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Neuropeptides and Peptide Hormones in Anopheles gambiae
Michael A. Riehle,1*Stephen F. Garczynski,2*Joe W. Crim,2Catherine A. Hill,3Mark R. Brown1
The African malaria mosquito, Anopheles gambiae,
is specialized for rapid completion of development and reproduction. A
vertebrateblood meal is required for egg production, and multiple
feedingssubsequently allow transmission of malaria parasites,
Plasmodiumspp. Regulatory peptides from 35 genes
annotated from the A. gambiaegenome likely coordinate these
and other physiological processes.Plasmodium parasites may
affect actions of newly identified insulin-likepeptides, which
coordinate growth and reproduction of its vector,A. gambiae, as in Drosophila melanogaster,
Caenorhabditis elegans,and mammals. This genomic
information provides a basis to expandunderstanding of hematophagy and
pathogen transmission in thismosquito.
1 Department of Entomology,
2 Department of Cellular Biology, University of
Georgia, Athens, GA 30602, USA.
3 Department of
Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
mbrown{at}bugs.ent.uga.edu
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