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Catherine A. Hill,1*A. Nicole Fox,2*R. Jason Pitts,2*Lauren B. Kent,3Perciliz L. Tan,1Mathew A. Chrystal,1Anibal Cravchik,4Frank H. Collins,1Hugh M. Robertson,3Laurence J. Zwiebel2
We used bioinformatic approaches to identify a total of 276 G
protein-coupled receptors (GPCRs) from the Anopheles
gambiaegenome. These include GPCRs that are likely to play roles
in pathwaysaffecting almost every aspect of the mosquito's life
cycle. Seventy-ninecandidate odorant receptors were characterized for
tissue expressionand, along with 76 putative gustatory receptors, for
their molecularevolution relative to Drosophila
melanogaster. Examples of lineage-specificgene expansions were
observed as well as a single instance ofunusually high sequence
conservation.
1 Department of Biological Sciences, University
of Notre Dame, Notre Dame, IN 46556, USA.
2 Department of Biological Sciences, Program in
Developmental Biology and Center for Molecular Neuroscience, Vanderbilt
University, Nashville, TN 37235, USA.
3 Department
of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL
61801, USA.
4 Celera Diagnostics, 45 West Gude
Drive, Rockville, MD 20850-1232, USA.
*
These authors contributed equally to this work.
To whom all correspondence should be addressed.
E-mail: l.zwiebel{at}vanderbilt.edu
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