Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 January 2003:
Vol. 299. no. 5606, pp. 572 - 574
DOI: 10.1126/science.1078223
Prev | Table of Contents | Next

Reports

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Matthias Blüher,1 Barbara B. Kahn,2 C. Ronald Kahn1*

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic abnormalities, although their food intake is normal. Both male and female FIRKO mice were found to have an increase in mean life-span of ~134 days (18%), with parallel increases in median and maximum life-spans. Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling.

1 Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA.
2 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215 USA.
*   To whom correspondence should be addressed. E-mail: c.ronald.kahn{at}joslin.harvard.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New Insights Into Cardiac Aging.
A. J. Muslin (2009)
Circulation 120, 1654-1656
   Full Text »    PDF »
Prolonged Exposure to Insulin Suppresses Mitochondrial Production in Primary Hepatocytes.
H.-Y. Liu, E. Yehuda-Shnaidman, T. Hong, J. Han, J. Pi, Z. Liu, and W. Cao (2009)
J. Biol. Chem. 284, 14087-14095
   Abstract »    Full Text »    PDF »
FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes.
P. Chakrabarti and K. V. Kandror (2009)
J. Biol. Chem. 284, 13296-13300
   Abstract »    Full Text »    PDF »
Biological Approaches to Mechanistically Understand the Healthy Life Span Extension Achieved by Calorie Restriction and Modulation of Hormones.
N. Barzilai and A. Bartke (2009)
J Gerontol A Biol Sci Med Sci
   Abstract »    Full Text »    PDF »
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
S. Chen, J. R. Whetstine, S. Ghosh, J. A. Hanover, R. R. Gali, P. Grosu, and Y. Shi (2009)
PNAS 106, 1496-1501
   Abstract »    Full Text »    PDF »
SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPAR{gamma}.
F. Wang and Q. Tong (2009)
Mol. Biol. Cell 20, 801-808
   Abstract »    Full Text »    PDF »
p66Shc-generated Oxidative Signal Promotes Fat Accumulation.
I. Berniakovich, M. Trinei, M. Stendardo, E. Migliaccio, S. Minucci, P. Bernardi, P. G. Pelicci, and M. Giorgio (2008)
J. Biol. Chem. 283, 34283-34293
   Abstract »    Full Text »    PDF »
Increased Vascular Senescence and Impaired Endothelial Progenitor Cell Function Mediated by Mutation of Circadian Gene Per2.
C.-Y. Wang, M.-S. Wen, H.-W. Wang, I-C. Hsieh, Y. Li, P.-Y. Liu, F.-C. Lin, and J. K. Liao (2008)
Circulation 118, 2166-2173
   Abstract »    Full Text »    PDF »
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans.
M. C. Wang, E. J. O'Rourke, and G. Ruvkun (2008)
Science 322, 957-960
   Abstract »    Full Text »    PDF »
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging.
W.-L. Yen and D. J. Klionsky (2008)
Physiology 23, 248-262
   Abstract »    Full Text »    PDF »
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
E. Neumann-Haefelin, W. Qi, E. Finkbeiner, G. Walz, R. Baumeister, and M. Hertweck (2008)
Genes & Dev. 22, 2721-2735
   Abstract »    Full Text »    PDF »
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.
R. A. Butcher, J. R. Ragains, E. Kim, and J. Clardy (2008)
PNAS 105, 14288-14292
   Abstract »    Full Text »    PDF »
FOXO3A genotype is strongly associated with human longevity.
B. J. Willcox, T. A. Donlon, Q. He, R. Chen, J. S. Grove, K. Yano, K. H. Masaki, D. C. Willcox, B. Rodriguez, and J. D. Curb (2008)
PNAS 105, 13987-13992
   Abstract »    Full Text »    PDF »
Insulin/Insulin-Like Growth Factor-1 Signaling and Cognitive Function in Humans.
