Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 April 2003:
Vol. 300. no. 5618, pp. 445 - 452
DOI: 10.1126/science.1083653
Prev | Table of Contents | Next

Review

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

Tony Pawson1,2* and Piers Nash1

The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation. However, this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior. The regulation of many different cellular processes requires the use of protein interaction domains to direct the association of polypeptides with one another and with phospholipids, small molecules, or nucleic acids. The modular nature of these domains, and the flexibility of their binding properties, have likely facilitated the evolution of cellular pathways. Conversely, aberrant interactions can induce abnormal cellular behavior and disease. The fundamental properties of protein interaction domains are discussed in this review and in detailed reviews on individual domains at Science's STKE at http://www.sciencemag.org/cgi/content/full/300/5618/445/DC1.

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
2 Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

* To whom correspondence should be addressed. E-mail: pawson{at}mshri.on.ca

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Eukaryotic Protein Domains as Functional Units of Cellular Evolution.
J. Jin, X. Xie, C. Chen, J. G. Park, C. Stark, D. A. James, M. Olhovsky, R. Linding, Y. Mao, and T. Pawson (2009)
Science Signaling 2, ra76
   Abstract »    Full Text »    PDF »
ELM: the status of the 2010 eukaryotic linear motif resource.
C. M. Gould, F. Diella, A. Via, P. Puntervoll, C. Gemund, S. Chabanis-Davidson, S. Michael, A. Sayadi, J. C. Bryne, C. Chica, et al. (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.
S. Antoku and B. J. Mayer (2009)
J. Cell Sci. 122, 4228-4238
   Abstract »    Full Text »    PDF »
The challenges of informatics in synthetic biology: from biomolecular networks to artificial organisms.
G. Alterovitz, T. Muso, and M. F. Ramoni (2009)
Brief Bioinform
   Abstract »    Full Text »    PDF »
PepX: a structural database of non-redundant protein-peptide complexes.
P. Vanhee, J. Reumers, F. Stricher, L. Baeten, L. Serrano, J. Schymkowitz, and F. Rousseau (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
The Ubiquitin-like Protein LC3 Regulates the Rho-GEF Activity of AKAP-Lbc.
L. Baisamy, S. Cavin, N. Jurisch, and D. Diviani (2009)
J. Biol. Chem. 284, 28232-28242
   Abstract »    Full Text »    PDF »
Knowledge-guided inference of domain-domain interactions from incomplete protein-protein interaction networks.
M. Liu, X.-w. Chen, and R. Jothi (2009)
Bioinformatics 25, 2492-2499
   Abstract »    Full Text »    PDF »
Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1p.
E. J. Stollar, B. Garcia, P. A. Chong, A. Rath, H. Lin, J. D. Forman-Kay, and A. R. Davidson (2009)
J. Biol. Chem. 284, 26918-26927
   Abstract »    Full Text »    PDF »
Rapid Evolution of Functional Complexity in a Domain Family.
A. Ernst, S. L. Sazinsky, S. Hui, B. Currell, M. Dharsee, S. Seshagiri, G. D. Bader, and S. S. Sidhu (2009)
Science Signaling 2, ra50
   Abstract »    Full Text »    PDF »
Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles.
D. Adhikari and K. Liu (2009)
Endocr. Rev. 30, 438-464
   Abstract »    Full Text »    PDF »
GAREM, a Novel Adaptor Protein for Growth Factor Receptor-bound Protein 2, Contributes to Cellular Transformation through the Activation of Extracellular Signal-regulated Kinase Signaling.
K. Tashiro, T. Tsunematsu, H. Okubo, T. Ohta, E. Sano, E. Yamauchi, H. Taniguchi, and H. Konishi (2009)
J. Biol. Chem. 284, 20206-20214
   Abstract »    Full Text »    PDF »
Analysis of Intracellular Substrates and Products of Thimet Oligopeptidase in Human Embryonic Kidney 293 Cells.
D. A. Berti, C. Morano, L. C. Russo, L. M. Castro, F. M. Cunha, X. Zhang, J. Sironi, C. F. Klitzke, E. S. Ferro, and L. D. Fricker (2009)
J. Biol. Chem. 284, 14105-14116
   Abstract »    Full Text »    PDF »
Sending Signals Dynamically.
R. G. Smock and L. M. Gierasch (2009)
Science 324, 198-203
   Abstract »    Full Text »    PDF »
Spatiotemporal Patterning During T Cell Activation Is Highly Diverse.
