Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,*Razvan Lapadat
Multicellular organisms have three well-characterized subfamilies
of mitogen-activated protein kinases (MAPKs) that controla vast array
of physiological processes. These enzymes are regulatedby a
characteristic phosphorelay system in which a series of threeprotein
kinases phosphorylate and activate one another. The extracellularsignal-regulated kinases (ERKs) function in the control of celldivision, and inhibitors of these enzymes are being explored asanticancer agents. The c-Jun amino-terminal kinases
(JNKs) arecritical regulators of transcription, and JNK
inhibitors may beeffective in control of rheumatoid arthritis. The p38
MAPKs areactivated by inflammatory cytokines and environmental
stressesand may contribute to diseases like asthma and autoimmunity.
Department of Pharmacology, University of Colorado Health Sciences
Center, Denver, CO 80262, USA.
*
To whom correspondence should be addressed. E-mail:
gary.johnson{at}uchsc.edu
Gary L. Johnson Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10958 |Canonical Pathway »
DATABASE OF CELL SIGNALING
ERK1/ERK2 MAPK Pathway
Gary L. Johnson Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10705 |Canonical Pathway »
DATABASE OF CELL SIGNALING
JNK MAPK Pathway
Gary L. Johnson Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10827 |Canonical Pathway »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
AMP-activated protein kinase facilitates avian reovirus to induce mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 3/6 signalling that is beneficial for virus replication.
W. T. Ji, L. H. Lee, F. L. Lin, L. Wang, and H. J. Liu (2009)
J. Gen. Virol.
90, 3002-3009
|Abstract »|Full Text »|PDF »
Cyclin D1 Induction by Benzo[a]pyrene-7,8-diol-9,10-epoxide via the Phosphatidylinositol 3-Kinase/Akt/MAPK- and p70s6k-dependent Pathway Promotes Cell Transformation and Tumorigenesis.
J. Ding, B. Ning, W. Gong, W. Wen, K. Wu, J. Liang, G. He, S. Huang, W. Sun, T. Han, et al. (2009)
J. Biol. Chem.
284, 33311-33319
|Abstract »|Full Text »|PDF »
A Novel Role of Interleukin-13 Receptor {alpha}2 in Pancreatic Cancer Invasion and Metastasis.
T. Fujisawa, B. Joshi, A. Nakajima, and R. K. Puri (2009)
Cancer Res.
69, 8678-8685
|Abstract »|Full Text »|PDF »
Ethanol Augments RANTES/CCL5 Expression in Rat Liver Sinusoidal Endothelial Cells and Human Endothelial Cells via Activation of NF-{kappa}B, HIF-1{alpha}, and AP-1.
S. M. Yeligar, K. Machida, H. Tsukamoto, and V. K. Kalra (2009)
J. Immunol.
183, 5964-5976
|Abstract »|Full Text »|PDF »
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors.
C. R. Geest, M. Buitenhuis, M. J. A. Groot Koerkamp, F. C. P. Holstege, E. Vellenga, and P. J. Coffer (2009)
Blood
114, 3402-3412
|Abstract »|Full Text »|PDF »
M.-L. Sung, C.-C. Wu, H.-I Chang, C.-K. Yen, H. J. Chen, J.-C. Cheng, S. Chien, and C.-N. Chen (2009)
Circ. Res.
105, 755-763
|Abstract »|Full Text »|PDF »
Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.
T. Kawakami, R. Inagi, H. Takano, S. Sato, J. R. Ingelfinger, T. Fujita, and M. Nangaku (2009)
Nephrol. Dial. Transplant.
24, 2665-2672
|Abstract »|Full Text »|PDF »
The p38 Mitogen-Activated Protein Kinase Regulates 11{beta}-Hydroxysteroid Dehydrogenase Type 2 (11{beta}-HSD2) Expression in Human Trophoblast Cells through Modulation of 11{beta}-HSD2 Messenger Ribonucleic Acid Stability.
MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.
E. J. Carter, R. A. Cosgrove, I. Gonzalez, J. H. Eisemann, F. A. Lovett, L. J. Cobb, and J. M. Pell (2009)
J. Cell Sci.
122, 3104-3112
|Abstract »|Full Text »|PDF »
Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation.
S. Uchida, K. Yoshioka, R. Kizu, H. Nakagama, T. Matsunaga, Y. Ishizaka, R. Y.C. Poon, and K. Yamashita (2009)
Cancer Res.
69, 6438-6444
|Abstract »|Full Text »|PDF »
Remodeling of Global Transcription Patterns of Cryptococcus neoformans Genes Mediated by the Stress-Activated HOG Signaling Pathways.
Y.-J. Ko, Y. M. Yu, G.-B. Kim, G.-W. Lee, P. J. Maeng, S. Kim, A. Floyd, J. Heitman, and Y.-S. Bahn (2009)
Eukaryot. Cell
8, 1197-1217
|Abstract »|Full Text »|PDF »
Anti-inflammatory Action of Pterostilbene Is Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells.
S. Paul, A. M. Rimando, H. J. Lee, Y. Ji, B. S. Reddy, and N. Suh (2009)
Cancer Prevention Research
2, 650-657
|Abstract »|Full Text »|PDF »
Bronchial Airway Epithelial Cell Damage Following Exposure to Cigarette Smoke Includes Disassembly of Tight Junction Components Mediated by the Extracellular Signal-Regulated Kinase 1/2 Pathway.
L. Petecchia, F. Sabatini, L. Varesio, A. Camoirano, C. Usai, A. Pezzolo, and G. A. Rossi (2009)
Chest
135, 1502-1512
|Abstract »|Full Text »|PDF »
GnRH signaling in intrauterine tissues.
H.-M. Wu, H.-S. Wang, H.-Y. Huang, Y.-K. Soong, C. D MacCalman, and P. C K Leung (2009)
Reproduction
137, 769-777
|Abstract »|Full Text »|PDF »
A Double Hit to Kill Tumor and Endothelial Cells by TRAIL and Antiangiogenic 3TSR.
B. Ren, K. Song, S. Parangi, T. Jin, M. Ye, R. Humphreys, M. Duquette, X. Zhang, N. Benhaga, J. Lawler, et al. (2009)
Cancer Res.
69, 3856-3865
|Abstract »|Full Text »|PDF »
p38{alpha} and p38{gamma} Mediate Oncogenic ras-induced Senescence through Differential Mechanisms.
J. Kwong, L. Hong, R. Liao, Q. Deng, J. Han, and P. Sun (2009)
J. Biol. Chem.
284, 11237-11246
|Abstract »|Full Text »|PDF »
Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling but Not in Physiological Cardiac Growth.
W. Liu, M. Zi, J. Jin, S. Prehar, D. Oceandy, T. E. Kimura, M. Lei, L. Neyses, A. H. Weston, E. J. Cartwright, et al. (2009)
Circ. Res.
104, 905-914
|Abstract »|Full Text »|PDF »
Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling.
D. Brown, A. P S. Hikim, E. L Kovacheva, and I. Sinha-Hikim (2009)
J. Endocrinol.
201, 129-139
|Abstract »|Full Text »|PDF »
p38 MAP kinase inhibitor reverses stress-induced myocardial dysfunction in vivo.
F. Chen, H. Kan, G. Hobbs, and M. S. Finkel (2009)
J Appl Physiol
106, 1132-1141
|Abstract »|Full Text »|PDF »
Mitogen-Activated Protein Kinase Signaling in Male Germ Cell Apoptosis in the Rat.
