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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1346 - 1351
DOI: 10.1126/science.1081447
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Review

The Endocrine Regulation of Aging by Insulin-like Signals

Marc Tatar,1 Andrzej Bartke,2 Adam Antebi3

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but with inevitable increases in stress resistance. Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.

1 Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
2 Department of Medicine, Southern Illinois University, Springfield, IL 62794, USA.
3 Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
H. J. Goren, R. N. Kulkarni, and C. R. Kahn (2004)
Endocrinology 145, 3307-3323
   Abstract »    Full Text »    PDF »
Inside Insulin Signaling, Communication Is Key to Long Life.
A. Antebi (2004)
Sci. Aging Knowl. Environ. 2004, pe25
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Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.
G. N. Landis, D. Abdueva, D. Skvortsov, J. Yang, B. E. Rabin, J. Carrick, S. Tavare, and J. Tower (2004)
PNAS 101, 7663-7668
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THE HUNT FOR THE RECORD LIFE SPAN IN CAENORHABDITIS ELEGANS.
K. Houthoofd, B. P. Braeckman, and J. R. Vanfleteren (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B408-B410
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Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues.
B. Gerisch and A. Antebi (2004)
Development 131, 1765-1776
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Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.
M. Bauer, A. C. Hamm, M. Bonaus, A. Jacob, J. Jaekel, H. Schorle, M. J. Pankratz, and J. D. Katzenberger (2004)
Physiol Genomics 17, 230-244
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Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster.
T. Magwere, T. Chapman, and L. Partridge (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B3-9
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Negative energy balance plays a major role in the IGF-I response to exercise training.
D. Nemet, P. H. Connolly, A. M. Pontello-Pescatello, C. Rose-Gottron, J. K. Larson, P. Galassetti, and D. M. Cooper (2004)
J Appl Physiol 96, 276-282
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Convergence of Peroxisome Proliferator-activated Receptor {gamma} and Foxo1 Signaling Pathways.
P. Dowell, T. C. Otto, S. Adi, and M. D. Lane (2003)
J. Biol. Chem. 278, 45485-45491
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A Reduction in Intestinal Cell pHi Due to Loss of the Caenorhabditis elegans Na+/H+ Exchanger NHX-2 Increases Life Span.
K. Nehrke (2003)
J. Biol. Chem. 278, 44657-44666
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