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Science 25 October 2002:
Vol. 298. no. 5594, pp. 776 - 780
DOI: 10.1126/science.1075333
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Review

Postsynaptic Signaling and Plasticity Mechanisms

Morgan Sheng,* Myung Jong Kim

In excitatory synapses of the brain, specific receptors in the postsynaptic membrane lie ready to respond to the release of the neurotransmitter glutamate from the presynaptic terminal. Upon stimulation, these glutamate receptors activate multiple biochemical pathways that transduce signals into the postsynaptic neuron. Different kinds of synaptic activity elicit different patterns of postsynaptic signals that lead to short- or long-lasting strengthening or weakening of synaptic transmission. The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge.

Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
*   To whom correspondence should be addressed. E-mail: msheng{at}mit.edu

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E. Park, M. Na, J. Choi, S. Kim, J.-R. Lee, J. Yoon, D. Park, M. Sheng, and E. Kim (2003)
J. Biol. Chem. 278, 19220-19229
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Mutation and Activation of Galpha s Similarly Alters Pre- and Postsynaptic Mechanisms Modulating Neurotransmission.
R. B. Renden and K. Broadie (2003)
J Neurophysiol 89, 2620-2638
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Assembly of Cell Regulatory Systems Through Protein Interaction Domains.
T. Pawson and P. Nash (2003)
Science 300, 445-452
   Abstract »    Full Text »    PDF »
Synapse formation is regulated by the signaling adaptor GIT1.
H. Zhang, D. J. Webb, H. Asmussen, and A. F. Horwitz (2003)
J. Cell Biol. 161, 131-142
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)