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Science 14 March 2003:
Vol. 299. no. 5613, pp. 1753 - 1755
DOI: 10.1126/science.1080902
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Reports

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

Hengmi Cui,1* Marcia Cruz-Correa,1* Francis M. Giardiello,12 David F. Hutcheon,1 David R. Kafonek,1 Sheri Brandenburg,1 Yiqian Wu,1 Xiaobing He,1 Neil R. Powe,14 Andrew P. Feinberg123dagger

Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. In a pilot study to investigate the utility of LOI as a marker of CRC risk, we evaluated 172 patients at a colonoscopy clinic. The adjusted odds ratio for LOI in lymphocytes was 5.15 for patients with a positive family history [95% confidence interval (95% CI), 1.70 to 16.96; probability P = 0.002], 3.46 for patients with adenomas (95% CI, 1.14 to 11.37; P = 0.026), and 21.7 for patients with CRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed with a DNA-based blood test, and it may be a valuable predictive marker of an individual's risk for CRC.

1 Department of Medicine,
2 Department of Oncology,
3 Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 1064 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
4 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: afeinberg{at}jhu.edu

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