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Science 26 July 2002:
Vol. 297. no. 5581, pp. 573 - 578
DOI: 10.1126/science.1069076
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Research Articles

Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

Jafar Mahdavi,1* Berit Sondén,1*dagger Marina Hurtig,1* Farzad O. Olfat,12 Lina Forsberg,1 Niamh Roche,3 Jonas Ångström,3 Thomas Larsson,3 Susann Teneberg,3 Karl-Anders Karlsson,3 Siiri Altraja,4 Torkel Wadström,5 Dangeruta Kersulyte,6 Douglas E. Berg,6 Andre Dubois,7 Christoffer Petersson,8 Karl-Eric Magnusson,8 Thomas Norberg,9 Frank Lindh,10 Bertil B. Lundskog,11 Anna Arnqvist,112 Lennart Hammarström,13 Thomas Borén1ddagger

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

1 Department of Odontology/Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
2 The Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden.
3 Institute of Medical Biochemistry, Göteborg University, Box 440, SE-405 30 Göteborg, Sweden.
4 Institute of Molecular and Cell Biology, Tartu University, EE-51010 Tartu, Estonia.
5 Department of Infectious Diseases and Medical Microbiology, Lund University, SE-223 62 Lund, Sweden.
6 Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.
7 Laboratory of Gastrointestinal and Liver Studies, Department of Medicine, USUHS, Bethesda, MD 20814-4799, USA.
8 Department of Molecular and Clinical Medicine, Division of Medical Microbiology, Linköping University, SE-581 85 Linköping, Sweden.
9 Department of Chemistry, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
10 IsoSep AB, Dalkärrsv. 11, SE-146 36 Tullinge, Sweden.
11 Department of Medical Biosciences/Clinical Cytology, Umeå University, SE-901 87 Umeå, Sweden.
12 Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.
13 Center for Biotechnology, Karolinska Institute, Novum, SE-141 57 Huddinge, Sweden.
*   These authors contributed equally to this work.

dagger    Present address: Unité de Génétique Mycobactérienne, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.

ddagger    To whom correspondence should be addressed. E-mail: Thomas.Boren{at}odont.umu.se

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