Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling - Call For Papers

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 November 2002:
Vol. 298. no. 5596, pp. 1248 - 1251
DOI: 10.1126/science.1072699
Prev | Table of Contents

Reports

Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex

Tommaso Pizzorusso,12* Paolo Medini,1 Nicoletta Berardi,24 Sabrina Chierzi,3 James W. Fawcett,3 Lamberto Maffei12

In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.

1 Scuola Normale Superiore, 56100 Pisa, Italy.
2 Istituto di Neuroscienze, Consiglio Nazionale Ricerche, via Moruzzi 1, 56100 Pisa, Italy.
3 Cambridge University Centre for Brain Repair, Robinson Way, Cambridge CB2 2PY, UK.
4 Dipartimento di Psicologia, Università di Firenze, 50123 Firenze, Italy.
*   To whom correspondence should be addressed. E-mail: tommaso{at}in.pi.cnr.it

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spatiotemporal expression of chondroitin sulfate sulfotransferases in the postnatal developing mouse cerebellum.
M. Ishii and N. Maeda (2008)
Glycobiology 18, 602-614
   Abstract »    Full Text »    PDF »
Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation.
(2008)
PNAS 105, 9409-9414
Reduction of Brain Injury in Neonatal Hypoxic--Ischemic Rats by Intracerebroventricular Injection of Neural Stem/Progenitor Cells Together With Chondroitinase ABC.
Y. Sato, K. Nakanishi, M. Hayakawa, H. Kakizawa, A. Saito, Y. Kuroda, M. Ida, Y. Tokita, S. Aono, F. Matsui, et al. (2008)
Reproductive Sciences 15, 613-620
   Abstract »    PDF »
Plasticity of Representational Maps in Somatosensory Cortex Observed by In Vivo Voltage-Sensitive Dye Imaging.
D. J. Wallace and B. Sakmann (2008)
Cereb Cortex 18, 1361-1373
   Abstract »    Full Text »    PDF »
Expression and Function of the HNK-1 Carbohydrate.
I. Morita, Y. Kizuka, S. Kakuda, and S. Oka (2008)
J. Biochem. 143, 719-724
   Abstract »    Full Text »    PDF »
Chondroitin Sulfate Proteoglycans and Microglia Prevent Migration and Integration of Grafted Muller Stem Cells into Degenerating Retina.
S. Singhal, J. M. Lawrence, B. Bhatia, J. S. Ellis, A. S. Kwan, A. MacNeil, P. J. Luthert, J. W. Fawcett, M.-T. Perez, P. T. Khaw, et al. (2008)
Stem Cells 26, 1074-1082
   Abstract »    Full Text »    PDF »
Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch.
S. T. Carmichael (2008)
Stroke 39, 1380-1388
   Abstract »    Full Text »    PDF »
Inhibiting Glycosaminoglycan Chain Polymerization Decreases the Inhibitory Activity of Astrocyte-Derived Chondroitin Sulfate Proteoglycans.
T. L. Laabs, H. Wang, Y. Katagiri, T. McCann, J. W. Fawcett, and H. M. Geller (2007)
J. Neurosci. 27, 14494-14501
   Abstract »    Full Text »    PDF »
Repair in the central nervous system.
J. FitzGerald and J. Fawcett (2007)
J Bone Joint Surg Br 89-B, 1413-1420
   Abstract »    Full Text »    PDF »
Synaptic Plasticity (and the Lack Thereof) in Hippocampal CA2 Neurons.
M. Zhao, Y.-S. Choi, K. Obrietan, and S. M. Dudek (2007)
J. Neurosci. 27, 12025-12032
   Abstract »    Full Text »    PDF »
Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells.
S. Sirko, A. von Holst, A. Wizenmann, M. Gotz, and A. Faissner (2007)
Development 134, 2727-2738
   Abstract »    Full Text »    PDF »
Persistence of Experience-Induced Homeostatic Synaptic Plasticity through Adulthood in Superficial Layers of Mouse Visual Cortex.
A. Goel and H.-K. Lee (2007)
J. Neurosci. 27, 6692-6700
   Abstract »    Full Text »    PDF »
Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex.
P. A. McRae, M. M. Rocco, G. Kelly, J. C. Brumberg, and R. T. Matthews (2007)
J. Neurosci. 27, 5405-5413
   Abstract »    Full Text »    PDF »
Transient Synaptic Silencing of Developing Striate Cortex Has Persistent Effects on Visual Function and Plasticity.
M. Caleo, L. Restani, L. Gianfranceschi, L. Costantin, C. Rossi, O. Rossetto, C. Montecucco, and L. Maffei (2007)
J. Neurosci. 27, 4530-4540
   Abstract »    Full Text »    PDF »
Monocular deprivation in adult mice alters visual acuity and single-unit activity.
Q. S. Fischer, A. Graves, S. Evans, M. E. Lickey, and T. A. Pham (2007)
Learn. Mem. 14, 277-286
   Abstract »    Full Text »    PDF »
Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair.
C. M. Galtrey, R. A. Asher, F. Nothias, and J. W. Fawcett (2007)
Brain 130, 926-939
   Abstract »    Full Text »    PDF »
Inosine promotes recovery of skilled motor function in a model of focal brain injury.
J. M. Smith, P. Lunga, D. Story, N. Harris, J. Le Belle, M. F James, J. D. Pickard, and J. W. Fawcett (2007)
Brain 130, 915-925
   Abstract »    Full Text »    PDF »
Critical Period Window for Spectral Tuning Defined in the Primary Auditory Cortex (A1) in the Rat.
E. de Villers-Sidani, E. F. Chang, S. Bao, and M. M. Merzenich (2007)
J. Neurosci. 27, 180-189
   Abstract »    Full Text »    PDF »
Chondroitinase ABC Promotes Sprouting of Intact and Injured Spinal Systems after Spinal Cord Injury..
A. W. Barritt, M. Davies, F. Marchand, R. Hartley, J. Grist, P. Yip, S. B. McMahon, and E. J. Bradbury (2006)
J. Neurosci. 26, 10856-10867
   Abstract »    Full Text »    PDF »
PirB Restricts Ocular-Dominance Plasticity in Visual Cortex.
J. Syken, T. GrandPre, P. O. Kanold, and C. J. Shatz (2006)
Science 313, 1795-1800
   Abstract »    Full Text »    PDF »
Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice..
I. Apostolova, A. Irintchev, and M. Schachner (2006)
J. Neurosci. 26, 7849-7859
   Abstract »    Full Text »    PDF »
Versican G3 Domain Regulates Neurite Growth and Synaptic Transmission of Hippocampal Neurons by Activation of Epidermal Growth Factor Receptor.
Y.-Y. Xiang, H. Dong, Y. Wan, J. Li, A. Yee, B. B. Yang, and W.-Y. Lu (2006)
J. Biol. Chem. 281, 19358-19368
   Abstract »    Full Text »    PDF »
Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats..
K. Iny, A. J. Heynen, E. Sklar, and M. F. Bear (2006)
J. Neurosci. 26, 7368-7374
   Abstract »    Full Text »    PDF »
Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord..
J. D. Houle, V. J. Tom, D. Mayes, G. Wagoner, N. Phillips, and J. Silver (2006)
J. Neurosci. 26, 7405-7415
   Abstract »    Full Text »    PDF »
Activity-dependent Expression of occ1 in Excitatory Neurons Is a Characteristic Feature of the Primate Visual Cortex.
T. Takahata, Y. Komatsu, A. Watakabe, T. Hashikawa, S. Tochitani, and T. Yamamori (2006)
Cereb Cortex 16, 929-940
   Abstract »    Full Text »    PDF »
Composition of Perineuronal Net Extracellular Matrix in Rat Brain: A DIFFERENT DISACCHARIDE COMPOSITION FOR THE NET-ASSOCIATED PROTEOGLYCANS.
S. S. Deepa, D. Carulli, C. Galtrey, K. Rhodes, J. Fukuda, T. Mikami, K. Sugahara, and J. W. Fawcett (2006)
J. Biol. Chem. 281, 17789-17800
   Abstract »    Full Text »    PDF »
Structural and functional recovery from early monocular deprivation in adult rats.
T. Pizzorusso, P. Medini, S. Landi, S. Baldini, N. Berardi, and L. Maffei (2006)
PNAS 103, 8517-8522
   Abstract »    Full Text »    PDF »
Genes associated with adult axon regeneration promoted by olfactory ensheathing cells: a new role for matrix metalloproteinase 2..
E. Pastrana, M. T. Moreno-Flores, E. N. Gurzov, J. Avila, F. Wandosell, and J. Diaz-Nido (2006)
J. Neurosci. 26, 5347-5359
   Abstract »    Full Text »    PDF »
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury..
J. M. Massey, C. H. Hubscher, M. R. Wagoner, J. A. Decker, J. Amps, J. Silver, and S. M. Onifer (2006)
J. Neurosci. 26, 4406-4414
   Abstract »    Full Text »    PDF »
Visual deprivation reactivates rapid ocular dominance plasticity in adult visual cortex..
H.-Y. He, W. Hodos, and E. M. Quinlan (2006)
J. Neurosci. 26, 2951-2955
   Abstract »    Full Text »    PDF »
Identification and Functions of Chondroitin Sulfate in the Milieu of Neural Stem Cells.
M. Ida, T. Shuo, K. Hirano, Y. Tokita, K. Nakanishi, F. Matsui, S. Aono, H. Fujita, Y. Fujiwara, T. Kaji, et al. (2006)
J. Biol. Chem. 281, 5982-5991
   Abstract »    Full Text »    PDF »
Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus.
S. Chakravarthy, M. H. Saiepour, M. Bence, S. Perry, R. Hartman, J. J. Couey, H. D. Mansvelder, and C. N. Levelt (2006)
PNAS 103, 1071-1076
   Abstract »    Full Text »    PDF »
Demonstration of the Pleiotrophin-binding Oligosaccharide Sequences Isolated from Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains of Embryonic Pig Brains.
