Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GE and Science Prize for Young Life Scientists

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 December 2002:
Vol. 298. no. 5600, pp. 1912 - 1934
DOI: 10.1126/science.1075762
Prev | Table of Contents | Next

Review

The Protein Kinase Complement of the Human Genome

G. Manning,1* D. B. Whyte,1 R. Martinez,1 T. Hunter,2 S. Sudarsanam13

We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons.

1 SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA.
2 Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3 Genomics and Biotechnology, Pharmacia Corporation, 230 East Grand Avenue, South San Francisco, CA 94080, USA.
*   To whom correspondence should be addressed. E-mail: gerard-manning{at}sugen.com

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fibronectin Type I Repeat Is a Nonactivating Ligand for EphA1 and Inhibits ATF3-dependent Angiogenesis.
J. Masuda, R. Usui, and Y. Maru (2008)
J. Biol. Chem. 283, 13148-13155
   Abstract »    Full Text »    PDF »
Pathways Leading to Phosphorylation of P450c17 and to the Posttranslational Regulation of Androgen Biosynthesis.
M. K. Tee, Q. Dong, and W. L. Miller (2008)
Endocrinology 149, 2667-2677
   Abstract »    Full Text »    PDF »
Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.
L. Li, C. Wu, H. Huang, K. Zhang, J. Gan, and S. S.-C. Li (2008)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Defining the Specificity Space of the Human Src Homology 2 Domain.
H. Huang, L. Li, C. Wu, D. Schibli, K. Colwill, S. Ma, C. Li, P. Roy, K. Ho, Z. Songyang, et al. (2008)
Mol. Cell. Proteomics 7, 768-784
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin-Dependent Protein Kinase II{delta} and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure.
J. Bossuyt, K. Helmstadter, X. Wu, H. Clements-Jewery, R. S. Haworth, M. Avkiran, J. L. Martin, S. M. Pogwizd, and D. M. Bers (2008)
Circ. Res. 102, 695-702
   Abstract »    Full Text »    PDF »
Meta-prediction of phosphorylation sites with weighted voting and restricted grid search parameter selection.
J. Wan, S. Kang, C. Tang, J. Yan, Y. Ren, J. Liu, X. Gao, A. Banerjee, L. B. M. Ellis, and T. Li (2008)
Nucleic Acids Res. 36, e22
   Abstract »    Full Text »    PDF »
Prediction of Cancer Driver Mutations in Protein Kinases.
A. Torkamani and N. J. Schork (2008)
Cancer Res. 68, 1675-1682
   Abstract »    Full Text »    PDF »
An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.
G. Mayer, B. Wulffen, C. Huber, J. Brockmann, B. Flicke, L. Neumann, D. Hafenbradl, B. M. Klebl, M. J. Lohse, C. Krasel, et al. (2008)
RNA 14, 524-534
   Abstract »    Full Text »    PDF »
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion.
M. Kim, H.-R. Jang, J.-H. Kim, S.-M. Noh, K.-S. Song, J.-S. Cho, H.-Y. Jeong, J. C. Norman, P. T. Caswell, G. H. Kang, et al. (2008)
Carcinogenesis 29, 629-637
   Abstract »    Full Text »    PDF »
Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A..
J.-i. Yomoda, M. Muraki, N. Kataoka, T. Hosoya, M. Suzuki, M. Hagiwara, and H. Kimura (2008)
Genes Cells 13, 233-244
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase {epsilon} Regulates Shc Signaling in a Kinase-specific Manner: INCREASING COHERENCE IN TYROSINE PHOSPHATASE SIGNALING.
J. Kraut-Cohen, W. J. Muller, and A. Elson (2008)
J. Biol. Chem. 283, 4612-4621
   Abstract »    Full Text »    PDF »
Characterization of Some Molecular Mechanisms Governing Autoactivation of the Catalytic Domain of the Anaplastic Lymphoma Kinase.
