Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 May 2003:
Vol. 300. no. 5620, pp. 805 - 808
DOI: 10.1126/science.1082320
Prev | Table of Contents | Next

Reports

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

Ujwal Sheth and Roy Parker*

A major pathway of eukaryotic messenger RNA (mRNA) turnover begins with deadenylation, followed by decapping and 5' to 3' exonucleolytic decay. We provide evidence that mRNA decapping and 5' to 3' degradation occur in discrete cytoplasmic foci in yeast, which we call processing bodies (P bodies). First, proteins that activate or catalyze decapping are concentrated in P bodies. Second, inhibiting mRNA turnover before decapping leads to loss of P bodies; however, inhibiting turnover at, or after, decapping, increases the abundance and size of P bodies. Finally, mRNA degradation intermediates are localized to P bodies. These results define the fluxof mRNAs between polysomes and P bodies as a critical aspect of cytoplasmic mRNA metabolism and a possible site for regulation of mRNA degradation.

Department of Molecular and Cellular Biology & Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA

* To whom correspondence should be addressed. E-mail: rrparker{at}u.arizona.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Processing bodies are not required for mammalian nonsense-mediated mRNA decay.
L. Stalder and O. Muhlemann (2009)
RNA 15, 1265-1273
   Abstract »    Full Text »    PDF »
Robust heat shock induces eIF2{alpha}-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.
T. Grousl, P. Ivanov, I. Frydlova, P. Vasicova, F. Janda, J. Vojtova, K. Malinska, I. Malcova, L. Novakova, D. Janoskova, et al. (2009)
J. Cell Sci. 122, 2078-2088
   Abstract »    Full Text »    PDF »
Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae.
L. Romero-Santacreu, J. Moreno, J. E. Perez-Ortin, and P. Alepuz (2009)
RNA 15, 1110-1120
   Abstract »    Full Text »    PDF »
The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.
A. Szakmary, M. Reedy, H. Qi, and H. Lin (2009)
J. Cell Biol. 185, 613-627
   Abstract »    Full Text »    PDF »
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.
S. L. Lian, S. Li, G. X. Abadal, B. A. Pauley, M. J. Fritzler, and E. K.L. Chan (2009)
RNA 15, 804-813
   Abstract »    Full Text »    PDF »
Stm1 Modulates mRNA Decay and Dhh1 Function in Saccharomyces cerevisiae.
V. Balagopal and R. Parker (2009)
Genetics 181, 93-103
   Abstract »    Full Text »    PDF »
Cells Lacking the Fragile X Mental Retardation Protein (FMRP) have Normal RISC Activity but Exhibit Altered Stress Granule Assembly.
M.-C. Didiot, M. Subramanian, E. Flatter, J.-L. Mandel, and H. Moine (2009)
Mol. Biol. Cell 20, 428-437
   Abstract »    Full Text »    PDF »
Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing.
S. Li, S. L. Lian, J. J. Moser, M. L. Fritzler, M. J. Fritzler, M. Satoh, and E. K. L. Chan (2008)
J. Cell Sci. 121, 4134-4144
   Abstract »    Full Text »    PDF »
Interaction with 14-3-3 Adaptors Regulates the Sorting of hMex-3B RNA-binding Protein to Distinct Classes of RNA Granules.
J. Courchet, K. Buchet-Poyau, A. Potemski, A. Bres, I. Jariel-Encontre, and M. Billaud (2008)
J. Biol. Chem. 283, 32131-32142
   Abstract »    Full Text »    PDF »
P bodies promote stress granule assembly in Saccharomyces cerevisiae.
J. R. Buchan, D. Muhlrad, and R. Parker (2008)
J. Cell Biol. 183, 441-455
   Abstract »    Full Text »    PDF »
A Novel Class of mRNA-containing Cytoplasmic Granules Are Produced in Response to UV-Irradiation.
H. Gaillard and A. Aguilera (2008)
Mol. Biol. Cell 19, 4980-4992
   Abstract »    Full Text »    PDF »
Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.
