Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 26 July 2002:
Vol. 297. no. 5581, pp. 557 - 558
DOI: 10.1126/science.1075456

Viewpoint

Checking That Replication Breakdown Is Not Terminal

Antony M. Carr

Two new studies help to clarify the relationship between checkpoint proteins, recombination, and replication fork integrity.

Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. E-mail: a.m.carr{at}sussex.ac.uk


Read the Full Text



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Replication Stress Leads to Genome Instabilities in Arabidopsis DNA Polymerase {delta} Mutants.
D. Schuermann, O. Fritsch, J. M. Lucht, and B. Hohn (2009)
PLANT CELL 21, 2700-2714
   Abstract »    Full Text »    PDF »
Transcription of a Donor Enhances Its Use during Double-Strand Break-Induced Gene Conversion in Human Cells.
E. Schildkraut, C. A. Miller, and J. A. Nickoloff (2006)
Mol. Cell. Biol. 26, 3098-3105
   Abstract »    Full Text »    PDF »
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.
M. Kai, M. N. Boddy, P. Russell, and T. S.-F. Wang (2005)
Genes & Dev. 19, 919-932
   Abstract »    Full Text »    PDF »
SMC1 involvement in fragile site expression.
A. Musio, C. Montagna, T. Mariani, M. Tilenni, M. L. Focarelli, L. Brait, E. Indino, P. A. Benedetti, L. Chessa, A. Albertini, et al. (2005)
Hum. Mol. Genet. 14, 525-533
   Abstract »    Full Text »    PDF »
From The Cover: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
D. Cortez, G. Glick, and S. J. Elledge (2004)
PNAS 101, 10078-10083
   Abstract »    Full Text »    PDF »
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.
K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
Mol. Cell. Biol. 24, 5050-5059
   Abstract »    Full Text »    PDF »
Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses.
R. W. Sobol, M. Kartalou, K. H. Almeida, D. F. Joyce, B. P. Engelward, J. K. Horton, R. Prasad, L. D. Samson, and S. H. Wilson (2003)
J. Biol. Chem. 278, 39951-39959
   Abstract »    Full Text »    PDF »
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
E. J. Brown and D. Baltimore (2003)
Genes & Dev. 17, 615-628
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)