K. L. Singleton, K. T. Roybal, Y. Sun, G. Fu, N. R. J. Gascoigne, N. S. C. van Oers, and C. Wulfing (2009)
Science Signaling 2, ra15
   Abstract »    Full Text »    PDF »
Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels.
S. Dai, D. D. Hall, and J. W. Hell (2009)
Physiol Rev 89, 411-452
   Abstract »    Full Text »    PDF »
Characterization of Domain-Peptide Interaction Interface: A Generic Structure-based Model to Decipher the Binding Specificity of SH3 Domains.
T. Hou, Z. Xu, W. Zhang, W. A. McLaughlin, D. A. Case, Y. Xu, and W. Wang (2009)
Mol. Cell. Proteomics 8, 639-649
   Abstract »    Full Text »    PDF »
Raf Kinase Inhibitory Protein Function Is Regulated via a Flexible Pocket and Novel Phosphorylation-Dependent Mechanism.
A. E. Granovsky, M. C. Clark, D. McElheny, G. Heil, J. Hong, X. Liu, Y. Kim, G. Joachimiak, A. Joachimiak, S. Koide, et al. (2009)
Mol. Cell. Biol. 29, 1306-1320
   Abstract »    Full Text »    PDF »
3did Update: domain-domain and peptide-mediated interactions of known 3D structure.
A. Stein, A. Panjkovich, and P. Aloy (2009)
Nucleic Acids Res. 37, D300-D304
   Abstract »    Full Text »    PDF »
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.
T. Mittag, S. Orlicky, W.-Y. Choy, X. Tang, H. Lin, F. Sicheri, L. E. Kay, M. Tyers, and J. D. Forman-Kay (2008)
PNAS 105, 17772-17777
   Abstract »    Full Text »    PDF »
Illuminating signaling network functional biology through quantitative phosphoproteomic mass spectrometry.
N. C. Tedford, F. M. White, and J. A. Radding (2008)
Brief Funct Genomic Proteomic
   Abstract »    Full Text »    PDF »
Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer: Differential Epidermal Growth Factor Receptor (EGPR) Phosphorylation Events Associated with Mutated EGFR Compared with Wild Type.
A. J. VanMeter, A. S. Rodriguez, E. D. Bowman, J. Jen, C. C. Harris, J. Deng, V. S. Calvert, A. Silvestri, C. Fredolini, V. Chandhoke, et al. (2008)
Mol. Cell. Proteomics 7, 1902-1924
   Abstract »    Full Text »    PDF »
Intracellular Peptides as Natural Regulators of Cell Signaling.
F. M. Cunha, D. A. Berti, Z. S. Ferreira, C. F. Klitzke, R. P. Markus, and E. S. Ferro (2008)
J. Biol. Chem. 283, 24448-24459
   Abstract »    Full Text »    PDF »
Impacts of protein-protein interaction domains on organism and network complexity.
K. Xia, Z. Fu, L. Hou, and J.-D. J. Han (2008)
Genome Res. 18, 1500-1508
   Abstract »    Full Text »    PDF »
An integrative approach for predicting interactions of protein regions.
S.-E. Schelhorn, T. Lengauer, and M. Albrecht (2008)
Bioinformatics 24, i35-i41
   Abstract »    Full Text »    PDF »
Light-activated DNA binding in a designed allosteric protein.
D. Strickland, K. Moffat, and T. R. Sosnick (2008)
PNAS 105, 10709-10714
   Abstract »    Full Text »    PDF »
Profiling Protein Tyrosine Phosphorylation: A Quantitative 45-Plex Peptide-Based Immunoassay.
T. K. Nadler, C. Rauh-Adelmann, C. Murphy, A. B. Hall, J. R. Graham, L. Yen, N. F. Gordon, and J. A. Radding (2008)
J Biomol Screen 13, 626-637
   Abstract »    PDF »
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization.
Y. Yang, S. Yuzawa, and J. Schlessinger (2008)
PNAS 105, 7681-7686
   Abstract »    Full Text »    PDF »
Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.
L. Li, C. Wu, H. Huang, K. Zhang, J. Gan, and S. S.-C. Li (2008)
Nucleic Acids Res. 36, 3263-3273
   Abstract »    Full Text »    PDF »
PRINCESS, a Protein Interaction Confidence Evaluation System with Multiple Data Sources.
D. Li, W. Liu, Z. Liu, J. Wang, Q. Liu, Y. Zhu, and F. He (2008)
Mol. Cell. Proteomics 7, 1043-1052
   Abstract »    Full Text »    PDF »
Multiple Signals Regulate Phospholipase CBeta3 in Human Myometrial Cells.