D. Zheng, N. Ezzeddine, C.-Y. A. Chen, W. Zhu, X. He, and A.-B. Shyu (2008)
J. Cell Biol. 182, 89-101
   Abstract »    Full Text »    PDF »
The Cth2 ARE-binding Protein Recruits the Dhh1 Helicase to Promote the Decay of Succinate Dehydrogenase SDH4 mRNA in Response to Iron Deficiency.
E. Pedro-Segura, S. V. Vergara, S. Rodriguez-Navarro, R. Parker, D. J. Thiele, and S. Puig (2008)
J. Biol. Chem. 283, 28527-28535
   Abstract »    Full Text »    PDF »
Zinc as a translation regulator in neurons: implications for P-body aggregation.
J. Blumenthal and I. Ginzburg (2008)
J. Cell Sci. 121, 3253-3260
   Abstract »    Full Text »    PDF »
Crystal Structure of Human Edc3 and Its Functional Implications.
S. H. M. Ling, C. J. Decker, M. A. Walsh, M. She, R. Parker, and H. Song (2008)
Mol. Cell. Biol. 28, 5965-5976
   Abstract »    Full Text »    PDF »
The T Body, a New Cytoplasmic RNA Granule in Saccharomyces cerevisiae.
F. Malagon and T. H. Jensen (2008)
Mol. Cell. Biol. 28, 6022-6032
   Abstract »    Full Text »    PDF »
lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.
A. Chowdhury and S. Tharun (2008)
RNA 14, 2149-2158
   Abstract »    Full Text »    PDF »
Translationally Repressed mRNA Transiently Cycles through Stress Granules during Stress.
S. Mollet, N. Cougot, A. Wilczynska, F. Dautry, M. Kress, E. Bertrand, and D. Weil (2008)
Mol. Biol. Cell 19, 4469-4479
   Abstract »    Full Text »    PDF »
The Dynamics of Mammalian P Body Transport, Assembly, and Disassembly In Vivo.
A. Aizer, Y. Brody, L. W. Ler, N. Sonenberg, R. H. Singer, and Y. Shav-Tal (2008)
Mol. Biol. Cell 19, 4154-4166
   Abstract »    Full Text »    PDF »
Maternal Argonaute 2 Is Essential for Early Mouse Development at the Maternal-Zygotic Transition.
K. Lykke-Andersen, M. J. Gilchrist, J. B. Grabarek, P. Das, E. Miska, and M. Zernicka-Goetz (2008)
Mol. Biol. Cell 19, 4383-4392
   Abstract »    Full Text »    PDF »
Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2{alpha} phosphorylation at Thr169.
S. Kramer, R. Queiroz, L. Ellis, H. Webb, J. D. Hoheisel, C. Clayton, and M. Carrington (2008)
J. Cell Sci. 121, 3002-3014
   Abstract »    Full Text »    PDF »
Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast.
S. Takahashi, Y. Araki, Y. Ohya, T. Sakuno, S.-I. Hoshino, K. Kontani, H. Nishina, and T. Katada (2008)
RNA 14, 1950-1958
   Abstract »    Full Text »    PDF »
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.
P. R. Boag, A. Atalay, S. Robida, V. Reinke, and T. K. Blackwell (2008)
J. Cell Biol. 182, 543-557
   Abstract »    Full Text »    PDF »
A role for Q/N-rich aggregation-prone regions in P-body localization.
M. A. M. Reijns, R. D. Alexander, M. P. Spiller, and J. D. Beggs (2008)
J. Cell Sci. 121, 2463-2472
   Abstract »    Full Text »    PDF »
Synthetic Genetic Array Analysis in Saccharomyces cerevisiae Provides Evidence for an Interaction Between RAT8/DBP5 and Genes Encoding P-Body Components.
J. J. Scarcelli, S. Viggiano, C. A. Hodge, C. V. Heath, D. C. Amberg, and C. N. Cole (2008)
Genetics 179, 1945-1955
   Abstract »    Full Text »    PDF »
S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex.
L. M. Rendl, M. A. Bieman, and C. A. Smibert (2008)
RNA 14, 1328-1336
   Abstract »    Full Text »    PDF »
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.
K. Nykamp, M.-H. Lee, and J. Kimble (2008)
RNA 14, 1378-1389
   Abstract »    Full Text »    PDF »
Poly(rC) Binding Proteins and the 5' Cloverleaf of Uncapped Poliovirus mRNA Function during De Novo Assembly of Polysomes.