X. Bao, T. Muramatsu, and K. Sugahara (2005)
J. Biol. Chem. 280, 35318-35328
   Abstract »    Full Text »    PDF »
Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor.
A. W. McGee, Y. Yang, Q. S. Fischer, N. W. Daw, and S. M. Strittmatter (2005)
Science 309, 2222-2226
   Abstract »    Full Text »    PDF »
Versican in the Developing Brain: Lamina-Specific Expression in Interneuronal Subsets and Role in Presynaptic Maturation.
M. Yamagata and J. R. Sanes (2005)
J. Neurosci. 25, 8457-8467
   Abstract »    Full Text »    PDF »
A Functional Dermatan Sulfate Epitope Containing Iduronate(2-O-sulfate){alpha}1-3GalNAc(6-O-sulfate) Disaccharide in the Mouse Brain: DEMONSTRATION USING A NOVEL MONOCLONAL ANTIBODY RAISED AGAINST DERMATAN SULFATE OF ASCIDIAN ASCIDIA NIGRA.
X. Bao, M. S. G. Pavao, J. C. dos Santos, and K. Sugahara (2005)
J. Biol. Chem. 280, 23184-23193
   Abstract »    Full Text »    PDF »
Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains.
X. Bao, T. Mikami, S. Yamada, A. Faissner, T. Muramatsu, and K. Sugahara (2005)
J. Biol. Chem. 280, 9180-9191
   Abstract »    Full Text »    PDF »
Structural and Functional Characterization of Oversulfated Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from the Notochord of Hagfish: NEURITOGENIC AND BINDING ACTIVITIES FOR GROWTH FACTORS AND NEUROTROPHIC FACTORS.
C. D. Nandini, T. Mikami, M. Ohta, N. Itoh, F. Akiyama-Nambu, and K. Sugahara (2004)
J. Biol. Chem. 279, 50799-50809
   Abstract »    Full Text »    PDF »
A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB.
T. A. Pham, S. J. Graham, S. Suzuki, A. Barco, E. R. Kandel, B. Gordon, and M. E. Lickey (2004)
Learn. Mem. 11, 738-747
   Abstract »    Full Text »    PDF »
Sensitive Periods in the Development of the Brain and Behavior.
E. I. Knudsen (2004)
J. Cogn. Neurosci. 16, 1412-1425
   Abstract »    Full Text »    PDF »
Synaptic and Molecular Mechanisms Regulating Plasticity during Early Learning.
K. W. NORDEEN and E. J. NORDEEN (2004)
Ann. N.Y. Acad. Sci. 1016, 416-437
   Abstract »    Full Text »    PDF »
Absence of Glial Fibrillary Acidic Protein and Vimentin Prevents Hypertrophy of Astrocytic Processes and Improves Post-Traumatic Regeneration.
U. Wilhelmsson, L. Li, M. Pekna, C.-H. Berthold, S. Blom, C. Eliasson, O. Renner, E. Bushong, M. Ellisman, T. E. Morgan, et al. (2004)
J. Neurosci. 24, 5016-5021
   Abstract »    Full Text »    PDF »
Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth.
Y. Wu, W. Sheng, L. Chen, H. Dong, V. Lee, F. Lu, C. S. Wong, W.-Y. Lu, and B. B. Yang (2004)
Mol. Biol. Cell 15, 2093-2104
   Abstract »    Full Text »    PDF »
Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Embryonic Pig Brain, Which Contain a Higher Proportion of L-Iduronic Acid than Those from Adult Pig Brain, Exhibit Neuritogenic and Growth Factor Binding Activities.
X. Bao, S. Nishimura, T. Mikami, S. Yamada, N. Itoh, and K. Sugahara (2004)
J. Biol. Chem. 279, 9765-9776
   Abstract »    Full Text »    PDF »
A Novel DNA Enzyme Reduces Glycosaminoglycan Chains in the Glial Scar and Allows Microtransplanted Dorsal Root Ganglia Axons to Regenerate beyond Lesions in the Spinal Cord.
B. Grimpe and J. Silver (2004)
J. Neurosci. 24, 1393-1397
   Abstract »    Full Text »    PDF »
Proteoglycans and Brain Repair.
F. Properzi and J. W. Fawcett (2004)
Physiology 19, 33-38
   Abstract »    Full Text »    PDF »
Motility of dendritic spines in visual cortex in vivo: Changes during the critical period and effects of visual deprivation.
A. Majewska and M. Sur (2003)
PNAS 100, 16024-16029
   Abstract »    Full Text »    PDF »
Oversulfated Dermatan Sulfate Exhibits Neurite Outgrowth-promoting Activity toward Embryonic Mouse Hippocampal Neurons: IMPLICATIONS OF DERMATAN SULFATE IN NEURITOGENESIS IN THE BRAIN.
M. Hikino, T. Mikami, A. Faissner, A.-C. E. S. Vilela-Silva, M. S. G. Pavao, and K. Sugahara (2003)
J. Biol. Chem. 278, 43744-43754
   Abstract »    Full Text »    PDF »
Rapid Critical Period Induction by Tonic Inhibition in Visual Cortex.
Y. Iwai, M. Fagiolini, K. Obata, and T. K. Hensch (2003)
J. Neurosci. 23, 6695-6702
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)