Y. Jia, J. Castellanos, C. Wang, I. Sinha-Hikim, Y. Lue, R. S. Swerdloff, and A. P. Sinha-Hikim (2009)
Biol Reprod
80, 771-780
|Abstract »|Full Text »|PDF »
The Human SPT20-Containing SAGA Complex Plays a Direct Role in the Regulation of Endoplasmic Reticulum Stress-Induced Genes.
Z. Nagy, A. Riss, C. Romier, X. le Guezennec, A. R. Dongre, M. Orpinell, J. Han, H. Stunnenberg, and L. Tora (2009)
Mol. Cell. Biol.
29, 1649-1660
|Abstract »|Full Text »|PDF »
MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival.
X. Wang, X. Chang, V. Facchinetti, Y. Zhuang, and B. Su (2009)
J. Immunol.
182, 3597-3608
|Abstract »|Full Text »|PDF »
Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation.
A. Jurek, K. Amagasaki, A. Gembarska, C.-H. Heldin, and J. Lennartsson (2009)
J. Biol. Chem.
284, 4626-4634
|Abstract »|Full Text »|PDF »
The Serum Response Factor and a Putative Novel Transcription Factor Regulate Expression of the Immediate-Early Gene Arc/Arg3.1 in Neurons.
S. A. Pintchovski, C. L. Peebles, H. Joo Kim, E. Verdin, and S. Finkbeiner (2009)
J. Neurosci.
29, 1525-1537
|Abstract »|Full Text »|PDF »
Transducing Neuronal Activity into Dendritic Spine Morphology: New Roles for p38 MAP Kinase and N-cadherin.
H. Sugiura, H. Tanaka, S. Yasuda, T. Takemiya, and K. Yamagata (2009)
Neuroscientist
15, 90-104
|Abstract »|PDF »
Histone H3 as a novel substrate for MAP kinase phosphatase-1.
C. M. Kinney, U. M. Chandrasekharan, L. Yang, J. Shen, M. Kinter, M. S. McDermott, and P. E. DiCorleto (2009)
Am J Physiol Cell Physiol
296, C242-C249
|Abstract »|Full Text »|PDF »
Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation.
A Novel Mitogen-Activated Protein Kinase Phosphatase-1 and Glucocorticoid Receptor (GR) Interacting Protein-1-Dependent Combinatorial Mechanism of Gene Transrepression by GR.
Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal Kinase.
N. Gao, A. Budhraja, S. Cheng, H. Yao, Z. Zhang, and X. Shi (2009)
Clin. Cancer Res.
15, 140-149
|Abstract »|Full Text »|PDF »
Constitutive Activity of JNK2{alpha}2 Is Dependent on a Unique Mechanism of MAPK Activation.
R. T. Nitta, A. H. Chu, and A. J. Wong (2008)
J. Biol. Chem.
283, 34935-34945
|Abstract »|Full Text »|PDF »
Arsenic Trioxide (As2O3) Inhibits Expression of Estrogen Receptor--alpha Through Regulation of the Mitogen-activated Protein Kinase (MAPK) Pathway in Endometrial Cancer Cells.
V. L. Bae-Jump, Chunxiao Zhou, J. F. Boggess, and P. A. Gehrig (2008)
Reproductive Sciences
15, 1011-1017
|Abstract »|PDF »
The Fas System Confers Protection against Alveolar Disruption in Hyperoxia-Exposed Newborn Mice.
Q. Mao, S. Gundavarapu, C. Patel, A. Tsai, F. I. Luks, and M. E. De Paepe (2008)
Am. J. Respir. Cell Mol. Biol.
39, 717-729
|Abstract »|Full Text »|PDF »
c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/{beta}-catenin signaling through GSK3{beta} pathway.
D. Hu, W. Fang, A. Han, L. Gallagher, R. J. Davis, B. Xiong, and W. Yang (2008)
Carcinogenesis
29, 2317-2324
|Abstract »|Full Text »|PDF »
Lidocaine Inhibits NIH-3T3 Cell Multiplication by Increasing the Expression of Cyclin-Dependent Kinase Inhibitor 1A (p21).
