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Originally published in Science Express on 12 September 2002
Science 18 October 2002:
Vol. 298. no. 5593, pp. 601 - 604
DOI: 10.1126/science.1073823
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Reports

A Stem Cell Molecular Signature

Natalia B. Ivanova, John T. Dimos, Christoph Schaniel, Jason A. Hackney, Kateri A. Moore, Ihor R. Lemischka*

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
*   To whom correspondence should be addressed: E-mail: ilemischka{at}molbio.princeton.edu

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Stem Cells 24, 722-730
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Global Gene Expression Profile of Human Cord Blood-Derived CD133+ Cells.
T. Jaatinen, H. Hemmoranta, S. Hautaniemi, J. Niemi, D. Nicorici, J. Laine, O. Yli-Harja, and J. Partanen (2006)
Stem Cells 24, 631-641
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Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease.
M. L. Weiss, S. Medicetty, A. R. Bledsoe, R. S. Rachakatla, M. Choi, S. Merchav, Y. Luo, M. S. Rao, G. Velagaleti, and D. Troyer (2006)
Stem Cells 24, 781-792
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Differential mRNA Processing in Hematopoietic Stem Cells.
T. V. Bowman, A. J. McCooey, A. A. Merchant, C. A. Ramos, P. Fonseca, A. Poindexter, S. B. Bradfute, D. M. Oliveira, R. Green, Y. Zheng, et al. (2006)
Stem Cells 24, 662-670
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Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.
C. J. Luckey, D. Bhattacharya, A. W. Goldrath, I. L. Weissman, C. Benoist, and D. Mathis (2006)
PNAS 103, 3304-3309
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Inseparably Tied: Functional and Antioxidative Capacity of Endothelial Progenitor Cells.
J. Haendeler and S. Dimmeler (2006)
Circ. Res. 98, 157-158
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Impaired Angiogenesis in Glutathione Peroxidase-1-Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction.
G. Galasso, S. Schiekofer, K. Sato, R. Shibata, D. E. Handy, N. Ouchi, J. A. Leopold, J. Loscalzo, and K. Walsh (2006)
Circ. Res. 98, 254-261
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Transcriptional profiling of the developmentally important signalling pathways in human embryonic stem cells.
J.-Y. Rho, K. Yu, J.-S. Han, J.-I. Chae, D.-B. Koo, H.-S. Yoon, S.-Y. Moon, K.-K. Lee, and Y.-M. Han (2006)
Hum. Reprod. 21, 405-412
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ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.
T. Brambrink, K. Hochedlinger, G. Bell, and R. Jaenisch (2006)
PNAS 103, 933-938
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Eradication of Leukemia Stem Cells as a New Goal of Therapy in Leukemia.
F. Ravandi and Z. Estrov (2006)
Clin. Cancer Res. 12, 340-344
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Identification of Candidate Regulators of Embryonic Stem Cell Differentiation by Comparative Phosphoprotein Affinity Profiling.
L. G. Puente, D. J. Borris, J.-F. Carriere, J. F. Kelly, and L. A. Megeney (2006)
Mol. Cell. Proteomics 5, 57-67
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