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Science 6 September 2002:
Vol. 297. no. 5587, pp. 1689 - 1692
DOI: 10.1126/science.1073176
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Reports

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

David M. Lee,13 Daniel S. Friend,2 Michael F. Gurish,13 Christophe Benoist,14 Diane Mathis,14 Michael B. Brenner13*

Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.

1 Department of Medicine and
2 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
3 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital; Harvard Medical School, Boston, MA 02115, USA.
4 Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
*   To whom correspondence should be addressed. E-mail: mbrenner{at}rics.bwh.harvard.edu

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   Abstract »    Full Text »    PDF »
Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease Course.
M. B. Tanzola, M. Robbie-Ryan, C. A. Gutekunst, and M. A. Brown (2003)
J. Immunol. 171, 4385-4391
   Abstract »    Full Text »    PDF »
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200.
G. J. Wright, H. Cherwinski, M. Foster-Cuevas, G. Brooke, M. J. Puklavec, M. Bigler, Y. Song, M. Jenmalm, D. Gorman, T. McClanahan, et al. (2003)
J. Immunol. 171, 3034-3046
   Abstract »    Full Text »    PDF »
Stat5 expression is critical for mast cell development and survival.
C. P. Shelburne, M. E. McCoy, R. Piekorz, V. Sexl, K.-H. Roh, S. M. Jacobs-Helber, S. R. Gillespie, D. P. Bailey, P. Mirmonsef, M. N. Mann, et al. (2003)
Blood 102, 1290-1297
   Abstract »    Full Text »    PDF »
The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover.
E. Tchougounova, G. Pejler, and M. Abrink (2003)
J. Exp. Med. 198, 423-431
   Abstract »    Full Text »    PDF »
Human Mast Cell {beta}-Tryptase Is a Gelatinase.
I. Fajardo and G. Pejler (2003)
J. Immunol. 171, 1493-1499
   Abstract »    Full Text »    PDF »
IL-18 Enhances Collagen-Induced Arthritis by Recruiting Neutrophils Via TNF-{alpha} and Leukotriene B4.
C. A. Cannetti, B. P. Leung, S. Culshaw, I. B. McInnes, F. Q. Cunha, and F. Y. Liew (2003)
J. Immunol. 171, 1009-1015
   Abstract »    Full Text »    PDF »
A Role for the Lymphotoxin/LIGHT Axis in the Pathogenesis of Murine Collagen-Induced Arthritis.
R. A. Fava, E. Notidis, J. Hunt, V. Szanya, N. Ratcliffe, A. Ngam-ek, A. R. de Fougerolles, A. Sprague, and J. L. Browning (2003)
J. Immunol. 171, 115-126
   Abstract »    Full Text »    PDF »
The Mast Cell in Inflammatory Arthritis.
D. E. Woolley (2003)
N. Engl. J. Med. 348, 1709-1711
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Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling.
J.-Y. Choe, B. Crain, S. R. Wu, and M. Corr (2003)
J. Exp. Med. 197, 537-542
   Abstract »    Full Text »    PDF »
The Burden of Pain on the Shoulders of Aging.
M. Beckman (2002)
Sci. Aging Knowl. Environ. 2002, oa1-1
   Abstract »    Full Text »    PDF »
Mast Cells Play a Key Role in Inflammatory Arthritis.
(2002)
Journal Watch Dermatology 2002, 13
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Mast Cells Play a Key Role in Inflammatory Arthritis.
(2002)
Journal Watch (General) 2002, 6
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