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Science 27 September 2002:
Vol. 297. no. 5590, pp. 2270 - 2275
DOI: 10.1126/science.1072152
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Reports

Gene Expression During the Life Cycle of Drosophila melanogaster

Michelle N. Arbeitman,1* Eileen E. M. Furlong,235 Farhad Imam,34* Eric Johnson,346* Brian H. Null,27* Bruce S. Baker,1 Mark A. Krasnow,34 Matthew P. Scott,24 Ronald W. Davis,37 Kevin P. White78dagger

Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.

1 Department of Biological Sciences,
2 Department of Developmental Biology and Department of Genetics,
3 Department of Biochemistry,
4 Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
5 Developmental Biology Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
6 Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
7 Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94306, USA.
8 Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
*   Co-first authors

dagger    To whom correspondence should be addressed. E-mail: kevin.white{at}yale.edu

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DNA Arrays: Applications and Implications for Circadian Biology.
T. K. Sato, S. Panda, S. A. Kay, and J. B. Hogenesch (2003)
J Biol Rhythms 18, 96-105
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Science. ISSN 0036-8075 (print), 1095-9203 (online)