S. M. Euser, D. van Heemst, P. van Vliet, M. M. B. Breteler, and R. G. J. Westendorp (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 907-910
   Abstract »    Full Text »    PDF »
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype.
C. A Conover, M. A Mason, J. A Levine, and C. M Novak (2008)
J. Endocrinol. 198, 599-605
   Abstract »    Full Text »    PDF »
Evidence that the gene encoding insulin degrading enzyme influences human lifespan.
M.-G. Hong, C. Reynolds, M. Gatz, B. Johansson, J. C. Palmer, H. F. Gu, K. Blennow, P. G. Kehoe, U. de Faire, N. L. Pedersen, et al. (2008)
Hum. Mol. Genet. 17, 2370-2378
   Abstract »    Full Text »    PDF »
Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth.
N. Kloting, L. Koch, T. Wunderlich, M. Kern, K. Ruschke, W. Krone, J. C. Bruning, and M. Bluher (2008)
Diabetes 57, 2074-2082
   Abstract »    Full Text »    PDF »
Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways.
J.-Y. Deng, P.-S. Hsieh, J.-P. Huang, L.-S. Lu, and L.-M. Hung (2008)
Diabetes 57, 1814-1823
   Abstract »    Full Text »    PDF »
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
C. Selman, S. Lingard, A. I. Choudhury, R. L. Batterham, M. Claret, M. Clements, F. Ramadani, K. Okkenhaug, E. Schuster, E. Blanc, et al. (2008)
FASEB J 22, 807-818
   Abstract »    Full Text »    PDF »
Signaling networks in aging.
E. L. Greer and A. Brunet (2008)
J. Cell Sci. 121, 407-412
   Full Text »    PDF »
Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor.
D. S. Patel, A. Garza-Garcia, M. Nanji, J. J. McElwee, D. Ackerman, P. C. Driscoll, and D. Gems (2008)
Genetics 178, 931-946
   Abstract »    Full Text »    PDF »
Contributions of DNA interstrand cross-links to aging of cells and organisms.
J. Grillari, H. Katinger, and R. Voglauer (2007)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Caloric restriction and genomic stability.
A. R. Heydari, A. Unnikrishnan, L. V. Lucente, and A. Richardson (2007)
Nucleic Acids Res. 35, 7485-7496
   Abstract »    Full Text »    PDF »
Low Utilization of Circulating Glucose after Food Withdrawal in Snell Dwarf Mice.
N. L. Brooks, C. M. Trent, C. F. Raetzsch, K. Flurkey, G. Boysen, M. T. Perfetti, Y.-C. Jeong, S. Klebanov, K. B. Patel, V. R. Khodush, et al. (2007)
J. Biol. Chem. 282, 35069-35077
   Abstract »    Full Text »    PDF »
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
C. T. Murphy, S.-J. Lee, and C. Kenyon (2007)
PNAS 104, 19046-19050
   Abstract »    Full Text »    PDF »
The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation.
J. Zhang (2007)
J. Biol. Chem. 282, 34356-34364
   Abstract »    Full Text »    PDF »
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
A. V. Samuelson, C. E. Carr, and G. Ruvkun (2007)
Genes & Dev. 21, 2976-2994
   Abstract »    Full Text »    PDF »
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals.
A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer (2007)
Physiol Rev 87, 1175-1213
   Abstract »    Full Text »    PDF »
Reduction in Glutathione Peroxidase 4 Increases Life Span Through Increased Sensitivity to Apoptosis.
Q. Ran, H. Liang, Y. Ikeno, W. Qi, T. A. Prolla, L. J. Roberts II, N. Wolf, H. VanRemmen, and A. Richardson (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 932-942
   Abstract »    Full Text »    PDF »
The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensis.
M. Hasshoff, C. Bohnisch, D. Tonn, B. Hasert, and H. Schulenburg (2007)
FASEB J 21, 1801-1812
   Abstract »    Full Text »    PDF »
The emerging role of FOXO transcription factors in pancreatic {beta} cells.
