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Originally published in Science Express on 26 September 2002
Science 18 October 2002:
Vol. 298. no. 5593, pp. 580 - 584
DOI: 10.1126/science.1076996
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Reports

Microfluidic Large-Scale Integration

Todd Thorsen,1 Sebastian J. Maerkl,1 Stephen R. Quake2*

We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.

1 Biochemistry and Molecular Biophysics Option,
2 Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA.
*   To whom correspondence should be addressed. E-mail: quake{at}caltech.edu

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