S. P. Desai, K. Kojima, C. A. Vacanti, and S. Kodama (2008)
Anesth. Analg.
107, 1592-1597
|Abstract »|Full Text »|PDF »
Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos.
D. Subramaniam, P. Giridharan, N. Murmu, N. P. Shankaranarayanan, R. May, C. W. Houchen, R. P. Ramanujam, A. Balakrishnan, R. A. Vishwakarma, and S. Anant (2008)
Cancer Res.
68, 8573-8581
|Abstract »|Full Text »|PDF »
The Type 1 Insulin-Like Growth Factor Receptor Pathway.
M. M. Chitnis, J. S.P. Yuen, A. S. Protheroe, M. Pollak, and V. M. Macaulay (2008)
Clin. Cancer Res.
14, 6364-6370
|Abstract »|Full Text »|PDF »
Activation of the RAF/Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Mediates Apoptosis Induced by Chelerythrine in Osteosarcoma.
R. Yang, S. Piperdi, and R. Gorlick (2008)
Clin. Cancer Res.
14, 6396-6404
|Abstract »|Full Text »|PDF »
C3a-derived peptide binds to the type I Fc{varepsilon}R and inhibits proximal-coupling signal processes and cytokine secretion by mast cells.
H. Peterfy, G. Toth, I. Pecht, and A. Erdei (2008)
Int. Immunol.
20, 1239-1245
|Abstract »|Full Text »|PDF »
Serum Amyloid A Induces CCL2 Production via Formyl Peptide Receptor-Like 1-Mediated Signaling in Human Monocytes.
H. Y. Lee, S. D. Kim, J. W. Shim, S. Y. Lee, H. Lee, K.-H. Cho, J. Yun, and Y.-S. Bae (2008)
J. Immunol.
181, 4332-4339
|Abstract »|Full Text »|PDF »
Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil.
H.-Y. Zhao, A. Ooyama, M. Yamamoto, R. Ikeda, M. Haraguchi, S. Tabata, T. Furukawa, X.-F. Che, S. Zhang, T. Oka, et al. (2008)
Cancer Res.
68, 7035-7041
|Abstract »|Full Text »|PDF »
Extracellularly Signal-Regulated Kinase Activity in the Human Endometrium: Possible Roles in the Pathogenesis of Endometriosis.
W. Murk, C. S. Atabekoglu, H. Cakmak, A. Heper, A. Ensari, U. A. Kayisli, and A. Arici (2008)
J. Clin. Endocrinol. Metab.
93, 3532-3540
|Abstract »|Full Text »|PDF »
Rap1b Regulates B Cell Development, Homing, and T Cell-Dependent Humoral Immunity.
H. Chu, A. Awasthi, G. C. White II, M. Chrzanowska-Wodnicka, and S. Malarkannan (2008)
J. Immunol.
181, 3373-3383
|Abstract »|Full Text »|PDF »
Steroidogenic Factor 1 Regulates Expression of the Cannabinoid Receptor 1 in the Ventromedial Hypothalamic Nucleus.
K. W. Kim, Y.-H. Jo, L. Zhao, N. R. Stallings, S. C. Chua Jr, and K. L. Parker (2008)
Mol. Endocrinol.
22, 1950-1961
|Abstract »|Full Text »|PDF »
In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury.
Y. Zhang, X.-T. Bai, K.-Y. Zhu, Y. Jin, M. Deng, H.-Y. Le, Y.-F. Fu, Y. Chen, J. Zhu, A. T. Look, et al. (2008)
J. Immunol.
181, 2155-2164
|Abstract »|Full Text »|PDF »
Mitogen-activated Protein Kinase Phosphatase-1 Represses c-Jun NH2-terminal Kinase-mediated Apoptosis via NF-{kappa}B Regulation.
