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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1346 - 1351
DOI: 10.1126/science.1081447
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Review

The Endocrine Regulation of Aging by Insulin-like Signals

Marc Tatar,1 Andrzej Bartke,2 Adam Antebi3

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but with inevitable increases in stress resistance. Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.

1 Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
2 Department of Medicine, Southern Illinois University, Springfield, IL 62794, USA.
3 Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

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