Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis
De-Yu Xie,1Shashi B. Sharma,1Nancy L. Paiva,1Daneel Ferreira,2Richard A. Dixon1*
Condensed tannins (CTs) are flavonoid oligomers, many of
which have beneficial effects on animal and human health. The flavanol(-)-epicatechin is a component of many CTs and contributes toflavor
and astringency in tea and wine. We show that the BANYULS(BAN) genes from Arabidopsis thaliana and
Medicago truncatulaencode anthocyanidin reductase, which
converts anthocyanidinsto their corresponding
2,3-cis-flavan-3-ols. Ectopic expressionof BAN in tobacco
flower petals and Arabidopsis leaves resultsin loss of
anthocyanins and accumulation of CTs.
1 Plant Biology Division, Samuel Roberts Noble
Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA.
2 National Center for Natural Products Research,
School of Pharmacy, University of Mississippi, University, MS 38677, USA.
*
To whom correspondence should be addressed. E-mail:
radixon{at}noble.org
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
Bonnie Bartel and Seiichi P. T. Matsuda (17 January 2003) Science299 (5605), 352.
[DOI: 10.1126/science.1081096] |Summary »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Transcription Factor VvMYB5b Contributes to the Regulation of Anthocyanin and Proanthocyanidin Biosynthesis in Developing Grape Berries.
L. Deluc, J. Bogs, A. R. Walker, T. Ferrier, A. Decendit, J.-M. Merillon, S. P. Robinson, and F. Barrieu (2008)
Plant Physiology
147, 2041-2053
|Abstract »|Full Text »|PDF »
Early Steps in Proanthocyanidin Biosynthesis in the Model Legume Medicago truncatula.
Y. Pang, G. J. Peel, E. Wright, Z. Wang, and R. A. Dixon (2007)
Plant Physiology
145, 601-615
|Abstract »|Full Text »|PDF »
The Arabidopsis MATE Transporter TT12 Acts as a Vacuolar Flavonoid/H+-Antiporter Active in Proanthocyanidin-Accumulating Cells of the Seed Coat.
K. Marinova, L. Pourcel, B. Weder, M. Schwarz, D. Barron, J.-M. Routaboul, I. Debeaujon, and M. Klein (2007)
PLANT CELL
19, 2023-2038
|Abstract »|Full Text »|PDF »
The Grapevine Transcription Factor VvMYBPA1 Regulates Proanthocyanidin Synthesis during Fruit Development.
J. Bogs, F. W. Jaffe, A. M. Takos, A. R. Walker, and S. P. Robinson (2007)
Plant Physiology
143, 1347-1361
|Abstract »|Full Text »|PDF »
Ectopic Expression of a Basic Helix-Loop-Helix Gene Transactivates Parallel Pathways of Proanthocyanidin Biosynthesis. Structure, Expression Analysis, and Genetic Control of Leucoanthocyanidin 4-Reductase and Anthocyanidin Reductase Genes in Lotus corniculatus.
F. Paolocci, M. P. Robbins, L. Madeo, S. Arcioni, S. Martens, and F. Damiani (2007)
Plant Physiology
143, 504-516
|Abstract »|Full Text »|PDF »
Expression of VvmybA1 Gene and Anthocyanin Accumulation in Various Grape Organs.
S.-T. Jeong, N. Goto-Yamamoto, K. Hashizume, S. Kobayashi, and M. Esaka (2006)
Am. J. Enol. Vitic.
57, 507-510
|Abstract »|Full Text »|PDF »
Cultural Practice and Environmental Impacts on the Flavonoid Composition of Grapes and Wine: A Review of Recent Research.
M. O. Downey, N. K. Dokoozlian, and M. P. Krstic (2006)
Am. J. Enol. Vitic.
57, 257-268
|Abstract »|Full Text »|PDF »
Mechanistic Study on the Oxidation of Anthocyanidin Synthase by Quantum Mechanical Calculation.
J.-i. Nakajima, Y. Sato, T. Hoshino, M. Yamazaki, and K. Saito (2006)
J. Biol. Chem.
281, 21387-21398
|Abstract »|Full Text »|PDF »
Identification of Genes with Potential Roles in Apple Fruit Development and Biochemistry through Large-Scale Statistical Analysis of Expressed Sequence Tags.
S. Park, N. Sugimoto, M. D. Larson, R. Beaudry, and S. van Nocker (2006)
Plant Physiology
141, 811-824
|Abstract »|Full Text »|PDF »
Characterization of a Grapevine R2R3-MYB Transcription Factor That Regulates the Phenylpropanoid Pathway.