Z. Wang, N. Cao, D. Nantajit, M. Fan, Y. Liu, and J. J. Li (2008)
J. Biol. Chem.
283, 21011-21023
|Abstract »|Full Text »|PDF »
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90.
Y. Kuwano, H. H. Kim, K. Abdelmohsen, R. Pullmann Jr., J. L. Martindale, X. Yang, and M. Gorospe (2008)
Mol. Cell. Biol.
28, 4562-4575
|Abstract »|Full Text »|PDF »
PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059.
3{beta}-Hydroxysteroid-{Delta}24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis.
X. Lu, F. Kambe, X. Cao, Y. Kozaki, T. Kaji, T. Ishii, and H. Seo (2008)
Endocrinology
149, 3267-3273
|Abstract »|Full Text »|PDF »
Renal Ischemia: Does Sex Matter?.
M. P. Hutchens, J. Dunlap, P. D. Hurn, and P. O. Jarnberg (2008)
Anesth. Analg.
107, 239-249
|Abstract »|Full Text »|PDF »
MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and Nuclear Factor-{kappa}B Activation in Human Pancreatic Islet Cells.
Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells.
K. Chmura, X. Bai, M. Nakamura, P. Kandasamy, M. McGibney, K. Kuronuma, H. Mitsuzawa, D. R. Voelker, and E. D. Chan (2008)
Am J Physiol Lung Cell Mol Physiol
295, L220-L230
|Abstract »|Full Text »|PDF »
The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death.
T-cell Development and Function Are Modulated by Dual Specificity Phosphatase DUSP5.
P. E. Kovanen, J. Bernard, A. Al-Shami, C. Liu, J. Bollenbacher-Reilley, L. Young, C. Pise-Masison, R. Spolski, and W. J. Leonard (2008)
J. Biol. Chem.
283, 17362-17369
|Abstract »|Full Text »|PDF »
Protoapigenone, a Novel Flavonoid, Induces Apoptosis in Human Prostate Cancer Cells through Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase 1/2.
H.-L. Chang, Y.-C. Wu, J.-H. Su, Y.-T. Yeh, and S.-S. F. Yuan (2008)
J. Pharmacol. Exp. Ther.
325, 841-849
|Abstract »|Full Text »|PDF »
Gonadotropin Stimulation of Ovarian Fractalkine Expression and Fractalkine Augmentation of Progesterone Biosynthesis by Luteinizing Granulosa Cells.
P. Zhao, A. De, Z. Hu, J. Li, S. M. Mulders, M. D. Sollewijn Gelpke, E.-K. Duan, and A. J. W. Hsueh (2008)
Endocrinology
149, 2782-2789
|Abstract »|Full Text »|PDF »
The MAPK Kinase Kinase-1 Is Essential for Stress-Induced Pancreatic Islet Cell Death.
D. Mokhtari, J. W. Myers, and N. Welsh (2008)
Endocrinology
149, 3046-3053
|Abstract »|Full Text »|PDF »
Sequential Protein Kinase C (PKC)-dependent and PKC-independent Protein Kinase D Catalytic Activation via Gq-coupled Receptors: DIFFERENTIAL REGULATION OF ACTIVATION LOOP SER744 AND SER748 PHOSPHORYLATION.
R. Jacamo, J. Sinnett-Smith, O. Rey, R. T. Waldron, and E. Rozengurt (2008)
J. Biol. Chem.
283, 12877-12887
|Abstract »|Full Text »|PDF »
The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells.
Non-canonical fibroblast growth factor signalling in angiogenesis.
M. Murakami, A. Elfenbein, and M. Simons (2008)
Cardiovasc Res
78, 223-231
|Abstract »|Full Text »|PDF »
Mechanism of Action of l-CDB-4022, a Potential Nonhormonal Male Contraceptive, in the Seminiferous Epithelium of the Rat Testis.