C. J. Tartari, R. H. Gunby, A. M. L. Coluccia, R. Sottocornola, B. Cimbro, L. Scapozza, A. Donella-Deana, L. A. Pinna, and C. Gambacorti-Passerini (2008)
J. Biol. Chem. 283, 3743-3750
   Abstract »    Full Text »    PDF »
Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels.
K.-S. Park, J.-W. Yang, E. Seikel, and J. S. Trimmer (2008)
Physiology 23, 49-57
   Abstract »    Full Text »    PDF »
Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis.
P. Finetti, N. Cervera, E. Charafe-Jauffret, C. Chabannon, C. Charpin, M. Chaffanet, J. Jacquemier, P. Viens, D. Birnbaum, and F. Bertucci (2008)
Cancer Res. 68, 767-776
   Abstract »    Full Text »    PDF »
Protein Kinase D in the Cardiovascular System: Emerging Roles in Health and Disease.
M. Avkiran, A. J. Rowland, F. Cuello, and R. S. Haworth (2008)
Circ. Res. 102, 157-163
   Abstract »    Full Text »    PDF »
Evolutionary Radiation Pattern of Novel Protein Phosphatases Revealed by Analysis of Protein Data from the Completely Sequenced Genomes of Humans, Green Algae, and Higher Plants.
D. Kerk, G. Templeton, and G. B.G. Moorhead (2008)
Plant Physiology 146, 351-367
   Abstract »    Full Text »    PDF »
Cyclic Nucleotide-dependent Protein Kinases Inhibit Binding of 14-3-3 to the GTPase-activating Protein Rap1GAP2 in Platelets.
M. Hoffmeister, P. Riha, O. Neumuller, O. Danielewski, J. Schultess, and A. P. Smolenski (2008)
J. Biol. Chem. 283, 2297-2306
   Abstract »    Full Text »    PDF »
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
P. Uawithya, T. Pisitkun, B. E. Ruttenberg, and M. A. Knepper (2008)
Physiol Genomics 32, 229-253
   Abstract »    Full Text »    PDF »
Activation of the SPS Amino Acid-Sensing Pathway in Saccharomyces cerevisiae Correlates with the Phosphorylation State of a Sensor Component, Ptr3.
Z. Liu, J. Thornton, M. Spirek, and R. A. Butow (2008)
Mol. Cell. Biol. 28, 551-563
   Abstract »    Full Text »    PDF »
Allosteric cooperativity in protein kinase A.
L. R. Masterson, A. Mascioni, N. J. Traaseth, S. S. Taylor, and G. Veglia (2008)
PNAS 105, 506-511
   Abstract »    Full Text »    PDF »
Identification of Functionally Distinct Regions That Mediate Biological Activity of the Protein Kinase A Homolog Tpk2.
E. J. Kennedy, G. Ghosh, and L. Pillus (2008)
J. Biol. Chem. 283, 1084-1093
   Abstract »    Full Text »    PDF »
PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.
W. Gong, D. Zhou, Y. Ren, Y. Wang, Z. Zuo, Y. Shen, F. Xiao, Q. Zhu, A. Hong, X. Zhou, et al. (2008)
Nucleic Acids Res. 36, D679-D683
   Abstract »    Full Text »    PDF »
Comparison of Miniaturized Time-Resolved Fluorescence Resonance Energy Transfer and Enzyme-Coupled Luciferase High-Throughput Screening Assays to Discover Inhibitors of Rho-Kinase II (ROCK-II).
T. Schroter, D. Minond, A. Weiser, C. Dao, J. Habel, T. Spicer, P. Chase, P. Baillargeon, L. Scampavia, S. Schurer, et al. (2008)
J Biomol Screen 13, 17-28
   Abstract »    PDF »
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells.
W. Xiong, Y. Chen, H. Wang, H. Wang, H. Wu, Q. Lu, and D. Han (2008)
Reproduction 135, 77-87
   Abstract »    Full Text »    PDF »
PhosphoBlast, a Computational Tool for Comparing Phosphoprotein Signatures among Large Datasets.
