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Originally published in Science Express on 27 March 2003
Science 18 April 2003:
Vol. 300. no. 5618, pp. 482 - 486
DOI: 10.1126/science.1081846
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Reports

Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation

Brian H. Lee and Angelika Amon*

Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

* To whom correspondence should be addressed. E-mail: angelika{at}mit.edu

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