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Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk
Hengmi Cui,1*Marcia Cruz-Correa,1*Francis M. Giardiello,12David F. Hutcheon,1David R. Kafonek,1Sheri Brandenburg,1Yiqian Wu,1Xiaobing He,1Neil R. Powe,14Andrew P. Feinberg123
Loss of imprinting (LOI), an epigenetic alteration
affecting the insulin-like growth factor II gene (IGF2), is
found in normalcolonic mucosa of about 30% of colorectal cancer (CRC)
patients,but it is found in only 10% of healthy individuals. In a
pilotstudy to investigate the utility of LOI as a marker of CRC risk,we evaluated 172 patients at a colonoscopy clinic. The adjustedodds
ratio for LOI in lymphocytes was 5.15 for patients with apositive
family history [95% confidence interval (95% CI), 1.70to 16.96;
probability P = 0.002], 3.46 for patients with
adenomas(95% CI, 1.14 to 11.37; P = 0.026), and 21.7 for patients withCRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed witha DNA-based blood test, and it may be
a valuable predictive markerof an individual's risk for CRC.
1 Department of Medicine,
2 Department of Oncology,
3 Department of Molecular Biology and Genetics,
Johns Hopkins University School of Medicine, 1064 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
4 Department of Epidemiology, Johns Hopkins
Bloomberg School of Public Health, Baltimore, MD 21205, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
afeinberg{at}jhu.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
David F. Ransohoff (14 March 2003) Science299 (5613), 1679.
[DOI: 10.1126/science.1083158] |Summary »|Full Text »|PDF »
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