Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Focus on Europe

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 December 2002:
Vol. 298. no. 5600, pp. 1946 - 1950
DOI: 10.1126/science.1072162
Prev | Table of Contents | Next

Review

Anterior-Posterior Polarity in C. elegans and Drosophila--PARallels and Differences

Jason Pellettieri, Geraldine Seydoux*

The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.

Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed. E-mail: gseydoux{at}jhmi.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Par-3-mediated Junctional Localization of the Lipid Phosphatase PTEN Is Required for Cell Polarity Establishment.
W. Feng, H. Wu, L.-N. Chan, and M. Zhang (2008)
J. Biol. Chem. 283, 23440-23449
   Abstract »    Full Text »    PDF »
Accurate Balance of the Polarity Kinase MARK2/Par-1 Is Required for Proper Cortical Neuronal Migration.
T. Sapir, S. Sapoznik, T. Levy, D. Finkelshtein, A. Shmueli, T. Timm, E.-M. Mandelkow, and O. Reiner (2008)
J. Neurosci. 28, 5710-5720
   Abstract »    Full Text »    PDF »
PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC.
O. Ossipova, J. Tabler, J. B. A. Green, and S. Y. Sokol (2007)
Development 134, 4297-4306
   Abstract »    Full Text »    PDF »
PAR-6 is required for junction formation but not apicobasal polarization in C. elegans embryonic epithelial cells.
R. Totong, A. Achilleos, and J. Nance (2007)
Development 134, 1259-1268
   Abstract »    Full Text »    PDF »
Molecular Basis of RNA Recognition by the Embryonic Polarity Determinant MEX-5.
J. M. Pagano, B. M. Farley, L. M. McCoig, and S. P. Ryder (2007)
J. Biol. Chem. 282, 8883-8894
   Abstract »    Full Text »    PDF »
Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation.
G. Zeng, S. M. Taylor, J. R. McColm, N. C. Kappas, J. B. Kearney, L. H. Williams, M. E. Hartnett, and V. L. Bautch (2007)
Blood 109, 1345-1352
   Abstract »    Full Text »    PDF »
Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis.
J. R. Tenlen, J. A. Schisa, S. J. Diede, and B. D. Page (2006)
Genetics 174, 1933-1945
   Abstract »    Full Text »    PDF »
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
O. Goransson, M. Deak, S. Wullschleger, N. A. Morrice, A. R. Prescott, and D. R. Alessi (2006)
J. Cell Sci. 119, 4059-4070
   Abstract »    Full Text »    PDF »
Structural Variations in the Catalytic and Ubiquitin-associated Domains of Microtubule-associated Protein/Microtubule Affinity Regulating Kinase (MARK) 1 and MARK2.
A. Marx, C. Nugoor, J. Muller, S. Panneerselvam, T. Timm, M. Bilang, E. Mylonas, D. I. Svergun, E.-M. Mandelkow, and E. Mandelkow (2006)
J. Biol. Chem. 281, 27586-27599
   Abstract »    Full Text »    PDF »
Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis.
A. Kibardin, O. Ossipova, and S. Y. Sokol (2006)
Development 133, 2845-2854
   Abstract »    Full Text »    PDF »
The PAR-aPKC system: lessons in polarity..
A. Suzuki and S. Ohno (2006)
J. Cell Sci. 119, 979-987
   Abstract »    Full Text »    PDF »
The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.
J. Steinhauer and D. Kalderon (2005)
Development 132, 5515-5525
   Abstract »    Full Text »    PDF »
PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.
C. A Moore and M. Zernicka-Goetz (2005)
Reproduction 130, 311-320
   Abstract »    Full Text »    PDF »
PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic Actin.
D. Matenia, B. Griesshaber, X.-y. Li, A. Thiessen, C. Johne, J. Jiao, E. Mandelkow, and E.-M. Mandelkow (2005)
Mol. Biol. Cell 16, 4410-4422
   Abstract »    Full Text »    PDF »
Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.
W. von Stein, A. Ramrath, A. Grimm, M. Muller-Borg, and A. Wodarz (2005)
Development 132, 1675-1686
   Abstract »    Full Text »    PDF »
aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development.
A. D. Chalmers, M. Pambos, J. Mason, S. Lang, C. Wylie, and N. Papalopulu (2005)
Development 132, 977-986
   Abstract »    Full Text »    PDF »
Cdc42 Mediates Nucleus Movement and MTOC Polarization in Swiss 3T3 Fibroblasts under Mechanical Shear Stress.
J. S.H. Lee, M. I. Chang, Y. Tseng, and D. Wirtz (2005)
Mol. Biol. Cell 16, 871-880
   Abstract »    Full Text »    PDF »
The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly.
J.-C. Labbe, E. K. McCarthy, and B. Goldstein (2004)
J. Cell Biol. 167, 245-256
   Abstract »    Full Text »    PDF »
The mouse kinome: Discovery and comparative genomics of all mouse protein kinases.
S. Caenepeel, G. Charydczak, S. Sudarsanam, T. Hunter, and G. Manning (2004)
PNAS 101, 11707-11712
   Abstract »    Full Text »    PDF »
zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans.
R. Sonneville and P. Gonczy (2004)
Development 131, 3527-3543
   Abstract »    Full Text »    PDF »
CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans.
J. Liu, S. Vasudevan, and E. T. Kipreos (2004)
Development 131, 3513-3525
   Abstract »    Full Text »    PDF »
PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.
S. Aono, R. Legouis, W. A. Hoose, and K. J. Kemphues (2004)
Development 131, 2865-2874
   Abstract »    Full Text »    PDF »
Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network.
M. Brajenovic, G. Joberty, B. Kuster, T. Bouwmeester, and G. Drewes (2004)
J. Biol. Chem. 279, 12804-12811
   Abstract »    Full Text »    PDF »
Anaphase-Promoting Complex in Caenorhabditis elegans.
F. M. Yeong (2004)
Mol. Cell. Biol. 24, 2215-2225
   Full Text »    PDF »
C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation.
J. Nance, E. M. Munro, and J. R. Priess (2003)
Development 130, 5339-5350
   Abstract »    Full Text »    PDF »
Visualizing the distribution and transport of mRNAs in living cells.
D. P. Bratu, B.-J. Cha, M. M. Mhlanga, F. R. Kramer, and S. Tyagi (2003)
PNAS 100, 13308-13313
   Abstract »    Full Text »    PDF »
Composition and function of PDZ protein complexes during cell polarization.
M. H. Roh and B. Margolis (2003)
Am J Physiol Renal Physiol 285, F377-F387
   Abstract »    Full Text »    PDF »
The Distribution of Active Force Generators Controls Mitotic Spindle Position.
S. W. Grill, J. Howard, E. Schaffer, E. H. K. Stelzer, and A. A. Hyman (2003)
Science 301, 518-521
   Abstract »    Full Text »    PDF »
Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos.
K. Colombo, S. W. Grill, R. J. Kimple, F. S. Willard, D. P. Siderovski, and P. Gonczy (2003)
Science 300, 1957-1961
   Abstract »    Full Text »    PDF »
Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.
D. C. Shakes, P. L. Sadler, J. M. Schumacher, M. Abdolrasulnia, and A. Golden (2003)
Development 130, 1605-1620
   Abstract »    Full Text »    PDF »
Composition and Formation of Intercellular Junctions in Epithelial Cells.
E. Knust and O. Bossinger (2002)
Science 298, 1955-1959
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)