Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
The Plasmodium falciparum Genome-- a Blueprint for Erythrocyte Invasion
Alan F. Cowman,Brendan S. Crabb
Erythrocyte invasion by Plasmodium
falciparum involves multiple ligand-receptor interactions and
numerous apparent redundancies.The genome sequence of this parasite
reveals new gene familiesencoding proteins that appear to mediate
erythrocyte invasion.
Walter and Eliza Hall Institute of Medical Research, PO Royal
Melbourne Hospital, Melbourne, Victoria 3050, Australia. E-mail:
cowman{at}wehi.edu.au
The editors suggest the following Related Resources on Science sites:
In Science Magazine
VIEWPOINT
A. della Torre, C. Costantini, N. J. Besansky, A. Caccone, V. Petrarca, J. R. Powell, and M. Coluzzi (4 October 2002) Science298 (5591), 115.
[DOI: 10.1126/science.1078170] |Abstract »|Full Text »|PDF »
VIEWPOINT
Thomas W. Scott, Willem Takken, Bart G. J. Knols, and Christophe Boëte (4 October 2002) Science298 (5591), 117.
[DOI: 10.1126/science.298.5591.117] |Abstract »|Full Text »|PDF »
VIEWPOINT
Luke Alphey, C. Ben Beard, Peter Billingsley, Maureen Coetzee, Andrea Crisanti, Chris Curtis, Paul Eggleston, Charles Godfray, Janet Hemingway, Marcelo Jacobs-Lorena, Anthony A. James, Fotis C. Kafatos, Louis G. Mukwaya, Michael Paton, Jeffrey R. Powell, William Schneider, Thomas W. Scott, Barbara Sina, Robert Sinden, Steven Sinkins, Andrew Spielman, Yeya Touré, and Frank H. Collins (4 October 2002) Science298 (5591), 119.
[DOI: 10.1126/science.1078278] |Abstract »|Full Text »|PDF »
VIEWPOINT
Louis H. Miller and Brian Greenwood (4 October 2002) Science298 (5591), 121.
[DOI: 10.1126/science.1078048] |Abstract »|Full Text »|PDF »
VIEWPOINT
Jeffrey D. Sachs (4 October 2002) Science298 (5591), 122.
[DOI: 10.1126/science.1077900] |Abstract »|Full Text »|PDF »
VIEWPOINT
Thomas E. Wellems (4 October 2002) Science298 (5591), 124.
[DOI: 10.1126/science.1078167] |Abstract »|Full Text »|PDF »
RESEARCH ARTICLES
Robert A. Holt, G. Mani Subramanian, Aaron Halpern, Granger G. Sutton, Rosane Charlab, Deborah R. Nusskern, Patrick Wincker, Andrew G. Clark, José M. C. Ribeiro, Ron Wides, Steven L. Salzberg, Brendan Loftus, Mark Yandell, William H. Majoros, Douglas B. Rusch, Zhongwu Lai, Cheryl L. Kraft, Josep F. Abril, Veronique Anthouard, Peter Arensburger, Peter W. Atkinson, Holly Baden, Veronique de Berardinis, Danita Baldwin, Vladimir Benes, Jim Biedler, Claudia Blass, Randall Bolanos, Didier Boscus, Mary Barnstead, Shuang Cai, Angela Center, Kabir Chatuverdi, George K. Christophides, Mathew A. Chrystal, Michele Clamp, Anibal Cravchik, Val Curwen, Ali Dana, Art Delcher, Ian Dew, Cheryl A. Evans, Michael Flanigan, Anne Grundschober-Freimoser, Lisa Friedli, Zhiping Gu, Ping Guan, Roderic Guigo, Maureen E. Hillenmeyer, Susanne L. Hladun, James R. Hogan, Young S. Hong, Jeffrey Hoover, Olivier Jaillon, Zhaoxi Ke, Chinnappa Kodira, Elena Kokoza, Anastasios Koutsos, Ivica Letunic, Alex Levitsky, Yong Liang, Jhy-Jhu Lin, Neil F. Lobo, John R. Lopez, Joel A. Malek, Tina C. McIntosh, Stephan Meister, Jason Miller, Clark Mobarry, Emmanuel Mongin, Sean D. Murphy, David A. O'Brochta, Cynthia Pfannkoch, Rong Qi, Megan A. Regier, Karin Remington, Hongguang Shao, Maria V. Sharakhova, Cynthia D. Sitter, Jyoti Shetty, Thomas J. Smith, Renee Strong, Jingtao Sun, Dana Thomasova, Lucas Q. Ton, Pantelis Topalis, Zhijian Tu, Maria F. Unger, Brian Walenz, Aihui Wang, Jian Wang, Mei Wang, Xuelan Wang, Kerry J. Woodford, Jennifer R. Wortman, Martin Wu, Alison Yao, Evgeny M. Zdobnov, Hongyu Zhang, Qi Zhao, Shaying Zhao, Shiaoping C. Zhu, Igor Zhimulev, Mario Coluzzi, Alessandra della Torre, Charles W. Roth, Christos Louis, Francis Kalush, Richard J. Mural, Eugene W. Myers, Mark D. Adams, Hamilton O. Smith, Samuel Broder, Malcolm J. Gardner, Claire M. Fraser, Ewan Birney, Peer Bork, Paul T. Brey, J. Craig Venter, Jean Weissenbach, Fotis C. Kafatos, Frank H. Collins, and Stephen L. Hoffman (4 October 2002) Science298 (5591), 129.
