Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 February 2003:
Vol. 299. no. 5610, pp. 1237 - 1240
DOI: 10.1126/science.1080659
Prev | Table of Contents | Next

Reports

Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia

Hiroshi Ikeda,12* Bernhard Heinke,12 Ruth Ruscheweyh,12 Jürgen Sandkühler12dagger

Inflammation, trauma, or nerve injury may cause enduring hyperalgesia, an enhanced sensitivity to painful stimuli. Neurons in lamina I of the spinal dorsal horn that express the neurokinin 1 receptor for substance P mediate this abnormal pain sensitivity by an unknown cellular mechanism. We report that in these, but not in other nociceptive lamina I cells, neurokinin 1 receptor-activated signal transduction pathways and activation of low-threshold (T-type) voltage-gated calcium channels synergistically facilitate activity- and calcium-dependent long-term potentiation at synapses from nociceptive nerve fibers. Thereby, memory traces of painful events are retained.

1 Institute of Physiology and Pathophysiology, Heidelberg University, D-69120 Heidelberg, Germany.
2 Brain Research Institute, Vienna University Medical School, A-1090 Vienna, Austria.
*   Present address: Department of Human and Artificial Intelligence Systems, Fukui University, Fukui, Japan.

dagger    To whom correspondence should be addressed. E-mail: juergen.sandkuehler{at}univie.ac.at

