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Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population
Oumou Niaré,12*Kyriacos Markianos,3*Jennifer Volz,5*Frederick Oduol,1Abdoulaye Touré,2Magaran Bagayoko,2Djibril Sangaré,2Sekou F. Traoré,2Rui Wang,5Claudia Blass,5Guimogo Dolo,2Madama Bouaré,2Fotis C. Kafatos,5Leonid Kruglyak,34Yeya T. Touré,2Kenneth D. Vernick1
Successful propagation of the malaria parasite
Plasmodium falciparum within a susceptible mosquito vector
is a prerequisitefor the transmission of malaria. A field-based
genetic analysisof the major human malaria vector, Anopheles
gambiae, has revealednatural factors that reduce the transmission
of P. falciparum.Differences in P. falciparum
oocyst numbers between mosquito isofemalefamilies fed on the same
infected blood indicated a large geneticcomponent affecting resistance
to the parasite, and genome-widescanning in pedigrees of wild
mosquitoes detected segregatingresistance alleles. The apparently high
natural frequency of resistancealleles suggests that malaria parasites
(or a similar pathogen)exert a significant selective pressure on
vector populations.
1 Department of Medical and Molecular
Parasitology, New York University School of Medicine, 341 East 25th
Street, New York, NY 10010, USA.
2 Département
d'Epidémiologie des Affectations Parasitaires, Faculté de
Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale
1805, Bamako, Mali.
3 Fred Hutchinson Cancer
Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
4 Howard Hughes Medical Institute, 4000 Jones Bridge
Road, Chevy Chase, MD 20815, USA.
5 European
Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg,
Germany.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
kenneth.vernick{at}nyu.edu
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