D. A Glauser and W. Schlegel (2007)
J. Endocrinol. 193, 195-207
   Abstract »    Full Text »    PDF »
Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity.
D. Pomplun, A. Voigt, T. J. Schulz, R. Thierbach, A. F. Pfeiffer, and M. Ristow (2007)
PNAS 104, 6377-6381
   Abstract »    Full Text »    PDF »
Liver X Receptor Alpha Associates With Human Life Span.
S. P. Mooijaart, M. Kuningas, R. G. J. Westendorp, J. J. Houwing-Duistermaat, P. E. Slagboom, P. C. N. Rensen, and D. van Heemst (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 343-349
   Abstract »    Full Text »    PDF »
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
G. I. Perez, A. Jurisicova, L. Wise, T. Lipina, M. Kanisek, A. Bechard, Y. Takai, P. Hunt, J. Roder, M. Grynpas, et al. (2007)
PNAS 104, 5229-5234
   Abstract »    Full Text »    PDF »
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis.
C. Li, P. Chen, J. Vaughan, K.-F. Lee, and W. Vale (2007)
PNAS 104, 4206-4211
   Abstract »    Full Text »    PDF »
Vascular Cell Senescence: Contribution to Atherosclerosis.
T. Minamino and I. Komuro (2007)
Circ. Res. 100, 15-26
   Abstract »    Full Text »    PDF »
Cancer Progression in the Transgenic Adenocarcinoma of Mouse Prostate Mouse Is Related to Energy Balance, Body Mass, and Body Composition, but not Food Intake.
D. M. Huffman, M. S. Johnson, A. Watts, A. Elgavish, I. A. Eltoum, and T. R. Nagy (2007)
Cancer Res. 67, 417-424
   Abstract »    Full Text »    PDF »
SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology..
D. Anastasiou and W. Krek (2006)
Physiology 21, 404-410
   Abstract »    Full Text »    PDF »
One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue..
S. B. Racette, E. P. Weiss, D. T. Villareal, H. Arif, K. Steger-May, K. B. Schechtman, L. Fontana, S. Klein, J. O. Holloszy, and The Washington University School of Medicine CALER (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 943-950
   Abstract »    Full Text »    PDF »
Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members..
V. Shukla, X. Coumoul, L. Cao, R.-H. Wang, C. Xiao, X. Xu, S. Ando, S. Yakar, D. LeRoith, and C. Deng (2006)
Cancer Res. 66, 7151-7157
   Abstract »    Full Text »    PDF »
Nitric oxide and mitochondrial biogenesis.
E. Nisoli and M. O. Carruba (2006)
J. Cell Sci. 119, 2855-2862
   Abstract »    Full Text »    PDF »
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism..
L. Qi, J. E. Heredia, J. Y. Altarejos, R. Screaton, N. Goebel, S. Niessen, I. X. MacLeod, C. W. Liew, R. N. Kulkarni, J. Bain, et al. (2006)
Science 312, 1763-1766
   Abstract »    Full Text »    PDF »
From the Cover: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.
M. S. Bonkowski, J. S. Rocha, M. M. Masternak, K. A. Al Regaiey, and A. Bartke (2006)
PNAS 103, 7901-7905
   Abstract »    Full Text »    PDF »
No extension of lifespan by ablation of germ line in Drosophila.
A. I Barnes, J. M Boone, J. Jacobson, L. Partridge, and T. Chapman (2006)
Proc R Soc B 273, 939-947
   Abstract »    Full Text »    PDF »
Genetics of aging: implications for drug discovery and development.
B. J Geesaman (2006)
Am. J. Clinical Nutrition 83, 466S-469S
   Abstract »    Full Text »    PDF »
Energy Restriction Lowers the Expression of Genes Linked to Inflammation, the Cytoskeleton, the Extracellular Matrix, and Angiogenesis in Mouse Adipose Tissue.