[DOI: 10.1126/science.1076181] |Abstract »|Full Text »|PDF »|Supporting Online Material »|Figure 1 »
EDITORIAL
Kathryn S. Aultman, Michael Gottlieb, Maria Y. Giovanni, and Anthony S. Fauci (4 October 2002) Science298 (5591), 13.
[DOI: 10.1126/science.298.5591.13] |Summary »|PDF »
RESEARCH ARTICLES
Evgeny M. Zdobnov, Christian von Mering, Ivica Letunic, David Torrents, Mikita Suyama, Richard R. Copley, George K. Christophides, Dana Thomasova, Robert A. Holt, G. Mani Subramanian, Hans-Michael Mueller, George Dimopoulos, John H. Law, Michael A. Wells, Ewan Birney, Rosane Charlab, Aaron L. Halpern, Elena Kokoza, Cheryl L. Kraft, Zhongwu Lai, Suzanna Lewis, Christos Louis, Carolina Barillas-Mury, Deborah Nusskern, Gerald M. Rubin, Steven L. Salzberg, Granger G. Sutton, Pantelis Topalis, Ron Wides, Patrick Wincker, Mark Yandell, Frank H. Collins, Jose Ribeiro, William M. Gelbart, Fotis C. Kafatos, and Peer Bork (4 October 2002) Science298 (5591), 149.
[DOI: 10.1126/science.1077061] |Abstract »|Full Text »|PDF »|Supporting Online Material »
RESEARCH ARTICLES
George K. Christophides, Evgeny Zdobnov, Carolina Barillas-Mury, Ewan Birney, Stephanie Blandin, Claudia Blass, Paul T. Brey, Frank H. Collins, Alberto Danielli, George Dimopoulos, Charles Hetru, Ngo T. Hoa, Jules A. Hoffmann, Stefan M. Kanzok, Ivica Letunic, Elena A. Levashina, Thanasis G. Loukeris, Gareth Lycett, Stephan Meister, Kristin Michel, Luis F. Moita, Hans-Michael Müller, Mike A. Osta, Susan M. Paskewitz, Jean-Marc Reichhart, Andrey Rzhetsky, Laurent Troxler, Kenneth D. Vernick, Dina Vlachou, Jennifer Volz, Christian von Mering, Jiannong Xu, Liangbiao Zheng, Peer Bork, and Fotis C. Kafatos (4 October 2002) Science298 (5591), 159.
[DOI: 10.1126/science.1077136] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Michael A. Riehle, Stephen F. Garczynski, Joe W. Crim, Catherine A. Hill, and Mark R. Brown (4 October 2002) Science298 (5591), 172.
[DOI: 10.1126/science.1076827] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Hilary Ranson, Charles Claudianos, Federica Ortelli, Christelle Abgrall, Janet Hemingway, Maria V. Sharakhova, Maria F. Unger, Frank H. Collins, and René Feyereisen (4 October 2002) Science298 (5591), 179.
[DOI: 10.1126/science.1076781] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Igor V. Sharakhov, Andrew C. Serazin, Olga G. Grushko, Ali Dana, Neil Lobo, Maureen E. Hillenmeyer, Richard Westerman, Jeanne Romero-Severson, Carlo Costantini, N'Fale Sagnon, Frank H. Collins, and Nora J. Besansky (4 October 2002) Science298 (5591), 182.
