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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1355 - 1359
DOI: 10.1126/science.1079161
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Review

Aging and Genome Maintenance: Lessons from the Mouse?

Paul Hasty,1* Judith Campisi,34 Jan Hoeijmakers,5 Harry van Steeg,6 Jan Vijg27*

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

1 Department of Molecular Medicine,
2 Department of Physiology and Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA.
3 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
4 Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
5 MGC-Department of Cell Biology and Genetics, CBG, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands.
6 National Institute of Public Health and the Environment, Post Office Box 1, 3720 BA Bilthoven, Netherlands.
7 Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
*   To whom correspondence should be addressed. E-mail: hastye{at}uthscsa.edu, vijg{at}uthscsa.edu

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