M. Zhong, D. A. Murtazina, J. Phillips, C.-Y. Ku, and B. M. Sanborn (2008)
Biol Reprod 78, 1007-1017
   Abstract »    Full Text »    PDF »
Design of protein function leaps by directed domain interface evolution.
J. Huang, A. Koide, K. Makabe, and S. Koide (2008)
PNAS 105, 6578-6583
   Abstract »    Full Text »    PDF »
RPEL Motifs Link the Serum Response Factor Cofactor MAL but Not Myocardin to Rho Signaling via Actin Binding.
S. Guettler, M. K. Vartiainen, F. Miralles, B. Larijani, and R. Treisman (2008)
Mol. Cell. Biol. 28, 732-742
   Abstract »    Full Text »    PDF »
DIMA 2.0 predicted and known domain interactions.
P. Pagel, M. Oesterheld, O. Tovstukhina, N. Strack, V. Stumpflen, and D. Frishman (2008)
Nucleic Acids Res. 36, D651-D655
   Abstract »    Full Text »    PDF »
PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.
W. Gong, D. Zhou, Y. Ren, Y. Wang, Z. Zuo, Y. Shen, F. Xiao, Q. Zhu, A. Hong, X. Zhou, et al. (2008)
Nucleic Acids Res. 36, D679-D683
   Abstract »    Full Text »    PDF »
Regulation of TNF-{alpha}-activated PKC-{zeta} signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.
N. Lerner-Marmarosh, T. Miralem, P. E. M. Gibbs, and M. D. Maines (2007)
FASEB J 21, 3949-3962
   Abstract »    Full Text »    PDF »
Identification of Novel Membrane-binding Domains in Multiple Yeast Cdc42 Effectors.
S. Takahashi and P. M. Pryciak (2007)
Mol. Biol. Cell 18, 4945-4956
   Abstract »    Full Text »    PDF »
A photosensory two-component system regulates bacterial cell attachment.
E. B. Purcell, D. Siegal-Gaskins, D. C. Rawling, A. Fiebig, and S. Crosson (2007)
PNAS 104, 18241-18246
   Abstract »    Full Text »    PDF »
MyRIP Anchors Protein Kinase A to the Exocyst Complex.
A. S. Goehring, B. S. Pedroja, S. A. Hinke, L. K. Langeberg, and J. D. Scott (2007)
J. Biol. Chem. 282, 33155-33167
   Abstract »    Full Text »    PDF »
The role of peptide motifs in the evolution of a protein network.
H. Saito, S. Kashida, T. Inoue, and K. Shiba (2007)
Nucleic Acids Res. 35, 6357-6366
   Abstract »    Full Text »    PDF »
A Novel Interaction between Atrophin-interacting Protein 4 and beta-p21-activated Kinase-interactive Exchange Factor Is Mediated by an SH3 Domain.
J. M. Janz, T. P. Sakmar, and K. C. Min (2007)
J. Biol. Chem. 282, 28893-28903
   Abstract »    Full Text »    PDF »
Nck{beta} Adapter Controls Neuritogenesis by Maintaining the Cellular Paxillin Level.
S. Guan, M. Chen, D. Woodley, and W. Li (2007)
Mol. Cell. Biol. 27, 6001-6011
   Abstract »    Full Text »    PDF »
Structure and Function of the PB1 Domain, a Protein Interaction Module Conserved in Animals, Fungi, Amoebas, and Plants.
H. Sumimoto, S. Kamakura, and T. Ito (2007)
Sci. STKE 2007, re6
   Abstract »    Full Text »    PDF »
On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
J. D. Faraldo-Gomez and B. Roux (2007)
PNAS 104, 13643-13648
   Abstract »    Full Text »    PDF »
PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome.
M. A. Stiffler, J. R. Chen, V. P. Grantcharova, Y. Lei, D. Fuchs, J. E. Allen, L. A. Zaslavskaia, and G. MacBeath (2007)
Science 317, 364-369
   Abstract »    Full Text »    PDF »
Combinatorial ShcA Docking Interactions Support Diversity in Tissue Morphogenesis.
W. R. Hardy, L. Li, Z. Wang, J. Sedy, J. Fawcett, E. Frank, J. Kucera, and T. Pawson (2007)
Science 317, 251-256
   Abstract »    Full Text »    PDF »
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.