Y. Wang and R. L. Klemke (2008)
Mol. Cell. Proteomics 7, 145-162
   Abstract »    Full Text »    PDF »
Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation.
I. Bartova, J. Koca, and M. Otyepka (2008)
Protein Sci. 17, 22-33
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor Receptor Phosphorylates Protein Kinase C {delta} at Tyr332 to form a Trimeric Complex with p66Shc in the H2O2-stimulated Cells.
M. Morita, H. Matsuzaki, T. Yamamoto, Y. Fukami, and U. Kikkawa (2008)
J. Biochem. 143, 31-38
   Abstract »    Full Text »    PDF »
Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5.
N. Gerits, T. Mikalsen, S. Kostenko, A. Shiryaev, M. Johannessen, and U. Moens (2007)
J. Biol. Chem. 282, 37232-37243
   Abstract »    Full Text »    PDF »
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
O. Fedorov, B. Marsden, V. Pogacic, P. Rellos, S. Muller, A. N. Bullock, J. Schwaller, M. Sundstrom, and S. Knapp (2007)
PNAS 104, 20523-20528
   Abstract »    Full Text »    PDF »
The Ste20-like kinase SvkA of Dictyostelium discoideum is essential for late stages of cytokinesis.
M. Rohlfs, R. Arasada, P. Batsios, J. Janzen, and M. Schleicher (2007)
J. Cell Sci. 120, 4345-4354
   Abstract »    Full Text »    PDF »
Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression.
X. Li, Y.-K. Lee, J.-C. Jeng, Y. Yen, D. C. Schultz, H.-M. Shih, and D. K. Ann (2007)
J. Biol. Chem. 282, 36177-36189
   Abstract »    Full Text »    PDF »
Expression of Serine/Threonine Protein-Kinases and Related Factors in Normal Monkey and Human Retinas: The Mechanistic Understanding of a CDK2 Inhibitor Induced Retinal Toxicity.
G. Saturno, M. Pesenti, C. Cavazzoli, A. Rossi, A. M. Giusti, B. Gierke, M. Pawlak, and M. Venturi (2007)
Toxicol Pathol 35, 972-983
   Abstract »    PDF »
Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines.
J. E. Ruhe, S. Streit, S. Hart, C.-H. Wong, K. Specht, P. Knyazev, T. Knyazeva, L. S. Tay, H. L. Loo, P. Foo, et al. (2007)
Cancer Res. 67, 11368-11376
   Abstract »    Full Text »    PDF »
Renal Cell Carcinoma: New Developments in Molecular Biology and Potential for Targeted Therapies.
L. J. Costa and H. A. Drabkin (2007)
Oncologist 12, 1404-1415
   Abstract »    Full Text »    PDF »
Chemical Genetics Define the Roles of p38{alpha} and p38 in Acute and Chronic Inflammation.
S. J. O'Keefe, J. S. Mudgett, S. Cupo, J. N. Parsons, N. A. Chartrain, C. Fitzgerald, S.-L. Chen, K. Lowitz, C. Rasa, D. Visco, et al. (2007)
J. Biol. Chem. 282, 34663-34671
   Abstract »    Full Text »    PDF »
A Novel Tyrosine Phosphorylation Site in Protein Kinase D Contributes to Oxidative Stress-mediated Activation.
H. Doppler and P. Storz (2007)
J. Biol. Chem. 282, 31873-31881
   Abstract »    Full Text »    PDF »
Highly Efficient Phosphopeptide Enrichment by Calcium Phosphate Precipitation Combined with Subsequent IMAC Enrichment.
X. Zhang, J. Ye, O. N. Jensen, and P. Roepstorff (2007)
Mol. Cell. Proteomics 6, 2032-2042
   Abstract »    Full Text »    PDF »
Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics.
