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Originally published in Science Express on 12 September 2002
Science 18 October 2002:
Vol. 298. no. 5593, pp. 601 - 604
DOI: 10.1126/science.1073823
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Reports

A Stem Cell Molecular Signature

Natalia B. Ivanova, John T. Dimos, Christoph Schaniel, Jason A. Hackney, Kateri A. Moore, Ihor R. Lemischka*

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
*   To whom correspondence should be addressed: E-mail: ilemischka{at}molbio.princeton.edu

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Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
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Progressive and Controlled Development of Mouse Dendritic Cells from Flt3+CD11b+ Progenitors In Vitro.
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Blood 105, 1905-1915
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Concentrative Uptake of Cyclic ADP-ribose Generated by BST-1+ Stroma Stimulates Proliferation of Human Hematopoietic Progenitors.
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Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.
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