Y. Higami, J. L. Barger, G. P. Page, D. B. Allison, S. R. Smith, T. A. Prolla, and R. Weindruch (2006)
J. Nutr. 136, 343-352
   Abstract »    Full Text »    PDF »
Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
P. Mourikis, G. D. Hurlbut, and S. Artavanis-Tsakonas (2006)
PNAS 103, 1307-1312
   Abstract »    Full Text »    PDF »
Extension of chronological life span in yeast by decreased TOR pathway signaling.
R. W. Powers III, M. Kaeberlein, S. D. Caldwell, B. K. Kennedy, and S. Fields (2006)
Genes & Dev. 20, 174-184
   Abstract »    Full Text »    PDF »
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?.
W. Droge (2005)
Phil Trans R Soc B 360, 2355-2372
   Abstract »    Full Text »    PDF »
The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain.
V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther (2005)
Endocr. Rev. 26, 916-943
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1 in Caloric Restriction and Other Models of Longevity.
J. C. Corton and H. M. Brown-Borg (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1494-1509
   Abstract »    Full Text »    PDF »
Oxidative Aging and Insulin Receptor Signaling.
W. Droge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1378-1385
   Abstract »    Full Text »    PDF »
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
X. Liu, N. Jiang, B. Hughes, E. Bigras, E. Shoubridge, and S. Hekimi (2005)
Genes & Dev. 19, 2424-2434
   Abstract »    Full Text »    PDF »
Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS.
E. Nisoli, C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi, et al. (2005)
Science 310, 314-317
   Abstract »    Full Text »    PDF »
Suppression of Aging in Mice by the Hormone Klotho.
H. Kurosu, M. Yamamoto, J. D. Clark, J. V. Pastor, A. Nandi, P. Gurnani, O. P. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi, et al. (2005)
Science 309, 1829-1833
   Abstract »    Full Text »    PDF »
Aging and Longevity: The IGF-1 Enigma.
P. Anversa (2005)
Circ. Res. 97, 411-414
   Full Text »    PDF »
Very Slow Turnover of {beta}-Cells in Aged Adult Mice.
M. Teta, S. Y. Long, L. M. Wartschow, M. M. Rankin, and J. A. Kushner (2005)
Diabetes 54, 2557-2567
   Abstract »    Full Text »    PDF »
A systematic RNAi screen for longevity genes in C. elegans.
B. Hamilton, Y. Dong, M. Shindo, W. Liu, I. Odell, G. Ruvkun, and S. S. Lee (2005)
Genes & Dev. 19, 1544-1555
   Abstract »    Full Text »    PDF »
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria.
S. E. Schriner, N. J. Linford, G. M. Martin, P. Treuting, C. E. Ogburn, M. Emond, P. E. Coskun, W. Ladiges, N. Wolf, H. Van Remmen, et al. (2005)
Science 308, 1909-1911
   Abstract »    Full Text »    PDF »
Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and Perspectives.
L. Plum, F. T. Wunderlich, S. Baudler, W. Krone, and J. C. Bruning (2005)
Physiology 20, 152-161
   Abstract »    Full Text »    PDF »
Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction.
M. D. W. Piper, W. Mair, and L. Partridge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 549-555
   Abstract »    Full Text »    PDF »
Body size, energy metabolism and lifespan.
J. R. Speakman (2005)
J. Exp. Biol. 208, 1717-1730
   Abstract »    Full Text »    PDF »
Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans.
D. Porte Jr., D. G. Baskin, and M. W. Schwartz (2005)
Diabetes 54, 1264-1276
   Abstract »    Full Text »    PDF »
Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding.
E. A. Hsieh, C. M. Chai, and M. K. Hellerstein (2005)
Am J Physiol Endocrinol Metab 288, E965-E972
   Abstract »    Full Text »    PDF »
Estrogen, Insulin, and Dietary Signals Cooperatively Regulate Longevity Signals to Enhance Resistance to Oxidative Stress in Mice.