B. J. Kempf and D. J. Barton (2008)
J. Virol. 82, 5835-5846
   Abstract »    Full Text »    PDF »
CaSm (LSm-1) Overexpression in Lung Cancer and Mesothelioma Is Required for Transformed Phenotypes.
P. M. Watson, S. W. Miller, M. Fraig, D. J. Cole, D. K. Watson, and A. M. Boylan (2008)
Am. J. Respir. Cell Mol. Biol. 38, 671-678
   Abstract »    Full Text »    PDF »
A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes.
J. A. M. Braks, G. R. Mair, B. Franke-Fayard, C. J. Janse, and A. P. Waters (2008)
Nucleic Acids Res. 36, 1176-1186
   Abstract »    Full Text »    PDF »
Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies.
K. Fujimura, F. Kano, and M. Murata (2008)
RNA 14, 425-431
   Abstract »    Full Text »    PDF »
Ty3 Nucleocapsid Controls Localization of Particle Assembly.
L. S. Z. Larsen, N. Beliakova-Bethell, V. Bilanchone, M. Zhang, A. Lamsa, R. DaSilva, G. W. Hatfield, K. Nagashima, and S. Sandmeyer (2008)
J. Virol. 82, 2501-2514
   Abstract »    Full Text »    PDF »
The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in Saccharomyces cerevisiae P-Bodies.
C. Beckham, A. Hilliker, A.-M. Cziko, A. Noueiry, M. Ramaswami, and R. Parker (2008)
Mol. Biol. Cell 19, 984-993
   Abstract »    Full Text »    PDF »
Pat1 Contains Distinct Functional Domains That Promote P-Body Assembly and Activation of Decapping.
G. R. Pilkington and R. Parker (2008)
Mol. Cell. Biol. 28, 1298-1312
   Abstract »    Full Text »    PDF »
The 90-kDa Heat Shock Protein Stabilizes the Polysomal Ribonuclease 1 mRNA Endonuclease to Degradation by the 26S Proteasome.
Y. Peng, X. Liu, and D. R. Schoenberg (2008)
Mol. Biol. Cell 19, 546-552
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Vif Functionally Interacts with Diverse APOBEC3 Cytidine Deaminases and Moves with Them between Cytoplasmic Sites of mRNA Metabolism.
M. Marin, S. Golem, K. M. Rose, S. L. Kozak, and D. Kabat (2008)
J. Virol. 82, 987-998
   Abstract »    Full Text »    PDF »
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
T. E. Mullen and W. F. Marzluff (2008)
Genes & Dev. 22, 50-65
   Abstract »    Full Text »    PDF »
CPEB Interacts with an Ovary-specific eIF4E and 4E-T in Early Xenopus Oocytes.
N. Minshall, M. H. Reiter, D. Weil, and N. Standart (2007)
J. Biol. Chem. 282, 37389-37401
   Abstract »    Full Text »    PDF »
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.
S. Kwon, Y. Zhang, and P. Matthias (2007)
Genes & Dev. 21, 3381-3394
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.
B. Luke, C. M. Azzalin, N. Hug, A. Deplazes, M. Peter, and J. Lingner (2007)
Nucleic Acids Res. 35, 7688-7697
   Abstract »    Full Text »    PDF »
3' Terminal oligo U-tract-mediated stimulation of decapping.
M.-G. Song and M. Kiledjian (2007)
RNA 13, 2356-2365
   Abstract »    Full Text »    PDF »
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae.
C. J. Decker, D. Teixeira, and R. Parker (2007)
J. Cell Biol. 179, 437-449
   Abstract »    Full Text »    PDF »
Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies.
N. P. Hoyle, L. M. Castelli, S. G. Campbell, L. E.A. Holmes, and M. P. Ashe (2007)
J. Cell Biol. 179, 65-74
   Abstract »    Full Text »    PDF »
The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.
R. Lotan, V. Goler-Baron, L. Duek, G. Haimovich, and M. Choder (2007)
J. Cell Biol. 178, 1133-1143
   Abstract »    Full Text »    PDF »
Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies.
