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Science 26 July 2002:
Vol. 297. no. 5581, pp. 547 - 551
DOI: 10.1126/science.1074740
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Review

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

John Rouse, Stephen P. Jackson

Left unrepaired, the myriad types of damage that can occur in genomic DNA pose a serious threat to the faithful transmission of the correct complement of genetic material. Defects in DNA damage signaling and repair result in genomic instability, a hallmark of cancer, and often cause lethality, underlining the importance of these processes in the cell and whole organism. The past decade has seen huge advances in our understanding of how the signal transduction pathways triggered by DNA damage radically alter cell behavior. In contrast, it is still unclear how primary DNA damage is detected and how this interfaces with signal transduction and DNA repair proteins.

The Wellcome Trust/Cancer Research UK Institute (of Cancer and Developmental Biology) and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. E-mail: spj13{at}mole.bio.cam.ac.uk; jwr24{at}mole.bio.cam.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)