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Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Shohei Hori,1Takashi Nomura,2Shimon Sakaguchi12*
Regulatory T cells engage in the maintenance of
immunological self-tolerance by actively suppressing self-reactive
lymphocytes.Little is known, however, about the molecular mechanism of
theirdevelopment. Here we show that Foxp3, which encodes a
transcriptionfactor that is genetically defective in an autoimmune and
inflammatorysyndrome in humans and mice, is specifically expressed in
naturallyarising CD4+ regulatory T cells. Furthermore,
retroviral gene transfer ofFoxp3 converts naïve T
cells toward a regulatory T cell phenotypesimilar to that of naturally
occurring CD4+ regulatory T cells. Thus, Foxp3
is a key regulatory gene forthe development of regulatory T cells.
1 Laboratory of Immunopathology, Research
Center for Allergy and Immunology, Institute for Physical and Chemical
Research, Yokohama 230-0045, Japan.
2 Department of
Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto
University, Kyoto 606-8507, Japan.
*
To whom correspondence should be addressed. E-mail:
shimon{at}frontier.kyoto-u.ac.jp
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S. Gnjatic, N. K. Altorki, D. N. Tang, S.-M. Tu, V. Kundra, G. Ritter, L. J. Old, C. J. Logothetis, and P. Sharma (2009)
Clin. Cancer Res.
15, 2130-2139
|Abstract »|Full Text »|PDF »
Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches.
M. Tsuji, N. Komatsu, S. Kawamoto, K. Suzuki, O. Kanagawa, T. Honjo, S. Hori, and S. Fagarasan (2009)
Science
323, 1488-1492
|Abstract »|Full Text »|PDF »