M. Borg, T. Mittag, T. Pawson, M. Tyers, J. D. Forman-Kay, and H. S. Chan (2007)
PNAS 104, 9650-9655
   Abstract »    Full Text »    PDF »
Differential ErbB1 Signaling in Squamous Cell versus Basal Cell Carcinoma of the Skin.
L. Rittie, S. Kansra, S. W. Stoll, Y. Li, J. E. Gudjonsson, Y. Shao, L. E. Michael, G. J. Fisher, T. M. Johnson, and J. T. Elder (2007)
Am. J. Pathol. 170, 2089-2099
   Abstract »    Full Text »    PDF »
Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling.
M. Nizzari, V. Venezia, E. Repetto, V. Caorsi, R. Magrassi, M. C. Gagliani, P. Carlo, T. Florio, G. Schettini, C. Tacchetti, et al. (2007)
J. Biol. Chem. 282, 13833-13844
   Abstract »    Full Text »    PDF »
Functional nonsynonymous single nucleotide polymorphisms from the TGF-{beta} protein interaction network.
S. Savas, I. W. Taylor, J. L. Wrana, and H. Ozcelik (2007)
Physiol Genomics 29, 109-117
   Abstract »    Full Text »    PDF »
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
A. Wolf-Yadlin, S. Hautaniemi, D. A. Lauffenburger, and F. M. White (2007)
PNAS 104, 5860-5865
   Abstract »    Full Text »    PDF »
NHERF1/EBP50 Head-to-Tail Intramolecular Interaction Masks Association with PDZ Domain Ligands.
F. C. Morales, Y. Takahashi, S. Momin, H. Adams, X. Chen, and M.-M. Georgescu (2007)
Mol. Cell. Biol. 27, 2527-2537
   Abstract »    Full Text »    PDF »
Src Docks to A-kinase Anchoring Protein Gravin, Regulating beta2-Adrenergic Receptor Resensitization and Recycling.
J. Tao, H.-y. Wang, and C. C. Malbon (2007)
J. Biol. Chem. 282, 6597-6608
   Abstract »    Full Text »    PDF »
A Network Analysis of Changes in Molecular Interactions in Cellular Signaling.
O. Stoevesandt, K. Kohler, S. Wolf, T. Andre, W. Hummel, and R. Brock (2007)
Mol. Cell. Proteomics 6, 503-513
   Abstract »    Full Text »    PDF »
DOMINO: a database of domain-peptide interactions.
A. Ceol, A. Chatr-aryamontri, E. Santonico, R. Sacco, L. Castagnoli, and G. Cesareni (2007)
Nucleic Acids Res. 35, D557-D560
   Abstract »    Full Text »    PDF »
A Novel Cdc42-interacting Domain of the Yeast Polarity Establishment Protein Bem1: IMPLICATIONS FOR MODULATION OF MATING PHEROMONE SIGNALING.
Y. Yamaguchi, K. Ota, and T. Ito (2007)
J. Biol. Chem. 282, 29-38
   Abstract »    Full Text »    PDF »
Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation.
A. Bracale, F. Cesca, V. E. Neubrand, T. P. Newsome, M. Way, and G. Schiavo (2007)
Mol. Biol. Cell 18, 142-152
   Abstract »    Full Text »    PDF »
Intracellular protein interaction mapping with FRET hybrids.
X. You, A. W. Nguyen, A. Jabaiah, M. A. Sheff, K. S. Thorn, and P. S. Daugherty (2006)
PNAS 103, 18458-18463
   Abstract »    Full Text »    PDF »
Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPXY Peptide Arrays.
M. J. Smith, W. R. Hardy, J. M. Murphy, N. Jones, and T. Pawson (2006)
Mol. Cell. Biol. 26, 8461-8474
   Abstract »    Full Text »    PDF »
Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling.
N. P. Martin, R. P. Mohney, S. Dunn, M. Das, E. Scappini, and J. P. O'Bryan (2006)
Mol. Pharmacol. 70, 1643-1653
   Abstract »    Full Text »    PDF »
Dynamic Profiling of the Post-translational Modifications and Interaction Partners of Epidermal Growth Factor Receptor Signaling after Stimulation by Epidermal Growth Factor Using Extended Range Proteomic Analysis (ERPA).
S.-L. Wu, J. Kim, R. W. Bandle, L. Liotta, E. Petricoin, and B. L. Karger (2006)
Mol. Cell. Proteomics 5, 1610-1627
   Abstract »    Full Text »    PDF »
A High Efficiency Strategy for Binding Property Characterization of Peptide-binding Domains.