T. Baba, T. Shimizu, Y.-i. Suzuki, M. Ogawara, K.-i. Isono, H. Koseki, H. Kurosawa, and T. Shirasawa (2005)
J. Biol. Chem. 280, 16417-16426
   Abstract »    Full Text »    PDF »
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes.
T. Shi, F. Wang, E. Stieren, and Q. Tong (2005)
J. Biol. Chem. 280, 13560-13567
   Abstract »    Full Text »    PDF »
Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice.
Z. D. Sharp and A. Bartke (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 293-300
   Abstract »    Full Text »    PDF »
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
S. J. Broughton, M. D. W. Piper, T. Ikeya, T. M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D. J. Withers, S. J. Leevers, et al. (2005)
PNAS 102, 3105-3110
   Abstract »    Full Text »    PDF »
Response to Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body".
M. E. Giannakou, M. Goss, M. A. Junger, E. Hafen, S. J. Leevers, and L. Partridge (2005)
Science 307, 675b
   Full Text »    PDF »
Interdependent Regulation of Insulin Receptor Kinase Activity by ADP and Hydrogen Peroxide.
T. L. Schmitt, A. Hotz-Wagenblatt, H. Klein, and W. Droge (2005)
J. Biol. Chem. 280, 3795-3801
   Abstract »    Full Text »    PDF »
Down-Regulation of a Forkhead Transcription Factor, FOXO3a, Accelerates Cellular Senescence in Human Dermal Fibroblasts.
H. Kyoung Kim, Y. Kyoung Kim, I.-H. Song, S.-H. Baek, S.-R. Lee, J. Hye Kim, and J.-R. Kim (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 4-9
   Abstract »    Full Text »    PDF »
The Influence of Genes on the Aging Process of Mice: A Statistical Assessment of the Genetics of Aging.
J. P. de Magalhaes, J. A. S. Cabral, and D. Magalhaes (2005)
Genetics 169, 265-274
   Abstract »    Full Text »    PDF »
Hormone-Treated Snell Dwarf Mice Regain Fertility But Remain Long Lived and Disease Resistant.
M. Vergara, M. Smith-Wheelock, J. M. Harper, R. Sigler, and R. A. Miller (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, 1244-1250
   Abstract »    Full Text »    PDF »
Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance.
J. J. McElwee, E. Schuster, E. Blanc, J. H. Thomas, and D. Gems (2004)
J. Biol. Chem. 279, 44533-44543
   Abstract »    Full Text »    PDF »
Not Wisely but Too Well: Aging as a Cost of Neuroendocrine Activity.
C. V. Mobbs (2004)
Sci. Aging Knowl. Environ. 2004, pe33
   Abstract »    Full Text »
Restriction of Dietary Energy and Protein Induces Molecular Changes in Young Porcine Skeletal Muscles.
N. da Costa, C. McGillivray, Q. Bai, J. D. Wood, G. Evans, and K.-C. Chang (2004)
J. Nutr. 134, 2191-2199
   Abstract »    Full Text »    PDF »
Deletion of the Intestinal Peptide Transporter Affects Insulin and TOR Signaling in Caenorhabditis elegans.
B. Meissner, M. Boll, H. Daniel, and R. Baumeister (2004)
J. Biol. Chem. 279, 36739-36745
   Abstract »    Full Text »    PDF »
Murine Models of Life Span Extension.
J. K. Quarrie and K. T. Riabowol (2004)
Sci. Aging Knowl. Environ. 2004, re5
   Abstract »    Full Text »    PDF »
Tissue-specific insulin resistance.
A G Unnikrishnan (2004)
Postgrad. Med. J. 80, 435
   Full Text »    PDF »
Intrinsic Heterogeneity in Adipose Tissue of Fat-specific Insulin Receptor Knock-out Mice Is Associated with Differences in Patterns of Gene Expression.