L.-Y. Choong, S. Lim, M. C.-S. Loh, X. Man, Y. Chen, W. Toy, M. Pan, C.-S. Chen, A. Poonepalli, M. P. Hande, et al. (2007)
Mol. Cancer Ther. 6, 2828-2842
   Abstract »    Full Text »    PDF »
Properties, Regulation, and in Vivo Functions of a Novel Protein Kinase D: CAENORHABDITIS ELEGANS DKF-2 LINKS DIACYLGLYCEROL SECOND MESSENGER TO THE REGULATION OF STRESS RESPONSES AND LIFE SPAN.
H. Feng, M. Ren, L. Chen, and C. S. Rubin (2007)
J. Biol. Chem. 282, 31273-31288
   Abstract »    Full Text »    PDF »
Signalling through kinase-defective domains: the prevalence of atypical receptor-like kinases in plants.
E. Castells and J. M. Casacuberta (2007)
J. Exp. Bot.
   Abstract »    Full Text »    PDF »
Vaccinia-Related Kinase 2 Modulates the Stress Response to Hypoxia Mediated by TAK1.
S. Blanco, C. Santos, and P. A. Lazo (2007)
Mol. Cell. Biol. 27, 7273-7283
   Abstract »    Full Text »    PDF »
Differential phosphorylation of NG2 proteoglycan by ERK and PKC{alpha} helps balance cell proliferation and migration.
I. T. Makagiansar, S. Williams, T. Mustelin, and W. B. Stallcup (2007)
J. Cell Biol. 178, 155-165
   Abstract »    Full Text »    PDF »
Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress.
C.-H. Teng, W.-N. Huang, and T.-C. Meng (2007)
J. Biol. Chem. 282, 28395-28407
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinases in Heart Development and Diseases.
Y. Wang (2007)
Circulation 116, 1413-1423
   Abstract »    Full Text »    PDF »
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
J. M. Murphy, D. M. Korzhnev, D. F. Ceccarelli, D. J. Briant, A. Zarrine-Afsar, F. Sicheri, L. E. Kay, and T. Pawson (2007)
PNAS 104, 14336-14341
   Abstract »    Full Text »    PDF »
Exploring sequence-structure relationships in the tyrosine kinome space: functional classification of the binding specificity mechanisms for cancer therapeutics.
G. M. Verkhivker (2007)
Bioinformatics 23, 1919-1926
   Abstract »    Full Text »    PDF »
From the Cover: Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
N. Scherr, S. Honnappa, G. Kunz, P. Mueller, R. Jayachandran, F. Winkler, J. Pieters, and M. O. Steinmetz (2007)
PNAS 104, 12151-12156
   Abstract »    Full Text »    PDF »
KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns.
Y.-H. Wong, T.-Y. Lee, H.-K. Liang, C.-M. Huang, T.-Y. Wang, Y.-H. Yang, C.-H. Chu, H.-D. Huang, M.-T. Ko, and J.-K. Hwang (2007)
Nucleic Acids Res. 35, W588-W594
   Abstract »    Full Text »    PDF »
CCR Drug Updates: Sorafenib and Sunitinib in Renal Cell Carcinoma.
M. N. Stein and K. T. Flaherty (2007)
Clin. Cancer Res. 13, 3765-3770
   Full Text »    PDF »
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
T.-l. Gu, T. Mercher, J. W. Tyner, V. L. Goss, D. K. Walters, M. G. Cornejo, C. Reeves, L. Popova, K. Lee, M. C. Heinrich, et al. (2007)
Blood 110, 323-333
   Abstract »    Full Text »    PDF »
c-Fms Tyrosine 559 Is a Major Mediator of M-CSF-induced Proliferation of Primary Macrophages.
S. Takeshita, R. Faccio, J. Chappel, L. Zheng, X. Feng, J. D. Weber, S. L. Teitelbaum, and F. P. Ross (2007)
J. Biol. Chem. 282, 18980-18990
   Abstract »    Full Text »    PDF »
Intrinsic Fluctuations, Robustness, and Tunability in Signaling Cycles.