E. Song, S. Gao, R. Tian, S. Ma, H. Huang, J. Guo, Y. Li, L. Zhang, and Y. Gao (2006)
Mol. Cell. Proteomics 5, 1368-1381
   Abstract »    Full Text »    PDF »
RACK1 mediates multiple hormone responsiveness and developmental processes in Arabidopsis.
J.-G. Chen, H. Ullah, B. Temple, J. Liang, J. Guo, J. M. Alonso, J. R. Ecker, and A. M. Jones (2006)
J. Exp. Bot. 57, 2697-2708
   Abstract »    Full Text »    PDF »
Zinc Finger Protein Wiz Links G9a/GLP Histone Methyltransferases to the Co-repressor Molecule CtBP.
J. Ueda, M. Tachibana, T. Ikura, and Y. Shinkai (2006)
J. Biol. Chem. 281, 20120-20128
   Abstract »    Full Text »    PDF »
Rules for Modeling Signal-Transduction Systems.
W. S. Hlavacek, J. R. Faeder, M. L. Blinov, R. G. Posner, M. Hucka, and W. Fontana (2006)
Sci. STKE 2006, re6
   Abstract »    Full Text »    PDF »
An Integrated Machine Learning System to Computationally Screen Protein Databases for Protein Binding Peptide Ligands.
L. Zhang, C. Shao, D. Zheng, and Y. Gao (2006)
Mol. Cell. Proteomics 5, 1224-1232
   Abstract »    Full Text »    PDF »
Differential Interactions between Transforming Growth Factor-beta3/TbetaR1, TAB1, and CD2AP Disrupt Blood-Testis Barrier and Sertoli-Germ Cell Adhesion.
W. Xia, D. D. Mruk, W. M. Lee, and C. Y. Cheng (2006)
J. Biol. Chem. 281, 16799-16813
   Abstract »    Full Text »    PDF »
Signaling During Pathogen Infection.
S. Munter, M. Way, and F. Frischknecht (2006)
Sci. STKE 2006, re5
   Abstract »    Full Text »    PDF »
The Multiple Personalities of the Chemokine Receptor CCR7 in Dendritic Cells.
N. Sanchez-Sanchez, L. Riol-Blanco, and J. L. Rodriguez-Fernandez (2006)
J. Immunol. 176, 5153-5159
   Abstract »    Full Text »    PDF »
The DIMA web resource--exploring the protein domain network.
P. Pagel, M. Oesterheld, V. Stumpflen, and D. Frishman (2006)
Bioinformatics 22, 997-998
   Abstract »    Full Text »    PDF »
Interaction of SH2-B{beta} with RET is involved in signaling of GDNF-induced neurite outgrowth.
Y. Zhang, W. Zhu, Y.-G. Wang, X.-J. Liu, L. Jiao, X. Liu, Z.-H. Zhang, C.-L. Lu, and C. He (2006)
J. Cell Sci. 119, 1666-1676
   Abstract »    Full Text »    PDF »
Organizing Motility: LIM Domains, LPP, and Smooth Muscle Migration.
M. W. Majesky (2006)
Circ. Res. 98, 306-308
   Full Text »    PDF »
Building Signaling Complexes at the Membrane.
W. Cho (2006)
Sci. STKE 2006, pe7
   Abstract »    Full Text »    PDF »
BioGRID: a general repository for interaction datasets.
C. Stark, B.-J. Breitkreutz, T. Reguly, L. Boucher, A. Breitkreutz, and M. Tyers (2006)
Nucleic Acids Res. 34, D535-D539
   Abstract »    Full Text »    PDF »
Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors..
I. K. Mellinghoff, M. Y. Wang, I. Vivanco, D. A. Haas-Kogan, S. Zhu, E. Q. Dia, K. V. Lu, K. Yoshimoto, J. H.Y. Huang, D. J. Chute, et al. (2005)
N. Engl. J. Med. 353, 2012-2024
   Abstract »    Full Text »    PDF »
Stable Isotope Labeling of Arabidopsis thaliana Cells and Quantitative Proteomics by Mass Spectrometry.
A. Gruhler, W. X. Schulze, R. Matthiesen, M. Mann, and O. N. Jensen (2005)
Mol. Cell. Proteomics 4, 1697-1709
   Abstract »    Full Text »    PDF »
Ventilator-induced Lung Injury: Role of Protein-Protein Interaction in Mechanosensation.
