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Science 17 January 2003:
Vol. 299. no. 5605, pp. 396 - 399
DOI: 10.1126/science.1078540

Reports

Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis

De-Yu Xie,1 Shashi B. Sharma,1 Nancy L. Paiva,1 Daneel Ferreira,2 Richard A. Dixon1*

Condensed tannins (CTs) are flavonoid oligomers, many of which have beneficial effects on animal and human health. The flavanol (-)-epicatechin is a component of many CTs and contributes to flavor and astringency in tea and wine. We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Medicago truncatula encode anthocyanidin reductase, which converts anthocyanidins to their corresponding 2,3-cis-flavan-3-ols. Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs.

1 Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA.
2 National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
*   To whom correspondence should be addressed. E-mail: radixon{at}noble.org


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