L. Deluc, F. Barrieu, C. Marchive, V. Lauvergeat, A. Decendit, T. Richard, J.-P. Carde, J.-M. Merillon, and S. Hamdi (2006)
Plant Physiology
140, 499-511
|Abstract »|Full Text »|PDF »
Anthocyanidin Reductase Gene Expression and Accumulation of Flavan-3-ols in Grape Berry.
A. Fujita, N. Soma, N. Goto-Yamamoto, H. Shindo, T. Kakuta, T. Koizumi, and K. Hashizume (2005)
Am. J. Enol. Vitic.
56, 336-342
|Abstract »|Full Text »|PDF »
Proanthocyanidin Synthesis and Expression of Genes Encoding Leucoanthocyanidin Reductase and Anthocyanidin Reductase in Developing Grape Berries and Grapevine Leaves.
J. Bogs, M. O. Downey, J. S. Harvey, A. R. Ashton, G. J. Tanner, and S. P. Robinson (2005)
Plant Physiology
139, 652-663
|Abstract »|Full Text »|PDF »
Genome-Wide Analysis of Hydrogen Peroxide-Regulated Gene Expression in Arabidopsis Reveals a High Light-Induced Transcriptional Cluster Involved in Anthocyanin Biosynthesis.
S. Vanderauwera, P. Zimmermann, S. Rombauts, S. Vandenabeele, C. Langebartels, W. Gruissem, D. Inze, and F. Van Breusegem (2005)
Plant Physiology
139, 806-821
|Abstract »|Full Text »|PDF »
Light and an exogenous transcription factor qualitatively and quantitatively affect the biosynthetic pathway of condensed tannins in Lotus corniculatus leaves.
F. Paolocci, T. Bovone, N. Tosti, S. Arcioni, and F. Damiani (2005)
J. Exp. Bot.
56, 1093-1103
|Abstract »|Full Text »|PDF »
A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana.
I. R. Baxter, J. C. Young, G. Armstrong, N. Foster, N. Bogenschutz, T. Cordova, W. A. Peer, S. P. Hazen, A. S. Murphy, and J. F. Harper (2005)
PNAS
102, 2649-2654
|Abstract »|Full Text »|PDF »
Expression of antiapoptotic genes bcl-xL and ced-9 in tomato enhances tolerance to viral-induced necrosis and abiotic stress.
Transcriptional Programs of Early Reproductive Stages in Arabidopsis.
L. Hennig, W. Gruissem, U. Grossniklaus, and C. Kohler (2004)
Plant Physiology
135, 1765-1775
|Abstract »|Full Text »|PDF »
Molecular and Biochemical Analysis of Two cDNA Clones Encoding Dihydroflavonol-4-Reductase from Medicago truncatula.
D.-Y. Xie, L. A. Jackson, J. D. Cooper, D. Ferreira, and N. L. Paiva (2004)
Plant Physiology
134, 979-994
|Abstract »|Full Text »|PDF »
Proanthocyanidin-Accumulating Cells in Arabidopsis Testa: Regulation of Differentiation and Role in Seed Development.
I. Debeaujon, N. Nesi, P. Perez, M. Devic, O. Grandjean, M. Caboche, and L. Lepiniec (2003)
PLANT CELL
15, 2514-2531
|Abstract »|Full Text »|PDF »
Communication between the Maternal Testa and the Embryo and/or Endosperm Affect Testa Attributes in Tomato.
A. B. Downie, D. Zhang, L. M.A. Dirk, R. R. Thacker, J. A. Pfeiffer, J. L. Drake, A. A. Levy, D. A. Butterfield, J. W. Buxton, and J. C. Snyder (2003)
Plant Physiology
133, 145-160
|Abstract »|Full Text »|PDF »
Proanthocyanidin Biosynthesis in Plants: PURIFICATION OF LEGUME LEUCOANTHOCYANIDIN REDUCTASE AND MOLECULAR CLONING OF ITS cDNA.
G. J. Tanner, K. T. Francki, S. Abrahams, J. M. Watson, P. J. Larkin, and A. R. Ashton (2003)
J. Biol. Chem.
278, 31647-31656
|Abstract »|Full Text »|PDF »
Expression of Anthocyanins and Proanthocyanidins after Transformation of Alfalfa with Maize Lc.
H. Ray, M. Yu, P. Auser, L. Blahut-Beatty, B. McKersie, S. Bowley, N. Westcott, B. Coulman, A. Lloyd, and M. Y. Gruber (2003)
Plant Physiology
132, 1448-1463
|Abstract »|Full Text »|PDF »
Legume Natural Products: Understanding and Manipulating Complex Pathways for Human and Animal Health.
R. A. Dixon and L. W. Sumner (2003)
Plant Physiology
131, 878-885
|Full Text »|PDF »
