008)
J. Gen. Virol.
89, 709-715
|Abstract »|Full Text »|PDF »
Dendritic Cells Are Less Susceptible to Human Immunodeficiency Virus Type 2 (HIV-2) Infection than to HIV-1 Infection.
M. G. Duvall, K. Lore, H. Blaak, D. A. Ambrozak, W. C. Adams, K. Santos, C. Geldmacher, J. R. Mascola, A. J. McMichael, A. Jaye, et al. (2007)
J. Virol.
81, 13486-13498
|Abstract »|Full Text »|PDF »
Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.
L. de Witte, M. Bobardt, U. Chatterji, G. Degeest, G. David, T. B. H. Geijtenbeek, and P. Gallay (2007)
PNAS
104, 19464-19469
|Abstract »|Full Text »|PDF »
Identification of an Arsenic-Sensitive Block to Primate Lentiviral Infection of Human Dendritic Cells.
M. Pion, R. Stalder, R. Correa, B. Mangeat, G. J. Towers, and V. Piguet (2007)
J. Virol.
81, 12086-12090
|Abstract »|Full Text »|PDF »
Characterization of Human Immunodeficiency Virus Type 1 Replication in Immature and Mature Dendritic Cells Reveals Dissociable cis- and trans-Infection.
C. Dong, A. M. Janas, J.-H. Wang, W. J. Olson, and L. Wu (2007)
J. Virol.
81, 11352-11362
|Abstract »|Full Text »|PDF »
Effects of feline immunodeficiency virus on feline monocyte-derived dendritic cells infected by spinoculation.
G. Freer, D. Matteucci, P. Mazzetti, F. Tarabella, V. Catalucci, and M. Bendinelli (2007)
J. Gen. Virol.
88, 2574-2582
|Abstract »|Full Text »|PDF »
Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells.
J.-H. Wang, A. M. Janas, W. J. Olson, and L. Wu (2007)
J. Virol.
81, 8933-8943
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Assembly, Budding, and Cell-Cell Spread in T Cells Take Place in Tetraspanin-Enriched Plasma Membrane Domains.
Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission.
N. Izquierdo-Useros, J. Blanco, I. Erkizia, M. T. Fernandez-Figueras, F. E. Borras, M. Naranjo-Gomez, M. Bofill, L. Ruiz, B. Clotet, and J. Martinez-Picado (2007)
J. Virol.
81, 7559-7570
|Abstract »|Full Text »|PDF »
Dendritic Cells Infected with vpr-Positive Human Immunodeficiency Virus Type 1 Induce CD8+ T-Cell Apoptosis via Upregulation of Tumor Necrosis Factor Alpha.
B. Majumder, N. J. Venkatachari, E. A. Schafer, M. L. Janket, and V. Ayyavoo (2007)
J. Virol.
81, 7388-7399
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Replication in Dendritic Cell-T-Cell Cocultures Is Increased upon Incorporation of Host LFA-1 due to Higher Levels of Virus Production in Immature Dendritic Cells.
C. Gilbert, R. Cantin, C. Barat, and M. J. Tremblay (2007)
J. Virol.
81, 7672-7682
|Abstract »|Full Text »|PDF »
Activated CD34-Derived Langerhans Cells Mediate Transinfection with Human Immunodeficiency Virus.
K. M. Fahrbach, S. M. Barry, S. Ayehunie, S. Lamore, M. Klausner, and T. J. Hope (2007)
J. Virol.
81, 6858-6868
|Abstract »|Full Text »|PDF »
IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells.
D. Wilflingseder, Z. Banki, E. Garcia, M. Pruenster, G. Pfister, B. Muellauer, D. S. Nikolic, C. Gassner, C. G. Ammann, M. P. Dierich, et al. (2007)
J. Immunol.
178, 7840-7848
|Abstract »|Full Text »|PDF »
In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53.
M. Deneka, A. Pelchen-Matthews, R. Byland, E. Ruiz-Mateos, and M. Marsh (2007)
J. Cell Biol.
177, 329-341
|Abstract »|Full Text »|PDF »
CD4 Coexpression Regulates DC-SIGN-Mediated Transmission of Human Immunodeficiency Virus Type 1.