S. Koduri, S. A. Hild, L. Pessaint, J. R. Reel, and B. J. Attardi (2008)
Endocrinology
149, 1850-1860
|Abstract »|Full Text »|PDF »
Cadmium-Induced Germline Apoptosis in Caenorhabditis elegans: The Roles of HUS1, p53, and MAPK Signaling Pathways.
S. Wang, M. Tang, B. Pei, X. Xiao, J. Wang, H. Hang, and L. Wu (2008)
Toxicol. Sci.
102, 345-351
|Abstract »|Full Text »|PDF »
MAPKs and their relevance to arthritis and inflammation.
T. Thalhamer, M. A. McGrath, and M. M. Harnett (2008)
Rheumatology
47, 409-414
|Abstract »|Full Text »|PDF »
Novel Pro-survival Functions of the Kruppel-like Transcription Factor Egr2 in Promotion of Macrophage Colony-stimulating Factor-mediated Osteoclast Survival Downstream of the MEK/ERK Pathway.
E. W. Bradley, M. M. Ruan, and M. J. Oursler (2008)
J. Biol. Chem.
283, 8055-8064
|Abstract »|Full Text »|PDF »
Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells.
M. Handfield, H.V. Baker, and R.J. Lamont (2008)
Journal of Dental Research
87, 203-223
|Abstract »|Full Text »|PDF »
Altered TAB1:I{kappa}B Kinase Interaction Promotes Transforming Growth Factor {beta}-Mediated Nuclear Factor-{kappa}B Activation during Breast Cancer Progression.
Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by Picropodophyllin.
R. Vasilcanu, D. Vasilcanu, B. Sehat, S. Yin, A. Girnita, M. Axelson, and L. Girnita (2008)
Mol. Pharmacol.
73, 930-939
|Abstract »|Full Text »|PDF »
Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process.
T. Kawasaki, M. A. Choudhry, M. G. Schwacha, S. Fujimi, J. A. Lederer, K. I. Bland, and I. H. Chaudry (2008)
Am J Physiol Cell Physiol
294, C754-C764
|Abstract »|Full Text »|PDF »
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1.
A. Blagoveshchenskaya, F. Y. Cheong, H. M. Rohde, G. Glover, A. Knodler, T. Nicolson, G. Boehmelt, and P. Mayinger (2008)
J. Cell Biol.
180, 803-812
|Abstract »|Full Text »|PDF »
Effects of KGF on Alveolar Epithelial Cell Transdifferentiation Are Mediated by JNK Signaling.
R. Qiao, W. Yan, C. Clavijo, R. Mehrian-Shai, Q. Zhong, K.-J. Kim, D. Ann, E. D. Crandall, and Z. Borok (2008)
Am. J. Respir. Cell Mol. Biol.
38, 239-246
|Abstract »|Full Text »|PDF »
Important role of p38 MAP kinase/NF-{kappa}B signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype.
M. Yang, J. Wu, C. M. Martin, P. R. Kvietys, and T. Rui (2008)
Am J Physiol Heart Circ Physiol
294, H994-H1001
|Abstract »|Full Text »|PDF »
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.
D. de Totero, R. Meazza, M. Capaia, M. Fabbi, B. Azzarone, E. Balleari, M. Gobbi, G. Cutrona, M. Ferrarini, and S. Ferrini (2008)
Blood
111, 517-524
|Abstract »|Full Text »|PDF »
Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo.
D. Huang, Y. Ding, W.-M. Luo, S. Bender, C.-N. Qian, E. Kort, Z.-F. Zhang, K. VandenBeldt, N. S. Duesbery, J. H. Resau, et al. (2008)
Cancer Res.
68, 81-88
|Abstract »|Full Text »|PDF »
Different Mitogen-Activated Protein Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage.