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal.
R. Drdla, M. Gassner, E. Gingl, and J. Sandkuhler (2009)
Science 325, 207-210
   Abstract »    Full Text »    PDF »
Sensitization of lamina I spinoparabrachial neurons parallels heat hyperalgesia in the chronic constriction injury model of neuropathic pain.
D. Andrew (2009)
J. Physiol. 587, 2005-2017
   Abstract »    Full Text »    PDF »
Models and Mechanisms of Hyperalgesia and Allodynia.
J. Sandkuhler (2009)
Physiol Rev 89, 707-758
   Abstract »    Full Text »    PDF »
Differential endogenous pain modulation in complex-regional pain syndrome.
F. Seifert, G. Kiefer, R. DeCol, M. Schmelz, and C. Maihofner (2009)
Brain 132, 788-800
   Abstract »    Full Text »    PDF »
Mechanisms and Functional Significance of Inhibition of Neuronal T-Type Calcium Channels by Isoflurane.
P. Orestes, D. Bojadzic, R. M. Chow, and S. M. Todorovic (2009)
Mol. Pharmacol. 75, 542-554
   Abstract »    Full Text »    PDF »
Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex.
H. Xu, L.-J. Wu, H. Wang, X. Zhang, K. I. Vadakkan, S. S. Kim, H. W. Steenland, and M. Zhuo (2008)
J. Neurosci. 28, 7445-7453
   Abstract »    Full Text »    PDF »
Translocation of GluR1-Containing AMPA Receptors to a Spinal Nociceptive Synapse during Acute Noxious Stimulation.
M. Larsson and J. Broman (2008)
J. Neurosci. 28, 7084-7090
   Abstract »    Full Text »    PDF »
Neuropathic pain: emerging treatments.
A. Dray (2008)
Br. J. Anaesth. 101, 48-58
   Abstract »    Full Text »    PDF »
Developmental Changes in the Fidelity and Short-Term Plasticity of GABAergic Synapses in the Neonatal Rat Dorsal Horn.
R. A. Ingram, M. Fitzgerald, and M. L. Baccei (2008)
J Neurophysiol 99, 3144-3150
   Abstract »    Full Text »    PDF »
Recording Temperature Affects the Excitability of Mouse Superficial Dorsal Horn Neurons, In Vitro.
B. A. Graham, A. M. Brichta, and R. J. Callister (2008)
J Neurophysiol 99, 2048-2059
   Abstract »    Full Text »    PDF »
Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat.
K. S. Vikman, B. K. Rycroft, and M. J. Christie (2008)
J. Physiol. 586, 515-527
   Abstract »    Full Text »    PDF »
A Role for Transcriptional Repressor Methyl-CpG-Binding Protein 2 and Plasticity-Related Gene Serum- and Glucocorticoid-Inducible Kinase 1 in the Induction of Inflammatory Pain States.
S. M. Geranton, C. Morenilla-Palao, and S. P. Hunt (2007)
J. Neurosci. 27, 6163-6173
   Abstract »    Full Text »    PDF »
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn.
B. K. Rycroft, K. S. Vikman, and M. J. Christie (2007)
J. Physiol. 580, 883-894
   Abstract »    Full Text »    PDF »
Psychophysical Evidence for Long-Term Potentiation of C-Fiber and A{delta}-Fiber Pathways in Humans by Analysis of Pain Descriptors.
N. Hansen, T. Klein, W. Magerl, and R.-D. Treede (2007)
J Neurophysiol 97, 2559-2563
   Abstract »    Full Text »    PDF »
Perceptual Correlate of Nociceptive Long-Term Potentiation (LTP) in Humans Shares the Time Course of Early-LTP.
T. Klein, W. Magerl, and R.-D. Treede (2006)
J Neurophysiol 96, 3551-3555
   Abstract »    Full Text »    PDF »
Plasticity in the human central nervous system.
S. F. Cooke and T. V. P. Bliss (2006)
Brain 129, 1659-1673
   Abstract »    Full Text »    PDF »
Synaptic amplifier of inflammatory pain in the spinal dorsal horn..
H. Ikeda, J. Stark, H. Fischer, M. Wagner, R. Drdla, T. Jager, and J. Sandkuhler (2006)
Science 312, 1659-1662
   Abstract »    Full Text »    PDF »
Pathway-specific bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II at spinal nociceptive synapses after acute noxious stimulation..
M. Larsson and J. Broman (2006)
J. Neurosci. 26, 4198-4205
   Abstract »    Full Text »    PDF »
T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates.
M. Uebachs, C. Schaub, E. Perez-Reyes, and H. Beck (2006)
J. Physiol. 571, 519-536
   Abstract »    Full Text »    PDF »
Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to Activation of Extracellular Signal-Regulated Kinase in Spinal Dorsal Horn Neurons in Adult Rats and Mice.
F. Wei, K. I. Vadakkan, H. Toyoda, L.-J. Wu, M.-G. Zhao, H. Xu, F. W.F. Shum, Y. H. Jia, and M. Zhuo (2006)
J. Neurosci. 26, 851-861
   Abstract »    Full Text »    PDF »
Substance P, Neurokinins A and B, and Synthetic Tachykinin Peptides Protect Mesencephalic Dopaminergic Neurons in Culture via an Activity-Dependent Mechanism.
B. Salthun-Lassalle, S. Traver, E. C. Hirsch, and P. P. Michel (2005)
Mol. Pharmacol. 68, 1214-1224
   Abstract »    Full Text »    PDF »
Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity.
M. Cordero-Erausquin, J. A. M. Coull, D. Boudreau, M. Rolland, and Y. D. Koninck (2005)
J. Neurosci. 25, 9613-9623
   Abstract »    Full Text »    PDF »
Low dose of S(+)-ketamine prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo.
J. Benrath, C. Brechtel, J. Stark, and J. Sandkuhler (2005)
Br. J. Anaesth. 95, 518-523
   Abstract »    Full Text »    PDF »
Activation of Spinal D1/D5 Receptors Induces Late-Phase LTP of C-Fiber-Evoked Field Potentials in Rat Spinal Dorsal Horn.
H.-W. Yang, L.-J. Zhou, N.-W. Hu, W.-J. Xin, and X.-G. Liu (2005)
J Neurophysiol 94, 961-967
   Abstract »    Full Text »    PDF »
Synaptic input of rat spinal lamina I projection and unidentified neurones in vitro.
A. Dahlhaus, R. Ruscheweyh, and J. Sandkuhler (2005)
J. Physiol. 566, 355-368
   Abstract »    Full Text »    PDF »
Integration Time in a Subset of Spinal Lamina I Neurons Is Lengthened by Sodium and Calcium Currents Acting Synergistically to Prolong Subthreshold Depolarization.
S. A. Prescott and Y. De Koninck (2005)
J. Neurosci. 25, 4743-4754
   Abstract »    Full Text »    PDF »
Modular Organization of Excitatory Circuits between Neurons of the Spinal Superficial Dorsal Horn (Laminae I and II).
Y. Lu and E. R. Perl (2005)
J. Neurosci. 25, 3900-3907
   Abstract »    Full Text »    PDF »
Glial Nitric Oxide-Mediated Long-Term Presynaptic Facilitation Revealed by Optical Imaging in Rat Spinal Dorsal Horn.
H. Ikeda and K. Murase (2004)
J. Neurosci. 24, 9888-9896
   Abstract »    Full Text »    PDF »
Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice.
B. Heinke, R. Ruscheweyh, L. Forsthuber, G. Wunderbaldinger, and J. Sandkuhler (2004)
J. Physiol. 560, 249-266
   Abstract »    Full Text »    PDF »
Presynaptic NMDA Receptors Modulate Glutamate Release from Primary Sensory Neurons in Rat Spinal Cord Dorsal Horn.
R. Bardoni, C. Torsney, C.-K. Tong, M. Prandini, and A. B. MacDermott (2004)
J. Neurosci. 24, 2774-2781
   Abstract »    Full Text »    PDF »
Roles of CaMKII, PKA, and PKC in the Induction and Maintenance of LTP of C-Fiber-Evoked Field Potentials in Rat Spinal Dorsal Horn.
H.-W. Yang, X.-D. Hu, H.-M. Zhang, W.-J. Xin, M.-T. Li, T. Zhang, L.-J. Zhou, and X.-G. Liu (2004)
J Neurophysiol 91, 1122-1133
   Abstract »    Full Text »    PDF »
Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro.
R. Ruscheweyh, H. Ikeda, B. Heinke, and J. Sandkuhler (2004)
J. Physiol. 555, 527-543
   Abstract »    Full Text »    PDF »
Perceptual Correlates of Nociceptive Long-Term Potentiation and Long-Term Depression in Humans.
T. Klein, W. Magerl, H.-C. Hopf, J. Sandkuhler, and R.-D. Treede (2004)
J. Neurosci. 24, 964-971
   Abstract »    Full Text »    PDF »
A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca2+/Calmodulin-Dependent Kinase II.
P. J. Welsby, H. Wang, J. T. Wolfe, R. J. Colbran, M. L. Johnson, and P. Q. Barrett (2003)
J. Neurosci. 23, 10116-10121
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)