J.-H. Wang, A. M. Janas, W. J. Olson, V. N. KewalRamani, and L. Wu (2007)
J. Virol.
81, 2497-2507
|Abstract »|Full Text »|PDF »
Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes.
P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin (2007)
J. Virol.
81, 2297-2306
|Abstract »|Full Text »|PDF »
Dendritic Cell-Mediated trans-Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN.
Relevance of DC-SIGN in DC-induced T cell proliferation.
K. Gijzen, P. J. Tacken, A. Zimmerman, B. Joosten, I. J. M. de Vries, C. G. Figdor, and R. Torensma (2007)
J. Leukoc. Biol.
81, 729-740
|Abstract »|Full Text »|PDF »
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes.
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay (2007)
J. Immunol.
178, 2862-2871
|Abstract »|Full Text »|PDF »
Efficient Capture of Antibody Neutralized HIV-1 by Cells Expressing DC-SIGN and Transfer to CD4+ T Lymphocytes.
T. van Montfort, A. A. Nabatov, T. B. H. Geijtenbeek, G. Pollakis, and W. A. Paxton (2007)
J. Immunol.
178, 3177-3185
|Abstract »|Full Text »|PDF »
Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.
A. L. Smith, L. Ganesh, K. Leung, J. Jongstra-Bilen, J. Jongstra, and G. J. Nabel (2007)
J. Exp. Med.
204, 421-430
|Abstract »|Full Text »|PDF »
T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif.
I. Bloch, F. J. Quintana, D. Gerber, T. Cohen, I. R. Cohen, and Y. Shai (2007)
FASEB J
21, 393-401
|Abstract »|Full Text »|PDF »
Inefficient Human Immunodeficiency Virus Replication in Mobile Lymphocytes.
M. Sourisseau, N. Sol-Foulon, F. Porrot, F. Blanchet, and O. Schwartz (2007)
J. Virol.
81, 1000-1012
|Abstract »|Full Text »|PDF »
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection.
M. Pion, A. Granelli-Piperno, B. Mangeat, R. Stalder, R. Correa, R. M. Steinman, and V. Piguet (2006)
J. Exp. Med.
203, 2887-2893
|Abstract »|Full Text »|PDF »
HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells.
A. N. Harman, J. Wilkinson, C. R. Bye, L. Bosnjak, J. L. Stern, M. Nicholle, J. Lai, and A. L. Cunningham (2006)
J. Immunol.
177, 7103-7113
|Abstract »|Full Text »|PDF »
The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.
M. G. Quaranta, B. Mattioli, L. Giordani, and M. Viora (2006)
FASEB J
20, 2198-2208
|Abstract »|Full Text »|PDF »
HIV interactions with dendritic cells: has our focus been too narrow?.
H. Donaghy, J. Wilkinson, and A. L. Cunningham (2006)
J. Leukoc. Biol.
80, 1001-1012
|Abstract »|Full Text »|PDF »
Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209).
P. Zhang, S. Snyder, P. Feng, P. Azadi, S. Zhang, S. Bulgheresi, K. E. Sanderson, J. He, J. Klena, and T. Chen (2006)
J. Immunol.
177, 4002-4011
|Abstract »|Full Text »|PDF »
Opposing roles of dendritic cell subsets in HIV-1 infection.
J. Stebbing and M. Bower (2006)
Blood
108, 1785-1786
|Full Text »|PDF »
Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition.
F. Groot, T. M. M. van Capel, M. L. Kapsenberg, B. Berkhout, and E. C. de Jong (2006)
Blood
108, 1957-1964
|Abstract »|Full Text »|PDF »
DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets..
C. Chaipan, E. J. Soilleux, P. Simpson, H. Hofmann, T. Gramberg, A. Marzi, M. Geier, E. A. Stewart, J. Eisemann, A. Steinkasserer, et al. (2006)
J. Virol.
80, 8951-8960
|Abstract »|Full Text »|PDF »
Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.