J. Levine, H. Y. Kueh, and L. Mirny (2007)
Biophys. J. 92, 4473-4481
   Abstract »    Full Text »    PDF »
Development of a TranscreenerTM Kinase Assay for Protein Kinase A and Demonstration of Concordance of Data with a Filter-Binding Assay Format.
K. L. Huss, P. E. Blonigen, and R. M. Campbell (2007)
J Biomol Screen 12, 578-584
   Abstract »    PDF »
Identification of ChChd3 as a Novel Substrate of the cAMP-dependent Protein Kinase (PKA) Using an Analog-sensitive Catalytic Subunit.
S. Schauble, C. C. King, M. Darshi, A. Koller, K. Shah, and S. S. Taylor (2007)
J. Biol. Chem. 282, 14952-14959
   Abstract »    Full Text »    PDF »
Cdc37 Regulation of the Kinome: When to Hold 'Em and When to Fold 'Em.
L. M. Karnitz and S. J. Felts (2007)
Sci. STKE 2007, pe22
   Abstract »    Full Text »    PDF »
An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms.
H. Y. Zou, Q. Li, J. H. Lee, M. E. Arango, S. R. McDonnell, S. Yamazaki, T. B. Koudriakova, G. Alton, J. J. Cui, P.-P. Kung, et al. (2007)
Cancer Res. 67, 4408-4417
   Abstract »    Full Text »    PDF »
Getting connected: analysis and principles of biological networks.
X. Zhu, M. Gerstein, and M. Snyder (2007)
Genes & Dev. 21, 1010-1024
   Abstract »    Full Text »    PDF »
A Network-based Analysis of Polyanion-binding Proteins Utilizing Human Protein Arrays.
N. Salamat-Miller, J. Fang, C. W. Seidel, Y. Assenov, M. Albrecht, and C. R. Middaugh (2007)
J. Biol. Chem. 282, 10153-10163
   Abstract »    Full Text »    PDF »
The Serine/Threonine/Tyrosine Phosphoproteome of the Model Bacterium Bacillus subtilis.
B. Macek, I. Mijakovic, J. V. Olsen, F. Gnad, C. Kumar, P. R. Jensen, and M. Mann (2007)
Mol. Cell. Proteomics 6, 697-707
   Abstract »    Full Text »    PDF »
Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca2+ Sensitivity in Ventricular Myocytes.
F. Cuello, S. C. Bardswell, R. S. Haworth, X. Yin, S. Lutz, T. Wieland, M. Mayr, J. C. Kentish, and M. Avkiran (2007)
Circ. Res. 100, 864-873
   Abstract »    Full Text »    PDF »
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain.
P. Douglas, X. Cui, W. D. Block, Y. Yu, S. Gupta, Q. Ding, R. Ye, N. Morrice, S. P. Lees-Miller, and K. Meek (2007)
Mol. Cell. Biol. 27, 1581-1591
   Abstract »    Full Text »    PDF »
Proteomics Analysis of Protein Kinases by Target Class-selective Prefractionation and Tandem Mass Spectrometry.
J. Wissing, L. Jansch, M. Nimtz, G. Dieterich, R. Hornberger, G. Keri, J. Wehland, and H. Daub (2007)
Mol. Cell. Proteomics 6, 537-547
   Abstract »    Full Text »    PDF »
The Alliance for Cellular Signaling Plasmid Collection: A Flexible Resource for Protein Localization Studies and Signaling Pathway Analysis.
J. R. Zavzavadjian, S. Couture, W. S. Park, J. Whalen, S. Lyon, G. Lee, E. Fung, Q. Mi, J. Liu, E. Wall, et al. (2007)
Mol. Cell. Proteomics 6, 413-424
   Abstract »    Full Text »    PDF »
Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
A. Kuglstatter, A. G. Villasenor, D. Shaw, S. W. Lee, S. Tsing, L. Niu, K. W. Song, J. W. Barnett, and M. F. Browner (2007)
J. Immunol. 178, 2641-2645
   Abstract »    Full Text »    PDF »
Molecular basis for specificity in the druggable kinome: sequence-based analysis.
