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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1346 - 1351
DOI: 10.1126/science.1081447
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Review

The Endocrine Regulation of Aging by Insulin-like Signals

Marc Tatar,1 Andrzej Bartke,2 Adam Antebi3

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but with inevitable increases in stress resistance. Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.

1 Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
2 Department of Medicine, Southern Illinois University, Springfield, IL 62794, USA.
3 Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

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Sci. Aging Knowl. Environ. 2004, pe32
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Divergent Effects of Caloric Restriction on Gene Expression in Normal and Long-Lived Mice.
M. M. Masternak, K. Al-Regaiey, M. S. Bonkowski, J. Panici, L. Sun, J. Wang, G. K. Przybylski, and A. Bartke (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B784-B788
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From the Cover: Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl.
D. W. Walker and S. Benzer (2004)
PNAS 101, 10290-10295
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Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
H. J. Goren, R. N. Kulkarni, and C. R. Kahn (2004)
Endocrinology 145, 3307-3323
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Inside Insulin Signaling, Communication Is Key to Long Life.
A. Antebi (2004)
Sci. Aging Knowl. Environ. 2004, pe25
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Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.
G. N. Landis, D. Abdueva, D. Skvortsov, J. Yang, B. E. Rabin, J. Carrick, S. Tavare, and J. Tower (2004)
PNAS 101, 7663-7668
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THE HUNT FOR THE RECORD LIFE SPAN IN CAENORHABDITIS ELEGANS.
K. Houthoofd, B. P. Braeckman, and J. R. Vanfleteren (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B408-B410
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