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Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense
Ilhem Messaoudi,12Jose A. Guevara Patiño,2Ruben Dyall,2*Joël LeMaoult,2*Janko Nikolich-ugich12
Major histocompatibility complex (mhc)-encoded
molecules govern immune responses by presenting antigenic peptides to T
cells.The extensive polymorphism of genes encoding these molecules isbelieved to enhance immune defense by broadening the array ofantigenic
peptides available for T cell recognition, but directevidence
supporting the importance of this mechanism in combatingpathogens is
limited. Here we link mhc polymorphism-driven
diversificationof the cytotoxic T lymphocyte (CTL) repertoire to the
generationof high-avidity, protective antiviral T cells and to
superiorantiviral defense. Thus, much of the beneficial effect of themhc polymorphism in immune defense may be due to its
criticalinfluence on the properties of the selected CTL repertoire.
1 Vaccine and Gene Therapy Institute and the
Oregon National Primate Research Center, Oregon Health & Science
University, Beaverton, OR 97006, USA.
2 Immunology
Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
*
Present addresses of these authors, contact J.N.-.
To whom correspondence should be addressed. E-mail:
nikolich{at}ohsu.edu.
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ugich, J.
