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Originally published in Science Express on 12 September 2002
Science 18 October 2002:
Vol. 298. no. 5593, pp. 597 - 600
DOI: 10.1126/science.1072530
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Reports

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

Miguel Ramalho-Santos,1 Soonsang Yoon,2 Yumi Matsuzaki,2 Richard C. Mulligan,2 Douglas A. Melton1*

The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes (represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.

1 Department of Molecular and Cellular Biology and Howard Hughes Medical Institute (HHMI), Harvard University, Cambridge, MA 02138, USA.
2 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail: dmelton{at}mcb.harvard.edu

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   Abstract »    Full Text »    PDF »
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.
R. D. Unwin, D. L. Smith, D. Blinco, C. L. Wilson, C. J. Miller, C. A. Evans, E. Jaworska, S. A. Baldwin, K. Barnes, A. Pierce, et al. (2006)
Blood 107, 4687-4694
   Abstract »    Full Text »    PDF »
Failure of Transdifferentiation of Adult Hematopoietic Stem Cells into Neurons.
L. Roybon, Z. Ma, F. Asztely, A. Fosum, S. E. W. Jacobsen, P. Brundin, and J.-Y. Li (2006)
Stem Cells 24, 1594-1604
   Abstract »    Full Text »    PDF »
Gene Expression Programs during Shoot, Root, and Callus Development in Arabidopsis Tissue Culture.
P. Che, S. Lall, D. Nettleton, and S. H. Howell (2006)
Plant Physiology 141, 620-637
   Abstract »    Full Text »    PDF »
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells.
M. Pritsker, N. R. Ford, H. T. Jenq, and I. R. Lemischka (2006)
PNAS 103, 6946-6951
   Abstract »    Full Text »    PDF »
Hematopoietic-Osteoblastic Interactions in the Hematopoietic Stem Cell Niche.
L. M. Calvi (2006)
IBMS BoneKEy 3, 10-18
   Abstract »    Full Text »    PDF »
Molecular Profile and Partial Functional Analysis of Novel Endothelial Cell-Derived Growth Factors that Regulate Hematopoiesis.
J. P. Chute, G. G. Muramoto, H. K. Dressman, G. Wolfe, N. J. Chao, and S. Lin (2006)
Stem Cells 24, 1315-1327
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The Unique 473HD-Chondroitinsulfate Epitope Is Expressed by Radial Glia and Involved in Neural Precursor Cell Proliferation.
A. von Holst, S. Sirko, and A. Faissner (2006)
J. Neurosci. 26, 4082-4094
   Abstract »    Full Text »    PDF »
The Production and Directed Differentiation of Human Embryonic Stem Cells.
A. Trounson (2006)
Endocr. Rev. 27, 208-219
   Abstract »    Full Text »    PDF »
Human Side Population Keratinocytes Exhibit Long-Term Proliferative Potential and a Specific Gene Expression Profile and Can Form a Pluristratified Epidermis.
G. Larderet, N. O. Fortunel, P. Vaigot, M. Cegalerba, P. Maltere, O. Zobiri, X. Gidrol, G. Waksman, and M. T. Martin (2006)
Stem Cells 24, 965-974
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Embryonic Stem-Derived Versus Somatic Neural Stem Cells: A Comparative Analysis of Their Developmental Potential and Molecular Phenotype.
E. Colombo, S. G. Giannelli, R. Galli, E. Tagliafico, C. Foroni, E. Tenedini, S. Ferrari, S. Ferrari, G. Corte, A. Vescovi, et al. (2006)
Stem Cells 24, 825-834
   Abstract »    Full Text »    PDF »
Defining a Developmental Path to Neural Fate by Global Expression Profiling of Mouse Embryonic Stem Cells and Adult Neural Stem/Progenitor Cells.
K. Aiba, A. A. Sharov, M. G. Carter, C. Foroni, A. L. Vescovi, and M. S.H. Ko (2006)
Stem Cells 24, 889-895
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The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets.
H. B. Sieburg, R. H. Cho, B. Dykstra, N. Uchida, C. J. Eaves, and C. E. Muller-Sieburg (2006)
Blood 107, 2311-2316
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Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow.
A. B. Balazs, A. J. Fabian, C. T. Esmon, and R. C. Mulligan (2006)
Blood 107, 2317-2321
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Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma.
J. D. Raman, N. P. Mongan, L. Liu, S. K. Tickoo, D. M. Nanus, D. S. Scherr, and L. J. Gudas (2006)
Carcinogenesis 27, 499-507
   Abstract »    Full Text »    PDF »


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