J. Chen, X. Zhang, and A. Fernandez (2007)
Bioinformatics 23, 563-572
   Abstract »    Full Text »    PDF »
Derepression of pathological cardiac genes by members of the CaM kinase superfamily.
T. A. McKinsey (2007)
Cardiovasc Res 73, 667-677
   Abstract »    Full Text »    PDF »
Meeting Report: Targeting the Kinome--20 Years of Tyrosine Kinase Inhibitor Research in Basel.
L. Bozulic, P. J. Morin, T. Hunter, and B. A. Hemmings (2007)
Sci. STKE 2007, pe8
   Abstract »    Full Text »    PDF »
TFE3 Fusions Activate MET Signaling by Transcriptional Up-regulation, Defining Another Class of Tumors as Candidates for Therapeutic MET Inhibition.
M. Tsuda, I. J. Davis, P. Argani, N. Shukla, G. G. McGill, M. Nagai, T. Saito, M. Lae, D. E. Fisher, and M. Ladanyi (2007)
Cancer Res. 67, 919-929
   Abstract »    Full Text »    PDF »
Synthesis and Characterization of 5'-p-fluorosulfonylbenzoyl-2' (or 3')-(biotinyl)adenosine as an Activity-Based Probe for Protein Kinases.
S. J. Ratcliffe, T. Yi, and S. S. Khandekar (2007)
J Biomol Screen 12, 126-132
   Abstract »    PDF »
The Rice Kinase Database. A Phylogenomic Database for the Rice Kinome.
C. Dardick, J. Chen, T. Richter, S. Ouyang, and P. Ronald (2007)
Plant Physiology 143, 579-586
   Abstract »    Full Text »    PDF »
Large-scale phosphorylation analysis of mouse liver.
J. Villen, S. A. Beausoleil, S. A. Gerber, and S. P. Gygi (2007)
PNAS 104, 1488-1493
   Abstract »    Full Text »    PDF »
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
N. Kannan, N. Haste, S. S. Taylor, and A. F. Neuwald (2007)
PNAS 104, 1272-1277
   Abstract »    Full Text »    PDF »
Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system.
N. Fulop, R. B. Marchase, and J. C. Chatham (2007)
Cardiovasc Res 73, 288-297
   Abstract »    Full Text »    PDF »
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1.
V. H. Bustos, A. Ferrarese, A. Venerando, O. Marin, J. E. Allende, and L. A. Pinna (2006)
PNAS 103, 19725-19730
   Abstract »    Full Text »    PDF »
Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia.
J. W.P.M. van Baal, S. H. Diks, R. J.A. Wanders, A. M. Rygiel, F. Milano, J. Joore, J. J.G.H.M. Bergman, M. P. Peppelenbosch, and K. K. Krishnadath (2006)
Cancer Res. 66, 11605-11612
   Abstract »    Full Text »    PDF »
Inhibition of Cell Migration by Autophosphorylated Mammalian Sterile 20-Like Kinase 3 (MST3) Involves Paxillin and Protein-tyrosine Phosphatase-PEST.
T.-J. Lu, W.-Y. Lai, C.-Y. F. Huang, W.-J. Hsieh, J.-S. Yu, Y.-J. Hsieh, W.-T. Chang, T.-H. Leu, W.-C. Chang, W.-J. Chuang, et al. (2006)
J. Biol. Chem. 281, 38405-38417
   Abstract »    Full Text »    PDF »
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases.
M. A. Bogoyevitch and B. Kobe (2006)
Microbiol. Mol. Biol. Rev. 70, 1061-1095
   Abstract »    Full Text »    PDF »
A Microfluidics-Based Mobility Shift Assay to Discover New Tyrosine Phosphatase Inhibitors.
D. Perrin, C. Fremaux, D. Besson, W. H. Sauer, and A. Scheer (2006)
J Biomol Screen 11, 996-1004
   Abstract »    PDF »
Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885.