M. Bluher, M.-E. Patti, S. Gesta, B. B. Kahn, and C. R. Kahn (2004)
J. Biol. Chem. 279, 31891-31901
   Abstract »    Full Text »    PDF »
Role of Insulin Action and Cell Size on Protein Expression Patterns in Adipocytes.
M. Bluher, L. Wilson-Fritch, J. Leszyk, P. G. Laustsen, S. Corvera, and C. R. Kahn (2004)
J. Biol. Chem. 279, 31902-31909
   Abstract »    Full Text »    PDF »
Selective disruption of PPAR{gamma}2 impairs the development of adipose tissue and insulin sensitivity.
J. Zhang, M. Fu, T. Cui, C. Xiong, K. Xu, W. Zhong, Y. Xiao, D. Floyd, J. Liang, E. Li, et al. (2004)
PNAS 101, 10703-10708
   Abstract »    Full Text »    PDF »
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body.
M. E. Giannakou, M. Goss, M. A. Junger, E. Hafen, S. J. Leevers, and L. Partridge (2004)
Science 305, 361
   Abstract »    Full Text »    PDF »
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase.
H. Y. Cohen, C. Miller, K. J. Bitterman, N. R. Wall, B. Hekking, B. Kessler, K. T. Howitz, M. Gorospe, R. de Cabo, and D. A. Sinclair (2004)
Science 305, 390-392
   Abstract »    Full Text »    PDF »
The Future of Aging Interventions: Current Status of Efforts to Measure and Modulate the Biological Rate of Aging.
H. R. Warner (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B692-B696
   Abstract »    Full Text »    PDF »
The Future of Aging Interventions: The Human Life Span Is Not That Limited: The Effect of Multiple Longevity Phenotypes.
R. Arking, V. Novoseltsev, and J. Novoseltseva (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B697-B704
   Abstract »    Full Text »    PDF »
Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
H. J. Goren, R. N. Kulkarni, and C. R. Kahn (2004)
Endocrinology 145, 3307-3323
   Abstract »    Full Text »    PDF »
Inside Insulin Signaling, Communication Is Key to Long Life.
A. Antebi (2004)
Sci. Aging Knowl. Environ. 2004, pe25
   Abstract »    Full Text »
Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans.
M. Fujii, Y. Matsumoto, N. Tanaka, K. Miki, T. Suzuki, N. Ishii, and D. Ayusawa (2004)
J. Biol. Chem. 279, 20277-20282
   Abstract »    Full Text »    PDF »
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes.
R. T. Watson, M. Kanzaki, and J. E. Pessin (2004)
Endocr. Rev. 25, 177-204
   Abstract »    Full Text »    PDF »
Mouse Models of Insulin Resistance.
A. NANDI, Y. KITAMURA, C. R. KAHN, and D. ACCILI (2004)
Physiol Rev 84, 623-647
   Abstract »    Full Text »    PDF »
Serum leptin level is a regulator of bone mass.
F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, S. M. Ware, W. J. Craigen, et al. (2004)
PNAS 101, 3258-3263
   Abstract »    Full Text »    PDF »
Modulation of mammalian life span by the short isoform of p53.
B. Maier, W. Gluba, B. Bernier, T. Turner, K. Mohammad, T. Guise, A. Sutherland, M. Thorner, and H. Scrable (2004)
Genes & Dev. 18, 306-319
   Abstract »    Full Text »    PDF »
Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism.
P. J. Havel (2004)
Diabetes 53, S143-151
   Abstract »    Full Text »
Effect of caloric restriction on mitochondrial reactive oxygen species production and bioenergetics: reversal by insulin.
A. J. Lambert and B. J. Merry (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R71-R79
   Abstract »    Full Text »
Power to the People.
R. J. Davenport (2003)
Sci. Aging Knowl. Environ. 2003, ns8-8
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)