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Natalia B. Ivanova,John T. Dimos,Christoph Schaniel,Jason A. Hackney,Kateri A. Moore,Ihor R. Lemischka*
Mechanisms regulating self-renewal and cell fate decisions in
mammalian stem cells are poorly understood. We determined globalgene
expression profiles for mouse and human hematopoietic stemcells and
other stages of the hematopoietic hierarchy. Murineand human
hematopoietic stem cells share a number of expressedgene products,
which define key conserved regulatory pathwaysin this developmental
system. Moreover, in the mouse, a portionof the genetic program of
hematopoietic stem cells is shared withembryonic and neural stem
cells. This overlapping set of geneproducts represents a molecular
signature of stem cells.
Department of Molecular Biology, Princeton University, Princeton,
NJ 08544, USA.
*
To whom correspondence should be addressed: E-mail:
ilemischka{at}molbio.princeton.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
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[DOI: 10.1126/science.1086384] |Full Text »|PDF »
TECHNICAL COMMENTS
Alexei V. Evsikov and Davor Solter (17 October 2003) Science302 (5644), 393c.
[DOI: 10.1126/science.1082380] |Full Text »|PDF »
TECHNICAL COMMENTS
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[DOI: 10.1126/science.1088249] |Full Text »|PDF »
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Differential mRNA Processing in Hematopoietic Stem Cells.
T. V. Bowman, A. J. McCooey, A. A. Merchant, C. A. Ramos, P. Fonseca, A. Poindexter, S. B. Bradfute, D. M. Oliveira, R. Green, Y. Zheng, et al. (2006)
Stem Cells
24, 662-670
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Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.
C. J. Luckey, D. Bhattacharya, A. W. Goldrath, I. L. Weissman, C. Benoist, and D. Mathis (2006)
PNAS
103, 3304-3309
|Abstract »|Full Text »|PDF »
Inseparably Tied: Functional and Antioxidative Capacity of Endothelial Progenitor Cells.
J. Haendeler and S. Dimmeler (2006)
Circ. Res.
98, 157-158
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Impaired Angiogenesis in Glutathione Peroxidase-1-Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction.
G. Galasso, S. Schiekofer, K. Sato, R. Shibata, D. E. Handy, N. Ouchi, J. A. Leopold, J. Loscalzo, and K. Walsh (2006)
Circ. Res.
98, 254-261
|Abstract »|Full Text »|PDF »
Transcriptional profiling of the developmentally important signalling pathways in human embryonic stem cells.
J.-Y. Rho, K. Yu, J.-S. Han, J.-I. Chae, D.-B. Koo, H.-S. Yoon, S.-Y. Moon, K.-K. Lee, and Y.-M. Han (2006)
Hum. Reprod.
21, 405-412
|Abstract »|Full Text »|PDF »
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.
T. Brambrink, K. Hochedlinger, G. Bell, and R. Jaenisch (2006)
PNAS
103, 933-938
|Abstract »|Full Text »|PDF »
Eradication of Leukemia Stem Cells as a New Goal of Therapy in Leukemia.