S. J. Tudhope, T. K. Finney-Hayward, A. G. Nicholson, R. J. Mayer, M. S. Barnette, P. J. Barnes, and L. E. Donnelly (2008)
J. Pharmacol. Exp. Ther.
324, 306-312
|Abstract »|Full Text »|PDF »
ERK-Dependent MKP-1 Mediated Cisplatin Resistance in Human Ovarian Cancer Cells.
Activation of a C-terminal Transcriptional Activation Domain of ERK5 by Autophosphorylation.
H. Morimoto, K. Kondoh, S. Nishimoto, K. Terasawa, and E. Nishida (2007)
J. Biol. Chem.
282, 35449-35456
|Abstract »|Full Text »|PDF »
Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.
M. Nakamura, B. Han, T. Nishishita, Y. Bai, and K. Kakudo (2007)
J. Mol. Endocrinol.
39, 375-384
|Abstract »|Full Text »|PDF »
Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity.
C. M. Danson, S. M. Pocha, G. B. Bloomberg, and G. O. Cory (2007)
J. Cell Sci.
120, 4144-4154
|Abstract »|Full Text »|PDF »
Ssk2 Mitogen-Activated Protein Kinase Kinase Kinase Governs Divergent Patterns of the Stress-Activated Hog1 Signaling Pathway in Cryptococcus neoformans.
Y.-S. Bahn, S. Geunes-Boyer, and J. Heitman (2007)
Eukaryot. Cell
6, 2278-2289
|Abstract »|Full Text »|PDF »
C/EBP phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin.
Phosphatidylinositol Ether Lipid Analogues That Inhibit AKT Also Independently Activate the Stress Kinase, p38{alpha}, through MKK3/6-independent and -dependent Mechanisms.
J. J. Gills, S. S. Castillo, C. Zhang, P. A. Petukhov, R. M. Memmott, M. Hollingshead, N. Warfel, J. Han, A. P. Kozikowski, and P. A. Dennis (2007)
J. Biol. Chem.
282, 27020-27029
|Abstract »|Full Text »|PDF »
Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.
L. Cong, J. Gasser, J. Zhao, B. Yang, F. Li, and A. Z Zhao (2007)
Endocr. Relat. Cancer
14, 713-720
|Abstract »|Full Text »|PDF »
Moraxella catarrhalis induces ERK- and NF-{kappa}B-dependent COX-2 and prostaglandin E2 in lung epithelium.
P. D. N'Guessan, B. Temmesfeld-Wollbruck, J. Zahlten, J. Eitel, S. Zabel, B. Schmeck, B. Opitz, S. Hippenstiel, N. Suttorp, and H. Slevogt (2007)
Eur. Respir. J.
30, 443-451
|Abstract »|Full Text »|PDF »
Role of MAPK Phosphatase-1 in the Induction of Monocyte Chemoattractant Protein-1 during the Course of Adipocyte Hypertrophy.
A. Ito, T. Suganami, Y. Miyamoto, Y. Yoshimasa, M. Takeya, Y. Kamei, and Y. Ogawa (2007)
J. Biol. Chem.
282, 25445-25452
|Abstract »|Full Text »|PDF »
G Protein beta{gamma} Subunits Augment UVB-induced Apoptosis by Stimulating the Release of Soluble Heparin-binding Epidermal Growth Factor from Human Keratinocytes.
M. Seo, M.-J. Lee, J. H. Heo, Y.-I. Lee, Y. Kim, S.-Y. Kim, E.-S. Lee, and Y.-S. Juhnn (2007)
J. Biol. Chem.
282, 24720-24730
|Abstract »|Full Text »|PDF »
Lysophosphatidic Acid Regulates Trafficking of beta2-Adrenergic Receptors: THE G{alpha}13/p115RhoGEF/JNK PATHWAY STIMULATES RECEPTOR INTERNALIZATION.
E. Shumay, J. Tao, H.-y. Wang, and C. C. Malbon (2007)
J. Biol. Chem.
282, 21529-21541
|Abstract »|Full Text »|PDF »
