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Science 20 September 2002:
Vol. 297. no. 5589, pp. 2060 - 2063
DOI: 10.1126/science.1072615
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Reports

A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory

Christine Bourgeois, Benedita Rocha, Corinne Tanchot*

The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation.

INSERM U345, Institut Necker, 156 Rue de Vaugirard, F-75730 Paris Cedex 15, France.
*   To whom correspondence should be addressed. E-mail: tanchot{at}necker.fr

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Differential Immunogenicity of Various Heterologous Prime-Boost Vaccine Regimens Using DNA and Viral Vectors in Healthy Volunteers.
J. M. Vuola, S. Keating, D. P. Webster, T. Berthoud, S. Dunachie, S. C. Gilbert, and A. V. S. Hill (2005)
J. Immunol. 174, 449-455
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Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival.
A. B. Adams, N. Shirasugi, T. R. Jones, M. M. Durham, E. A. Strobert, S. Cowan, P. Rees, R. Hendrix, K. Price, N. S. Kenyon, et al. (2005)
J. Immunol. 174, 542-550
   Abstract »    Full Text »    PDF »
Comparison of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses in HIV-1- and HIV-2-Infected Individuals in Senegal.
N. N. Zheng, N. B. Kiviat, P. S. Sow, S. E. Hawes, A. Wilson, H. Diallo-Agne, C. W. Critchlow, G. S. Gottlieb, L. Musey, and M. J. McElrath (2004)
J. Virol. 78, 13934-13942
   Abstract »    Full Text »    PDF »
Cutting Edge: A Critical Role for CD70 in CD8 T Cell Priming by CD40-Licensed APCs.
V. Y. Taraban, T. F. Rowley, and A. Al-Shamkhani (2004)
J. Immunol. 173, 6542-6546
   Abstract »    Full Text »    PDF »
Activation of Dendritic Cells That Cross-Present Tumor-Derived Antigen Licenses CD8+ CTL to Cause Tumor Eradication.
G. J. D. van Mierlo, Z. F. H. M. Boonman, H. M. H. Dumortier, A. Th. den Boer, M. F. Fransen, J. Nouta, E. I. H. van der Voort, R. Offringa, R. E. M. Toes, and C. J. M. Melief (2004)
J. Immunol. 173, 6753-6759
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Cutting Edge: Tumor-Specific CTL Are Constitutively Cross-Armed in Draining Lymph Nodes and Transiently Disseminate to Mediate Tumor Regression following Systemic CD40 Activation.
P. A. Stumbles, R. Himbeck, J. A. Frelinger, E. J. Collins, R. A. Lake, and B. W. S. Robinson (2004)
J. Immunol. 173, 5923-5928
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Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules.
N. Anfossi, S. H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C. B. DiCioccio, E. Tomasello, et al. (2004)
J. Immunol. 173, 3773-3782
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The Development of Functional CD8 T Cell Memory after Listeria monocytogenes Infection Is Not Dependent on CD40.
M. J. Montfort, H. G. A. Bouwer, C. R. Wagner, and D. J. Hinrichs (2004)
J. Immunol. 173, 4084-4090
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4-1BB and OX40 Dual Costimulation Synergistically Stimulate Primary Specific CD8 T Cells for Robust Effector Function.
S.-J. Lee, L. Myers, G. Muralimohan, J. Dai, Y. Qiao, Z. Li, R. S. Mittler, and A. T. Vella (2004)
J. Immunol. 173, 3002-3012
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An Evaluation of Enforced Rapid Proteasomal Degradation as a Means of Enhancing Vaccine-Induced CTL Responses.
S. B. J. Wong, C. B. Buck, X. Shen, and R. F. Siliciano (2004)
J. Immunol. 173, 3073-3083
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CD40 Engagement Enhances Antigen-Presenting Langerhans Cell Priming of IFN-{gamma}-Producing CD4+ and CD8+ T Cells Independently of IL-12.
A. V. Gorbachev and R. L. Fairchild (2004)
J. Immunol. 173, 2443-2452
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Functional Characterization of MHC Class II-Restricted CD8+CD4- and CD8-CD4- T Cell Responses to Infection in CD4-/- Mice.
E. L. Pearce, D. J. Shedlock, and H. Shen (2004)
J. Immunol. 173, 2494-2499
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Partial Activation of Neonatal CD11c+ Dendritic Cells and Induction of Adult-Like CD8+ Cytotoxic T Cell Responses by Synthetic Microspheres.
M. Regner, X. Martinez, E. Belnoue, C.-M. Sun, F. Boisgerault, P.-H. Lambert, C. Leclerc, and C.-A. Siegrist (2004)
J. Immunol. 173, 2669-2674
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