A. Moris, A. Pajot, F. Blanchet, F. Guivel-Benhassine, M. Salcedo, and O. Schwartz (2006)
Blood
108, 1643-1651
|Abstract »|Full Text »|PDF »
Dendritic Cells and HIV Infection: Activating Dendritic Cells to Boost Immunity.
N. Teleshova, J. Kenney, and M. Robbiani (2006)
Advances in Dental Research
19, 36-41
|Abstract »|Full Text »|PDF »
(C3) The Oral Epithelial Cell and First Encounters with HIV-1.
M.C. Herzberg, A. Weinberg, and S.M. Wahl (2006)
Advances in Dental Research
19, 158-166
|Abstract »|Full Text »|PDF »
DC-SIGN (CD209) recognition of Neisseria gonorrhoeae is circumvented by lipooligosaccharide variation.
P. Zhang, O. Schwartz, M. Pantelic, G. Li, Q. Knazze, C. Nobile, M. Radovich, J. He, S.-C. Hong, J. Klena, et al. (2006)
J. Leukoc. Biol.
79, 731-738
|Abstract »|Full Text »|PDF »
Infection of Dendritic Cells (DCs), Not DC-SIGN-Mediated Internalization of Human Immunodeficiency Virus, Is Required for Long-Term Transfer of Virus to T Cells.
L. Burleigh, P.-Y. Lozach, C. Schiffer, I. Staropoli, V. Pezo, F. Porrot, B. Canque, J.-L. Virelizier, F. Arenzana-Seisdedos, and A. Amara (2006)
J. Virol.
80, 2949-2957
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Fusion to Dendritic Cells Declines as Cells Mature.
M. Cavrois, J. Neidleman, J. F. Kreisberg, D. Fenard, C. Callebaut, and W. C. Greene (2006)
J. Virol.
80, 1992-1999
|Abstract »|Full Text »|PDF »
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection.
HIV-1 Selectively Infects a Subset of Nonmaturing BDCA1-Positive Dendritic Cells in Human Blood.
A. Granelli-Piperno, I. Shimeliovich, M. Pack, C. Trumpfheller, and R. M. Steinman (2006)
J. Immunol.
176, 991-998
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Can Establish Latent Infection in Resting CD4+ T Cells in the Absence of Activating Stimuli.
W. J. Swiggard, C. Baytop, J. J. Yu, J. Dai, C. Li, R. Schretzenmair, T. Theodosopoulos, and U. O'Doherty (2005)
J. Virol.
79, 14179-14188
|Abstract »|Full Text »|PDF »
Sugar-Binding Proteins Potently Inhibit Dendritic Cell Human Immunodeficiency Virus Type 1 (HIV-1) Infection and Dendritic-Cell-Directed HIV-1 Transfer.
S. G. Turville, K. Vermeire, J. Balzarini, and D. Schols (2005)
J. Virol.
79, 13519-13527
|Abstract »|Full Text »|PDF »
Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction.
A. Granelli-Piperno, A. Pritsker, M. Pack, I. Shimeliovich, J.-F. Arrighi, C. G. Park, C. Trumpfheller, V. Piguet, T. M. Moran, and R. M. Steinman (2005)
J. Immunol.
175, 4265-4273
|Abstract »|Full Text »|PDF »
Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells.
S. E. VanCompernolle, R. J. Taylor, K. Oswald-Richter, J. Jiang, B. E. Youree, J. H. Bowie, M. J. Tyler, J. M. Conlon, D. Wade, C. Aiken, et al. (2005)
J. Virol.
79, 11598-11606
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Virological Synapse Formation in T Cells Requires Lipid Raft Integrity.
HIV-1-infected Blood Mononuclear Cells Form an Integrin- and Agrin-dependent Viral Synapse to Induce Efficient HIV-1 Transcytosis across Epithelial Cell Monolayer.
A. Alfsen, H. Yu, A. Magerus-Chatinet, A. Schmitt, and M. Bomsel (2005)
Mol. Biol. Cell
16, 4267-4279
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus Type 1 Vpr Impairs Dendritic Cell Maturation and T-Cell Activation: Implications for Viral Immune Escape.