S. Durand, N. Cougot, F. Mahuteau-Betzer, C.-H. Nguyen, D. S. Grierson, E. Bertrand, J. Tazi, and F. Lejeune (2007)
J. Cell Biol. 178, 1145-1160
   Abstract »    Full Text »    PDF »
Interactions between Brome Mosaic Virus RNAs and Cytoplasmic Processing Bodies.
C. J. Beckham, H. R. Light, T. Amar Nissan, P. Ahlquist, R. Parker, and A. Noueiry (2007)
J. Virol. 81, 9759-9768
   Abstract »    Full Text »    PDF »
Binding specificities of the GYF domains from two Saccharomyces cerevisiae Paralogs.
A. Georgiev, M. Sjostrom, and A. Wieslander (2007)
Protein Eng. Des. Sel.
   Abstract »    Full Text »    PDF »
De Novo Protein Synthesis Is Required for Lytic Cycle Reactivation of Epstein-Barr Virus, but Not Kaposi's Sarcoma-Associated Herpesvirus, in Response to Histone Deacetylase Inhibitors and Protein Kinase C Agonists.
J. Ye, L. Gradoville, D. Daigle, and G. Miller (2007)
J. Virol. 81, 9279-9291
   Abstract »    Full Text »    PDF »
PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo.
G. Yao, Y.-C. Chiang, C. Zhang, D. J. Lee, T. M. Laue, and C. L. Denis (2007)
Mol. Cell. Biol. 27, 6243-6253
   Abstract »    Full Text »    PDF »
Small Interfering RNA-mediated Silencing Induces Target-dependent Assembly of GW/P Bodies.
S. Lian, M. J. Fritzler, J. Katz, T. Hamazaki, N. Terada, M. Satoh, and E. K.L. Chan (2007)
Mol. Biol. Cell 18, 3375-3387
   Abstract »    Full Text »    PDF »
Metal Determines Efficiency and Substrate Specificity of the Nuclear NUDIX Decapping Proteins X29 and H29K (Nudt16).
B. A. Peculis, K. Reynolds, and M. Cleland (2007)
J. Biol. Chem. 282, 24792-24805
   Abstract »    Full Text »    PDF »
GW body disassembly triggered by siRNAs independently of their silencing activity.
A. Serman, F. Le Roy, C. Aigueperse, M. Kress, F. Dautry, and D. Weil (2007)
Nucleic Acids Res. 35, 4715-4727
   Abstract »    Full Text »    PDF »
Localization of AU-rich Element-containing mRNA in Cytoplasmic Granules Containing Exosome Subunits.
W.-J. Lin, A. Duffy, and C.-Y. Chen (2007)
J. Biol. Chem. 282, 19958-19968
   Abstract »    Full Text »    PDF »
The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs.
A. Chowdhury, J. Mukhopadhyay, and S. Tharun (2007)
RNA 13, 998-1016
   Abstract »    Full Text »    PDF »
Ty3 Capsid Mutations Reveal Early and Late Functions of the Amino-Terminal Domain.
L. S. Z. Larsen, M. Zhang, N. Beliakova-Bethell, V. Bilanchone, A. Lamsa, K. Nagashima, R. Najdi, K. Kosaka, V. Kovacevic, J. Cheng, et al. (2007)
J. Virol. 81, 6957-6972
   Abstract »    Full Text »    PDF »
Host Factors That Control Long Terminal Repeat Retrotransposons in Saccharomyces cerevisiae: Implications for Regulation of Mammalian Retroviruses.
P. H. Maxwell and M. J. Curcio (2007)
Eukaryot. Cell 6, 1069-1080
   Full Text »    PDF »
Accumulation of Polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-Bodies in Saccharomyces cerevisiae.
M. Brengues and R. Parker (2007)
Mol. Biol. Cell 18, 2592-2602
   Abstract »    Full Text »    PDF »
P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing.
A. Eulalio, I. Behm-Ansmant, D. Schweizer, and E. Izaurralde (2007)
Mol. Cell. Biol. 27, 3970-3981
   Abstract »    Full Text »    PDF »
INCREASED SIZE EXCLUSION LIMIT2 Encodes a Putative DEVH Box RNA Helicase Involved in Plasmodesmata Function during Arabidopsis Embryogenesis.
