Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Invitrogen

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 April 2003:
Vol. 300. no. 5616, pp. 91 - 96
DOI: 10.1126/science.1082177
Prev | Table of Contents | Next

Review

Mitosis Through the Microscope: Advances in Seeing Inside Live Dividing Cells

Conly L. Rieder,* Alexey Khodjakov*

The most visually spectacular events in the life of a cell occur when it divides. This is especially true in higher eukaryotes, where the size and geometry of cells allow the division process to be followed through a microscope with considerable clarity. In these organisms, the membrane surrounding the nucleus breaks down after the replicated DNA has condensed to form discrete chromosomes. Several new structures are then assembled to separate the chromosomes and partition the cytoplasm into two separate cells.

Lab of Cell Regulation, Division of Molecular Medicine, Wadsworth Center, Albany, NY 12201-0509, USA. Department of Biomedical Sciences, State University of New York, Albany, NY 12222, USA. Marine Biology Laboratory, Woods Hole, MA 02543, USA.
*   To whom correspondence should be addressed. Molecular Medicine, Wadsworth Center, Post Office Box 509, Albany, NY 12201-0509, USA. E-mail: rieder{at}wadsworth.org, khodj{at}wadsworth.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genes Required for Mitotic Spindle Assembly in Drosophila S2 Cells.
G. Goshima, R. Wollman, S. S. Goodwin, N. Zhang, J. M. Scholey, R. D. Vale, and N. Stuurman (2007)
Science 316, 417-421
   Abstract »    Full Text »    PDF »
Mucin Granule Intraluminal Organization.
J. Perez-Vilar (2007)
Am. J. Respir. Cell Mol. Biol. 36, 183-190
   Abstract »    Full Text »    PDF »
Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay.
P. S. Maddox, N. Portier, A. Desai, and K. Oegema (2006)
PNAS 103, 15097-15102
   Abstract »    Full Text »    PDF »
Contribution of microtubule growth polarity and flux to spindle assembly and functioning in plant cells..
P. Dhonukshe, N. Vischer, and T. W. J. Gadella Jr (2006)
J. Cell Sci. 119, 3193-3205
   Abstract »    Full Text »    PDF »
Using Long-term Time-lapse Imaging of Mammalian Cell Cycle Progression for Laboratory Instruction and Analysis.
E. H. Hinchcliffe (2005)
CBE Life Sci Educ 4, 284-290
   Full Text »    PDF »
Silencing Mitosin Induces Misaligned Chromosomes, Premature Chromosome Decondensation before Anaphase Onset, and Mitotic Cell Death.
Z. Yang, J. Guo, Q. Chen, C. Ding, J. Du, and X. Zhu (2005)
Mol. Cell. Biol. 25, 4062-4074
   Abstract »    Full Text »    PDF »
Video Views and Reviews: Cytokinesis: A Phenomenon Overlooked Too Often.
C. Watters (2005)
CBE Life Sci Educ 4, 10-18
   Full Text »    PDF »
Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase.
N. M. Rusan and P. Wadsworth (2005)
J. Cell Biol. 168, 21-28
   Abstract »    Full Text »    PDF »
Intracellular Hyaluronan in Arterial Smooth Muscle Cells: Association with Microtubules, RHAMM, and the Mitotic Spindle.
S. P. Evanko, W. T. Parks, and T. N. Wight (2004)
J. Histochem. Cytochem. 52, 1525-1536
   Abstract »    Full Text »    PDF »
Microtubule Plus-End Dynamics in Xenopus Egg Extract Spindles.
J. S. Tirnauer, E. D. Salmon, and T. J. Mitchison (2004)
Mol. Biol. Cell 15, 1776-1784
   Abstract »    Full Text »    PDF »
Light Microscopy Techniques for Live Cell Imaging.
D. J. Stephens and V. J. Allan (2003)
Science 300, 82-86
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)