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Science 28 March 2003:
Vol. 299. no. 5615, pp. 2074 - 2076
DOI: 10.1126/science.1080029
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Reports

A Genomic View of the Human-Bacteroides thetaiotaomicron Symbiosis

Jian Xu, Magnus K. Bjursell, Jason Himrod, Su Deng, Lynn K. Carmichael, Herbert C. Chiang, Lora V. Hooper, Jeffrey I. Gordon*

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
*   To whom correspondence should be addressed. E-mail: jgordon{at}molecool.wustl.edu

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   Abstract »    Full Text »    PDF »
Comparative Whole-Genome Analysis of Virulent and Avirulent Strains of Porphyromonas gingivalis.
T. Chen, Y. Hosogi, K. Nishikawa, K. Abbey, R. D. Fleischmann, J. Walling, and M. J. Duncan (2004)
J. Bacteriol. 186, 5473-5479
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of Bifidobacterium bifidum 1,2-{alpha}-L-Fucosidase (AfcA), a Novel Inverting Glycosidase (Glycoside Hydrolase Family 95).
T. Katayama, A. Sakuma, T. Kimura, Y. Makimura, J. Hiratake, K. Sakata, T. Yamanoi, H. Kumagai, and K. Yamamoto (2004)
J. Bacteriol. 186, 4885-4893
   Abstract »    Full Text »    PDF »
Specific PCR Assay for a Tannin-Tolerant Selenomonas ruminantium Isolate, Derived from Helicase Coding Sequences.
R. Bishop, M. Obura, D. Odongo, and A. Odenyo (2004)
Appl. Envir. Microbiol. 70, 3180-3182
   Abstract »    Full Text »    PDF »
The Three-dimensional Structure of Invertase ({beta}-Fructosidase) from Thermotoga maritima Reveals a Bimodular Arrangement and an Evolutionary Relationship between Retaining and Inverting Glycosidases.
F. Alberto, C. Bignon, G. Sulzenbacher, B. Henrissat, and M. Czjzek (2004)
J. Biol. Chem. 279, 18903-18910
   Abstract »    Full Text »    PDF »
Identification of Bacteroides thetaiotaomicron on the Basis of an Unexpected Specific Amplicon of Universal 16S Ribosomal DNA PCR.
L.-J. Teng, P.-R. Hsueh, Y.-H. Huang, and J.-C. Tsai (2004)
J. Clin. Microbiol. 42, 1727-1730
   Abstract »    Full Text »    PDF »
Evolution of genomic islands by deletion and tandem accretion by site-specific recombination: ICESt1-related elements from Streptococcus thermophilus.
G. Pavlovic, V. Burrus, B. Gintz, B. Decaris, and G. Guedon (2004)
Microbiology 150, 759-774
   Abstract »    Full Text »    PDF »
From The Cover: Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota.
J. F. Rawls, B. S. Samuel, and J. I. Gordon (2004)
PNAS 101, 4596-4601
   Abstract »    Full Text »    PDF »
The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.
R. D. Pridmore, B. Berger, F. Desiere, D. Vilanova, C. Barretto, A.-C. Pittet, M.-C. Zwahlen, M. Rouvet, E. Altermann, R. Barrangou, et al. (2004)
PNAS 101, 2512-2517
   Abstract »    Full Text »    PDF »
Colonic Bacterial Flora: Changing Understandings in the Molecular Age.
V. Mai and J. G. Morris Jr. (2004)
J. Nutr. 134, 459-464
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Flavobacterium johnsoniae GldH Is a Lipoprotein That Is Required for Gliding Motility and Chitin Utilization.
M. J. McBride, T. F. Braun, and J. L. Brust (2003)
J. Bacteriol. 185, 6648-6657
   Abstract »    Full Text »    PDF »
A New Bacteroides Conjugative Transposon That Carries an ermB Gene.
A. Gupta, H. Vlamakis, N. Shoemaker, and A. A. Salyers (2003)
Appl. Envir. Microbiol. 69, 6455-6463
   Abstract »    Full Text »    PDF »
Diversity and Abundance of Uncultured Cytophaga-Like Bacteria in the Delaware Estuary.
D. L. Kirchman, L. Yu, and M. T. Cottrell (2003)
Appl. Envir. Microbiol. 69, 6587-6596
   Abstract »    Full Text »    PDF »


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