K. Kobayashi, M. S. Otegui, S. Krishnakumar, M. Mindrinos, and P. Zambryski (2007)
PLANT CELL 19, 1885-1897
   Abstract »    Full Text »    PDF »
Analysis of P-Body Assembly in Saccharomyces cerevisiae.
D. Teixeira and R. Parker (2007)
Mol. Biol. Cell 18, 2274-2287
   Abstract »    Full Text »    PDF »
The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme.
A. T. Jonstrup, K. R. Andersen, L. B. Van, and D. E. Brodersen (2007)
Nucleic Acids Res. 35, 3153-3164
   Abstract »    Full Text »    PDF »
Probing the mRNA processing body using protein macroarrays and "autoantigenomics".
W.-H. Yang and D. B. Bloch (2007)
RNA 13, 704-712
   Abstract »    Full Text »    PDF »
Molecular Composition of IMP1 Ribonucleoprotein Granules.
L. Jonson, J. Vikesaa, A. Krogh, L. K. Nielsen, T. vO. Hansen, R. Borup, A. H. Johnsen, J. Christiansen, and F. C. Nielsen (2007)
Mol. Cell. Proteomics 6, 798-811
   Abstract »    Full Text »    PDF »
Components of the Arabidopsis mRNA Decapping Complex Are Required for Early Seedling Development.
D. C. Goeres, J. M. Van Norman, W. Zhang, N. A. Fauver, M. L. Spencer, and L. E. Sieburth (2007)
PLANT CELL 19, 1549-1564
   Abstract »    Full Text »    PDF »
The role of GW/P-bodies in RNA processing and silencing.
A. Jakymiw, K. M. Pauley, S. Li, K. Ikeda, S. Lian, T. Eystathioy, M. Satoh, M. J. Fritzler, and E. K. L. Chan (2007)
J. Cell Sci. 120, 1317-1323
   Abstract »    Full Text »    PDF »
A+U-Rich Instability Elements Differentially Activate 5'-3' and 3'-5' mRNA Decay.
E. L. Murray and D. R. Schoenberg (2007)
Mol. Cell. Biol. 27, 2791-2799
   Abstract »    Full Text »    PDF »
Microtubule disruption stimulates P-body formation.
T. J. Sweet, B. Boyer, W. Hu, K. E. Baker, and J. Coller (2007)
RNA 13, 493-502
   Abstract »    Full Text »    PDF »
In a tight spot: ARE-mRNAs at processing bodies.
G. Stoecklin and P. Anderson (2007)
Genes & Dev. 21, 627-631
   Full Text »    PDF »
TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.
T. M. Franks and J. Lykke-Andersen (2007)
Genes & Dev. 21, 719-735
   Abstract »    Full Text »    PDF »
Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules.
S. Gallois-Montbrun, B. Kramer, C. M. Swanson, H. Byers, S. Lynham, M. Ward, and M. H. Malim (2007)
J. Virol. 81, 2165-2178
   Abstract »    Full Text »    PDF »
Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.
K. Buchet-Poyau, J. Courchet, H. L. Hir, B. Seraphin, J.-Y. Scoazec, L. Duret, C. Domon-Dell, J.-N. Freund, and M. Billaud (2007)
Nucleic Acids Res. 35, 1289-1300
   Abstract »    Full Text »    PDF »
Packaging of the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Two Forms of the Vhs Polypeptide Are Associated with Intranuclear B and C Capsids, but Only One Is Associated with Enveloped Virions.
G. S. Read and M. Patterson (2007)
J. Virol. 81, 1148-1161
   Abstract »    Full Text »    PDF »
Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body.
M. E. Pepling, J. E. Wilhelm, A. L. O'Hara, G. W. Gephardt, and A. C. Spradling (2007)
PNAS 104, 187-192
   Abstract »    Full Text »    PDF »
How Do MicroRNAs Regulate Gene Expression?.
R. J. Jackson and N. Standart (2007)
Sci. STKE 2007, re1
   Abstract »    Full Text »    PDF »
RAP55, a Cytoplasmic mRNP Component, Represses Translation in Xenopus Oocytes.