[DOI: 10.1126/science.1076803] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Oumou Niaré, Kyriacos Markianos, Jennifer Volz, Frederick Oduol, Abdoulaye Touré, Magaran Bagayoko, Djibril Sangaré, Sekou F. Traoré, Rui Wang, Claudia Blass, Guimogo Dolo, Madama Bouaré, Fotis C. Kafatos, Leonid Kruglyak, Yeya T. Touré, and Kenneth D. Vernick (4 October 2002) Science298 (5591), 213.
[DOI: 10.1126/science.1073420] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Sarah K. Volkman, Daniel L. Hartl, Dyann F. Wirth, Kaare M. Nielsen, Mehee Choi, Serge Batalov, Yingyao Zhou, David Plouffe, Karine G. Le Roch, Ruben Abagyan, and Elizabeth A. Winzeler (4 October 2002) Science298 (5591), 216.
[DOI: 10.1126/science.1075642] |Abstract »|Full Text »|PDF »|Supporting Online Material »
NEWS OF THE WEEK
Elizabeth Pennisi (4 October 2002) Science298 (5591), 33a.
[DOI: 10.1126/science.298.5591.33a] |Summary »|Full Text »|PDF »
PERSPECTIVES
I. M. Hastings, P. G. Bray, and S. A. Ward (4 October 2002) Science298 (5591), 74.
[DOI: 10.1126/science.1077573] |Summary »|Full Text »|PDF »
INTRODUCTION TO SPECIAL ISSUE
Barbara R. Jasny, Smith Orla M., Leslie Roberts, and Martin Enserink (4 October 2002) Science298 (5591), 77.
[DOI: 10.1126/science.298.5591.77] |Summary »|PDF »
VIEWPOINT
Carlos M. Morel, Yeya T. Touré, Boris Dobrokhotov, and Ayoade M. J. Oduola (4 October 2002) Science298 (5591), 79.
[DOI: 10.1126/science.1078047] |Abstract »|Full Text »|PDF »
NEWS
Stephen Budiansky (4 October 2002) Science298 (5591), 80.
[DOI: 10.1126/science.298.5591.80] |Summary »|Full Text »|PDF »
NEWS
Leslie Roberts (4 October 2002) Science298 (5591), 82.
[DOI: 10.1126/science.298.5591.82] |Summary »|PDF »
NEWS
Gretchen Vogel (4 October 2002) Science298 (5591), 87.
[DOI: 10.1126/science.298.5591.87] |Summary »|Full Text »|PDF »
NEWS
Martin Enserink (4 October 2002) Science298 (5591), 90.
[DOI: 10.1126/science.298.5591.90] |Summary »|Full Text »|PDF »
NEWS
Martin Enserink (4 October 2002) Science298 (5591), 92.
[DOI: 10.1126/science.298.5591.92] |Summary »|Full Text »|PDF »
NEWS
Gretchen Vogel (4 October 2002) Science298 (5591), 94.
[DOI: 10.1126/science.298.5591.94] |Summary »|Full Text »|PDF »
VIEWPOINT
Janet Hemingway, Linda Field, and John Vontas (4 October 2002) Science298 (5591), 96.
[DOI: 10.1126/science.1078052] |Abstract »|Full Text »|PDF »
VIEWPOINT
Thomas C. Kaufman, David W. Severson, and Gene E. Robinson (4 October 2002) Science298 (5591), 97.
[DOI: 10.1126/science.1077901] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion.
P. R. Sanders, L. M. Kats, D. R. Drew, R. A. O'Donnell, M. O'Neill, A. G. Maier, R. L. Coppel, and B. S. Crabb (2006)
Infect. Immun.
74, 4330-4338
|Abstract »|Full Text »|PDF »
Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum.
P. R. Sanders, P. R. Gilson, G. T. Cantin, D. C. Greenbaum, T. Nebl, D. J. Carucci, M. J. McConville, L. Schofield, A. N. Hodder, J. R. Yates III, et al. (2005)
J. Biol. Chem.
280, 40169-40176
|Abstract »|Full Text »|PDF »
Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo.
R. Tewari, S. A. Ogun, R. S. Gunaratne, A. Crisanti, and A. A. Holder (2005)
Blood
105, 394-396
|Abstract »|Full Text »|PDF »
A Novel Erythrocyte Binding Antigen-175 Paralogue from Plasmodium falciparum Defines a New Trypsin-resistant Receptor on Human Erythrocytes.
T.-W. Gilberger, J. K. Thompson, T. Triglia, R. T. Good, M. T. Duraisingh, and A. F. Cowman (2003)
J. Biol. Chem.
278, 14480-14486
|Abstract »|Full Text »|PDF »
