Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides
Sijbren Otto,*
Ricardo L. E. Furlan,
Jeremy K. M. Sanders
We have discovered two receptors for two different
guests from a single dynamic combinatorial library. Each of the two
guests amplifies the formation of a tightly binding host at the expense of unfit library members. Small differences in host-guest binding translate into useful differences in amplification. The selected hosts
could be readily synthesized using biased dynamic libraries that
contain only the right ratio of those building blocks that were
selected by the guests. These results establish dynamic combinatorial chemistry as a practical method not only for the discovery but also for
the synthesis of new receptors.
Department of Chemistry, University of Cambridge, Lensfield Road,
Cambridge CB2 1EW, UK.
*
To whom correspondence should be addressed. E-mail:
so230{at}cam.ac.uk
Present address: Universidad Nacional de Rosario,
Facultad de Ciencias Bioquímicas y Farmacéuticas,
Suipacha 531, 2000 Rosario, Argentina.
