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Noah A. Rosenberg,1*Jonathan K. Pritchard,2James L. Weber,3Howard M. Cann,4Kenneth K. Kidd,5Lev A. Zhivotovsky,6Marcus W. Feldman7
We studied human population structure using genotypes at
377 autosomal microsatellite loci in 1056 individuals from 52 populations.Within-population differences among individuals account
for 93to 95% of genetic variation; differences among major groups
constituteonly 3 to 5%. Nevertheless, without using prior information
aboutthe origins of individuals, we identified six main genetic
clusters,five of which correspond to major geographic regions, and
subclustersthat often correspond to individual populations. General
agreementof genetic and predefined populations suggests that
self-reportedancestry can facilitate assessments of epidemiological
risks butdoes not obviate the need to use genetic information in
geneticassociation studies.
1 Molecular and Computational Biology, 1042 West
36th Place DRB 289, University of Southern California, Los Angeles, CA
90089, USA.
2 Department of Human Genetics,
University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.
3 Center for Medical Genetics, Marshfield Medical
Research Foundation, Marshfield, WI 54449, USA.
4 Foundation Jean Dausset-Centre d'Etude
du Polymorphisme Humain (CEPH), 27 rue Juliette Dodu, 75010 Paris,
France.
5 Department of Genetics, Yale University
School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
6 Vavilov Institute of General Genetics, Russian
Academy of Sciences, 3 Gubkin Street, Moscow 117809, Russia.
7 Department of Biological Sciences, Stanford
University, Stanford, CA 94305, USA.
*
To whom correspondence should be addressed. E-mail:
noahr{at}usc.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
TECHNICAL COMMENTS
Laurent Excoffier and Grant Hamilton (20 June 2003) Science300 (5627), 1877b.
[DOI: 10.1126/science.1083411] |Full Text »|PDF »
TECHNICAL COMMENTS
Noah A. Rosenberg, Jonathan K. Pritchard, James L. Weber, Howard M. Cann, Kenneth K. Kidd, Lev A. Zhivotovsky, and Marcus W. Feldman (20 June 2003) Science300 (5627), 1877c.
[DOI: 10.1126/science.1084688] |Full Text »|PDF »
LETTERS
John Hardy, Andrew Singleton, and Katrina Gwinn-Hardy (2 May 2003) Science300 (5620), 739.
[DOI: 10.1126/science.300.5620.739] |Full Text »|PDF »
PERSPECTIVES
Mary-Claire King and Arno G. Motulsky (20 December 2002) Science298 (5602), 2342.
[DOI: 10.1126/science.1080373] |Summary »|Full Text »|PDF »
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