B. Majumder, M. L. Janket, E. A. Schafer, K. Schaubert, X.-L. Huang, J. Kan-Mitchell, C. R. Rinaldo Jr., and V. Ayyavoo (2005)
J. Virol.
79, 7990-8003
|Abstract »|Full Text »|PDF »
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells.
K. Lore, A. Smed-Sorensen, J. Vasudevan, J. R. Mascola, and R. A. Koup (2005)
J. Exp. Med.
201, 2023-2033
|Abstract »|Full Text »|PDF »
Neisseria gonorrhoeae Enhances Infection of Dendritic Cells by HIV Type 1.
J. Zhang, G. Li, A. Bafica, M. Pantelic, P. Zhang, H. Broxmeyer, Y. Liu, L. Wetzler, J. J. He, and T. Chen (2005)
J. Immunol.
174, 7995-8002
|Abstract »|Full Text »|PDF »
Mutational Analysis of Bovine Leukemia Virus Rex: Identification of a Dominant-Negative Inhibitor.
Covert Human Immunodeficiency Virus Replication in Dendritic Cells and in DC-SIGN-Expressing Cells Promotes Long-Term Transmission to Lymphocytes.
C. Nobile, C. Petit, A. Moris, K. Skrabal, J.-P. Abastado, F. Mammano, and O. Schwartz (2005)
J. Virol.
79, 5386-5399
|Abstract »|Full Text »|PDF »
Impaired Accessory Cell Function in a Human Dendritic Cell Line after Human Immunodeficiency Virus Infection.
P. Beuria, H. Chen, M. Timoney, and K. Sperber (2005)
Clin. Vaccine Immunol.
12, 453-464
|Abstract »|Full Text »|PDF »
The Core Lipopolysaccharide of Escherichia coli Is a Ligand for the Dendritic-Cell-Specific Intercellular Adhesion Molecule Nonintegrin CD209 Receptor.
J. Klena, P. Zhang, O. Schwartz, S. Hull, and T. Chen (2005)
J. Bacteriol.
187, 1710-1715
|Abstract »|Full Text »|PDF »
Lactoferrin Prevents Dendritic Cell-Mediated Human Immunodeficiency Virus Type 1 Transmission by Blocking the DC-SIGN--gp120 Interaction.
F. Groot, T. B. H. Geijtenbeek, R. W. Sanders, C. E. Baldwin, M. Sanchez-Hernandez, R. Floris, Y. van Kooyk, E. C. de Jong, and B. Berkhout (2005)
J. Virol.
79, 3009-3015
|Abstract »|Full Text »|PDF »
Long-Term Productive Human Immunodeficiency Virus Infection of CD1a-Sorted Myeloid Dendritic Cells.
S. Popov, A.-L. Chenine, A. Gruber, P.-L. Li, and R. M. Ruprecht (2005)
J. Virol.
79, 602-608
|Abstract »|Full Text »|PDF »
HIV-1-Induced Migration of Monocyte-Derived Dendritic Cells Is Associated with Differential Activation of MAPK Pathways.
D. Wilflingseder, B. Mullauer, H. Schramek, Z. Banki, M. Pruenster, M. P. Dierich, and H. Stoiber (2004)
J. Immunol.
173, 7497-7505
|Abstract »|Full Text »|PDF »
High Level of Coreceptor-independent HIV Transfer Induced by Contacts between Primary CD4 T Cells.
J. Blanco, B. Bosch, M. T. Fernandez-Figueras, J. Barretina, B. Clotet, and J. A. Este (2004)
J. Biol. Chem.
279, 51305-51314
|Abstract »|Full Text »|PDF »
DC-SIGN-mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells.
J.-F. Arrighi, M. Pion, E. Garcia, J.-M. Escola, Y. van Kooyk, T. B. Geijtenbeek, and V. Piguet (2004)
J. Exp. Med.
200, 1279-1288
|Abstract »|Full Text »|PDF »
Endocytic Host Cell Machinery Plays a Dominant Role in Intracellular Trafficking of Incoming Human Immunodeficiency Virus Type 1 in Human Placental Trophoblasts.