B. Han, M. Lodyga, and M. Liu (2005)
Proceedings of the ATS 2, 181-187
   Abstract »    Full Text »    PDF »
A Single PDZ Domain Protein Interacts with the Menkes Copper ATPase, ATP7A: A NEW PROTEIN IMPLICATED IN COPPER HOMEOSTASIS.
S. E. M. Stephenson, D. Dubach, C. M. Lim, J. F. B. Mercer, and S. La Fontaine (2005)
J. Biol. Chem. 280, 33270-33279
   Abstract »    Full Text »    PDF »
MONaKA, a Novel Modulator of the Plasma Membrane Na,K-ATPase.
H. Mao, T. S. Ferguson, S. M. Cibulsky, M. Holmqvist, C. Ding, H. Fei, and I. B. Levitan (2005)
J. Neurosci. 25, 7934-7943
   Abstract »    Full Text »    PDF »
WW Domains Provide a Platform for the Assembly of Multiprotein Networks.
R. J. Ingham, K. Colwill, C. Howard, S. Dettwiler, C. S. H. Lim, J. Yu, K. Hersi, J. Raaijmakers, G. Gish, G. Mbamalu, et al. (2005)
Mol. Cell. Biol. 25, 7092-7106
   Abstract »    Full Text »    PDF »
14-3-3 Proteins: A Number of Functions for a Numbered Protein.
D. Bridges and G. B. G. Moorhead (2005)
Sci. STKE 2005, re10
   Abstract »    Full Text »    PDF »
A-kinase-anchoring proteins.
L. K. Langeberg and J. D. Scott (2005)
J. Cell Sci. 118, 3217-3220
   Full Text »    PDF »
Molecular Dissection of PINCH-1 Reveals a Mechanism of Coupling and Uncoupling of Cell Shape Modulation and Survival.
Z. Xu, T. Fukuda, Y. Li, X. Zha, J. Qin, and C. Wu (2005)
J. Biol. Chem. 280, 27631-27637
   Abstract »    Full Text »    PDF »
PRODOC: a resource for the comparison of tethered protein domain architectures with in-built information on remotely related domain families.
O. Krishnadev, N. Rekha, S. B. Pandit, S. Abhiman, S. Mohanty, L. S. Swapna, S. Gore, and N. Srinivasan (2005)
Nucleic Acids Res. 33, W126-W129
   Abstract »    Full Text »    PDF »
A Peptide Triggers Allostery in Tet Repressor by Binding to a Unique Site.
M. Klotzsche, C. Berens, and W. Hillen (2005)
J. Biol. Chem. 280, 24591-24599
   Abstract »    Full Text »    PDF »
Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation.
I. Kratchmarova, B. Blagoev, M. Haack-Sorensen, M. Kassem, and M. Mann (2005)
Science 308, 1472-1477
   Abstract »    Full Text »    PDF »
The Many Faces of SAM.
F. Qiao and J. U. Bowie (2005)
Sci. STKE 2005, re7
   Abstract »    Full Text »    PDF »
Chemical Theory and Computation Special Feature: Molecular dynamics and protein function.
M. Karplus and J. Kuriyan (2005)
PNAS 102, 6679-6685
   Abstract »    Full Text »    PDF »
Chemical Theory and Computation Special Feature: Calculation of absolute protein-ligand binding free energy from computer simulations.
H.-J. Woo and B. Roux (2005)
PNAS 102, 6825-6830
   Abstract »    Full Text »    PDF »
A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.
W. Feng, J.-f. Long, and M. Zhang (2005)
PNAS 102, 6861-6866
   Abstract »    Full Text »    PDF »
Increased SH2-B{beta} content and membrane association in transgenic mice overexpressing GH.
J G Miquet, A I Sotelo, A Bartke, and D Turyn (2005)
J. Endocrinol. 185, 301-306
   Abstract »    Full Text »    PDF »
Force sensing and generation in cell phases: analyses of complex functions.
H.-G. Dobereiner, B. J. Dubin-Thaler, G. Giannone, and M. P. Sheetz (2005)
J Appl Physiol 98, 1542-1546
   Abstract »    Full Text »    PDF »
Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells.
A. Thelemann, F. Petti, G. Griffin, K. Iwata, T. Hunt, T. Settinari, D. Fenyo, N. Gibson, and J. D. Haley (2005)
Mol. Cell. Proteomics 4, 356-376
   Abstract »    Full Text »    PDF »
Statistical analysis of domains in interacting protein pairs.
T. M. W. Nye, C. Berzuini, W. R. Gilks, M. M. Babu, and S. A. Teichmann (2005)
Bioinformatics 21, 993-1001
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)