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Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Shohei Hori,1Takashi Nomura,2Shimon Sakaguchi12*
Regulatory T cells engage in the maintenance of
immunological self-tolerance by actively suppressing self-reactive
lymphocytes.Little is known, however, about the molecular mechanism of
theirdevelopment. Here we show that Foxp3, which encodes a
transcriptionfactor that is genetically defective in an autoimmune and
inflammatorysyndrome in humans and mice, is specifically expressed in
naturallyarising CD4+ regulatory T cells. Furthermore,
retroviral gene transfer ofFoxp3 converts naïve T
cells toward a regulatory T cell phenotypesimilar to that of naturally
occurring CD4+ regulatory T cells. Thus, Foxp3
is a key regulatory gene forthe development of regulatory T cells.
1 Laboratory of Immunopathology, Research
Center for Allergy and Immunology, Institute for Physical and Chemical
Research, Yokohama 230-0045, Japan.
2 Department of
Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto
University, Kyoto 606-8507, Japan.
*
To whom correspondence should be addressed. E-mail:
shimon{at}frontier.kyoto-u.ac.jp
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A. Andersson, S.-C. Yang, M. Huang, L. Zhu, U. K. Kar, R. K. Batra, D. Elashoff, R. M. Strieter, S. M. Dubinett, and S. Sharma (2009)
J. Immunol.
182, 6951-6958
|Abstract »|Full Text »|PDF »
Oxidized LDL Modulates Apoptosis of Regulatory T Cells in Patients with ESRD.
P. Meier, D. Golshayan, E. Blanc, M. Pascual, and M. Burnier (2009)
J. Am. Soc. Nephrol.
20, 1368-1384
|Abstract »|Full Text »|PDF »
Thymic function in juvenile idiopathic arthritis.
A R Lorenzi, T A Morgan, A Anderson, J Catterall, A M Patterson, H E Foster, and J D Isaacs (2009)
Ann Rheum Dis
68, 983-990
|Abstract »|Full Text »|PDF »
Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis.