G. Vidricaire, M. Imbeault, and M. J. Tremblay (2004)
J. Virol.
78, 11904-11915
|Abstract »|Full Text »|PDF »
Infection of Specific Dendritic Cells by CCR5-Tropic Human Immunodeficiency Virus Type 1 Promotes Cell-Mediated Transmission of Virus Resistant to Broadly Neutralizing Antibodies.
L. Ganesh, K. Leung, K. Lore, R. Levin, A. Panet, O. Schwartz, R. A. Koup, and G. J. Nabel (2004)
J. Virol.
78, 11980-11987
|Abstract »|Full Text »|PDF »
DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus.
A. Marzi, T. Gramberg, G. Simmons, P. Moller, A. J. Rennekamp, M. Krumbiegel, M. Geier, J. Eisemann, N. Turza, B. Saunier, et al. (2004)
J. Virol.
78, 12090-12095
|Abstract »|Full Text »|PDF »
Lentivirus-Mediated RNA Interference of DC-SIGN Expression Inhibits Human Immunodeficiency Virus Transmission from Dendritic Cells to T Cells.
J.-F. Arrighi, M. Pion, M. Wiznerowicz, T. B. Geijtenbeek, E. Garcia, S. Abraham, F. Leuba, V. Dutoit, O. Ducrey-Rundquist, Y. van Kooyk, et al. (2004)
J. Virol.
78, 10848-10855
|Abstract »|Full Text »|PDF »
pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN.
Z.-Y. Yang, Y. Huang, L. Ganesh, K. Leung, W.-P. Kong, O. Schwartz, K. Subbarao, and G. J. Nabel (2004)
J. Virol.
78, 5642-5650
|Abstract »|Full Text »|PDF »
Where Does HIV Live?.
J. Stebbing, B. Gazzard, and D. C. Douek (2004)
N. Engl. J. Med.
350, 1872-1880
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Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes.
C. Maranon, J.-F. Desoutter, G. Hoeffel, W. Cohen, D. Hanau, and A. Hosmalin (2004)
PNAS
101, 6092-6097
|Abstract »|Full Text »|PDF »
HIV Transmission: Closing All the Doors.
C. W. Davis and R. W. Doms (2004)
J. Exp. Med.
199, 1037-1040
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A. Moris, C. Nobile, F. Buseyne, F. Porrot, J.-P. Abastado, and O. Schwartz (2004)
Blood
103, 2648-2654
|Abstract »|Full Text »|PDF »
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
S. G. Turville, J. J. Santos, I. Frank, P. U. Cameron, J. Wilkinson, M. Miranda-Saksena, J. Dable, H. Stossel, N. Romani, M. Piatak Jr, et al. (2004)
Blood
103, 2170-2179
|Abstract »|Full Text »|PDF »
HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse.
C. Jolly, K. Kashefi, M. Hollinshead, and Q. J. Sattentau (2004)
J. Exp. Med.
199, 283-293
|Abstract »|Full Text »|PDF »
Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus.
D. Burzyn, J. C. Rassa, D. Kim, I. Nepomnaschy, S. R. Ross, and I. Piazzon (2004)
J. Virol.
78, 576-584
|Abstract »|Full Text »|PDF »
DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection in trans of Simian Immunodeficiency Virus SIVagm.
M. J.-Y. Ploquin, O. M. Diop, N. Sol-Foulon, L. Mortara, A. Faye, M. A. Soares, E. Nerrienet, R. Le Grand, Y. Van Kooyk, A. Amara, et al. (2004)
J. Virol.
78, 798-810
|Abstract »|Full Text »|PDF »
Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways.
Q. Dang, J. Chen, D. Unutmaz, J. M. Coffin, V. K. Pathak, D. Powell, V. N. KewalRamani, F. Maldarelli, and W.-S. Hu (2004)
PNAS
101, 632-637
|Abstract »|Full Text »|PDF »
Macrophage HIV-1 infection and the gastrointestinal tract reservoir.
P. D. Smith, G. Meng, J. F. Salazar-Gonzalez, and G. M. Shaw (2003)
J. Leukoc. Biol.
74, 642-649
|Abstract »|Full Text »|PDF »
