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Science 18 April 2003:
Vol. 300. no. 5618, pp. 502 - 505
DOI: 10.1126/science.1081203
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Reports

Axons Guided by Insulin Receptor in Drosophila Visual System

Jianbo Song,1 Lingling Wu,1 Zun Chen,1 Ronald A. Kohanski,1,2 Leslie Pick1*

Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.

1 Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
2 Department of Pediatrics and Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical School, Baltimore, MD 21287, USA.

* To whom correspondence should be addressed. E-mail: leslie.pick{at}mssm.edu

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