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Science 25 April 2003:
Vol. 300. no. 5619, pp. 615 - 618
DOI: 10.1126/science.1078192
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Reports

Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles

Radoslav Savic,1 Laibin Luo,2 Adi Eisenberg,2 Dusica Maysinger1*

Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.

1 Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada.
2 Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, Canada.

* To whom correspondence should be addressed. E-mail: dmaysing{at}pharma.mcgill.ca

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