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Science 4 October 2002:
Vol. 298. no. 5591, pp. 124 - 126
DOI: 10.1126/science.1078167
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Plasmodium Chloroquine Resistance and the Search for a Replacement Antimalarial Drug

Thomas E. Wellems

Genetic and biochemical research is providing new information on the mechanism of chloroquine resistance. Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. E-mail: tew{at}helix.nih.gov

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in the Plasmodial Surface Anion Channel Reduce Leupeptin Uptake and Can Confer Drug Resistance in Plasmodium falciparum-Infected Erythrocytes.
G. Lisk, M. Pain, I. Y. Gluzman, S. Kambhampati, T. Furuya, X.-z. Su, M. P. Fay, D. E. Goldberg, and S. A. Desai (2008)
Antimicrob. Agents Chemother. 52, 2346-2354
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Real-Time PCR Assay for Rapid Detection and Analysis of PfCRT Haplotypes of Chloroquine-Resistant Plasmodium falciparum Isolates from India.
J. Keen, G. A. Farcas, K. Zhong, S. Yohanna, M. W. Dunne, and K. C. Kain (2007)
J. Clin. Microbiol. 45, 2889-2893
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Mosquito Phenoloxidase and Defensin Colocalize in Melanization Innate Immune Responses.
J. F. Hillyer and B. M. Christensen (2005)
J. Histochem. Cytochem. 53, 689-698
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Structural Basis of Fosmidomycin Action Revealed by the Complex with 2-C-Methyl-D-erythritol 4-phosphate Synthase (IspC). IMPLICATIONS FOR THE CATALYTIC MECHANISM AND ANTI-MALARIA DRUG DEVELOPMENT.
S. Steinbacher, J. Kaiser, W. Eisenreich, R. Huber, A. Bacher, and F. Rohdich (2003)
J. Biol. Chem. 278, 18401-18407
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