K. J. Tanaka, K. Ogawa, M. Takagi, N. Imamoto, K. Matsumoto, and M. Tsujimoto (2006)
J. Biol. Chem. 281, 40096-40106
   Abstract »    Full Text »    PDF »
Polysome-Bound Endonuclease PMR1 Is Targeted to Stress Granules via Stress-Specific Binding to TIA-1.
F. Yang, Y. Peng, E. L. Murray, Y. Otsuka, N. Kedersha, and D. R. Schoenberg (2006)
Mol. Cell. Biol. 26, 8803-8813
   Abstract »    Full Text »    PDF »
Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation.
C.-H. Li, H. Irmer, D. Gudjonsdottir-Planck, S. Freese, H. Salm, S. Haile, A. M. Estevez, and C. Clayton (2006)
RNA 12, 2171-2186
   Abstract »    Full Text »    PDF »
Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1.
Y.-U. Park, H. Hur, M. Ka, and J. Kim (2006)
Eukaryot. Cell 5, 2120-2127
   Abstract »    Full Text »    PDF »
Nucleocytoplasmic Shuttling of the Rpb4p and Rpb7p Subunits of Saccharomyces cerevisiae RNA Polymerase II by Two Pathways.
M. Selitrennik, L. Duek, R. Lotan, and M. Choder (2006)
Eukaryot. Cell 5, 2092-2103
   Abstract »    Full Text »    PDF »
Arabidopsis DCP2, DCP1, and VARICOSE Form a Decapping Complex Required for Postembryonic Development.
J. Xu, J.-Y. Yang, Q.-W. Niu, and N.-H. Chua (2006)
PLANT CELL 18, 3386-3398
   Abstract »    Full Text »    PDF »
A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK.
M. Fawal, F. Armstrong, S. Ollier, H. Dupont, C. Touriol, B. Monsarrat, G. Delsol, B. Payrastre, and D. Morello (2006)
Blood 108, 2780-2788
   Abstract »    Full Text »    PDF »
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.
N. Deigendesch, F. Koch-Nolte, and S. Rothenburg (2006)
Nucleic Acids Res. 34, 5007-5020
   Abstract »    Full Text »    PDF »
Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae.
V. Hilgers, D. Teixeira, and R. Parker (2006)
RNA 12, 1835-1845
   Abstract »    Full Text »    PDF »
Control of cellular senescence by CPEB.
I. Groisman, M. Ivshina, V. Marin, N. J. Kennedy, R. J. Davis, and J. D. Richter (2006)
Genes & Dev. 20, 2701-2712
   Abstract »    Full Text »    PDF »
Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2{alpha} Phosphorylation.
R. Mazroui, R. Sukarieh, M.-E. Bordeleau, R. J. Kaufman, P. Northcote, J. Tanaka, I. Gallouzi, and J. Pelletier (2006)
Mol. Biol. Cell 17, 4212-4219
   Abstract »    Full Text »    PDF »
Determinants of Rbp1p Localization in Specific Cytoplasmic mRNA-processing Foci, P-bodies.
L.-T. Jang, L.-M. Buu, and F.-J. S. Lee (2006)
J. Biol. Chem. 281, 29379-29390
   Abstract »    Full Text »    PDF »
Rapid ATP-dependent Deadenylation of nanos mRNA in a Cell-free System from Drosophila Embryos.
M. Jeske, S. Meyer, C. Temme, D. Freudenreich, and E. Wahle (2006)
J. Biol. Chem. 281, 25124-25133
   Abstract »    Full Text »    PDF »
Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons..
S. Y. Grooms, K.-M. Noh, R. Regis, G. J. Bassell, M. K. Bryan, R. C. Carroll, and R. S. Zukin (2006)
J. Neurosci. 26, 8339-8351
   Abstract »    Full Text »    PDF »
Regulation of sexual development of Plasmodium by translational repression..
G. R. Mair, J. A. M. Braks, L. S. Garver, J. C. A. G. Wiegant, N. Hall, R. W. Dirks, S. M. Khan, G. Dimopoulos, C. J. Janse, and A. P. Waters (2006)
Science 313, 667-669
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)